Endometrial ossification

Ganem, Kenneth; Parsons, Langdon; Friedell, Gilbert H.

doi:10.1016/0002-9378(62)90175-8

Cited by 33 publications

(19 citation statements)

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“…Sporadic cases without antecedent pregnancy support this theory [9,10,11,12]. Over the past few decades there have been several case reports describing endometrial ossification [13,14,15,16,17]. It is most commonly believed to be due to retained fetal bone fragments, but some cases may be due to metaplasia of mature endometrial stromal cells in response to chronic inflammation or trauma [9].…”

Section: Etiopathologymentioning

confidence: 94%

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Hysteroscopic removal of intrauterine retained fetal bones

et al. 2004

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Fetus papyraceus is a well-recognized complication of missed abortion or intrauterine fetal death. However, prolonged intrauterine retention of parts of the fetal skeleton is not adequately reported in the literature. Prolonged retention of intrauterine bone is a recognized cause of secondary infertility. Literature regarding endometrial ossification contains more than 80 cases, with 80% occurring after pregnancy. Common symptoms include menorrhagia, menometrorraghia, pelvic pain and infertility. Several theories have been proposed to explain osseous tissue within the uterine cavity. The most widely accepted is that ossification represents retained fetal bones following spontaneous, missed, incomplete or therapeutic abortion, suggesting that the fetus achieved at least 12 weeks gestation in order for endochondral ossification to occur. In contemporary gynecology, transvaginal sonographic diagnosis of retained fetal bones is made and the bones removed with the help of a resectoscope. Hysteroscopy is invaluable in achieving a cure for these patients without resorting to more aggressive surgery. Gonadotropin-releasing hormone analogues (GnRHa) have many new uses in gynecology. Several clinical studies have demonstrated a mean decrease in uterine volume after about 3-6 months of therapy. These patients might be candidates for GnRHa therapy so that a smaller corpus with an atrophic endometrium might aid in hysteroscopic retrieval of the retained bony fragments.

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Section: Etiopathologymentioning

confidence: 94%

“…Six successful pregnancies were reported in this analyzed group of 19 patients following removal of retained fetal bones [7,8,10,13,14,15,16,17,21].…”

Section: Diagnosismentioning

confidence: 99%

Hysteroscopic removal of intrauterine retained fetal bones

et al. 2004

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“…When both structures were found together, there was always a pattern of endochondral ossification. Chronic endome tritis [Ganem et al 1962] or foreign body reaction [de Brux et al, 1956;Brocq et al, 1948] was reported by some investigators. A reaction of the surrounding tissue was not always found.…”

Section: Introductionmentioning

confidence: 99%

“…Erbslöh and Schweikart [1943] and Ganem et al [1962] reported endometrium, partially covered with clearly visible, long spicules of bone. On microscopical examination the bone and cartilage fragments were well differentiated and mostly avital.…”

Section: Introductionmentioning

confidence: 99%

Endometrial Ossification: Unilateral Manifestation in a Septate Uterus

Wetzels¹,

Essed²,

Haan³

et al. 1982

Gynecol Obstet Invest

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The occurrence of bone in endometrial stroma of a 31-year-old nulligravida who attended the outpatient clinic for infertility (Ziekenhuis Annadal, Department of Obstetrics and Gynaecology, State University Limburg, The Netherlands) is described. A review of the literature is given and the theories about the etiology are discussed. It seems apparent that in the described patient, only a locally acting cause can explain the findings.

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“…Über das seltene Vorkommen von Verknöcherungen des Endometriums wird bereits seit einem Jahrhundert immer wieder berichtet [1] [7] beschrieben.…”

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