Endometrial morphology and pituitary-gonadal axis dysfunction in women of reproductive age undergoing chronic haemodialysis--a multicentre study

Matuszkiewicz‐Rowińska, Joanna; Skórzewska, Katarzyna; Radowicki, Stanisław; Niemczyk, Stanisław; Sokalski, Antoni; Przedlacki, J; Puka, J; Świtalski, Marek; Wardyn, Kazimierz; Grochowski, Janusz; Ostrowski, K.

doi:10.1093/ndt/gfh279

Cited by 56 publications

(49 citation statements)

References 6 publications

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“…Additionally, lack of cyclic LH release leads to the absence of the LH surge necessary for ovulation [3]. Estradiol and progesterone are decreased in uremic women, which can result in uterine atrophy [4]. Reduced prolactin clearance by the kidneys also results in hyperprolactinemia, further inhibiting ovulation [5].…”

Section: Fertility and Esrdmentioning

confidence: 99%

Pregnancy and End-Stage Renal Disease

2018

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Pregnancy is uncommon in women with end-stage renal disease (ESRD). Fertility rates are low in women on dialysis, and physicians still frequently counsel women with ESRD against pregnancy. Advancements in the delivery of dialysis and obstetric care have led to improved live birth rates in women on dialysis, so pregnancy for young women with ESRD is now more feasible and safer. However, these pregnancies remain high-risk for both maternal and fetal complications, necessitating experienced multidisciplinary care. In this article, we review fertility issues in women with ESRD, discuss pregnancy outcomes in women on dialysis, and provide an approach for management of pregnant women with ESRD.

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Section: Fertility and Esrdmentioning

confidence: 99%

Pregnancy and End-Stage Renal Disease

2018

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“…There is an earlier onset of menopause in women with CKD on an average by 4.5 years as compared to general population [6, 7]. Among women on hemodialysis, 73% have menstrual disorders and amenorrhea present in half of them [8]. Women with end-stage renal disease (ESRD), especially with amenorrhea, have high serum prolactin due to impaired renal clearance, increased luteinizing hormone (LH) and follicular stimulating hormone (FSH), and reduced estradiol and progesterone concentration.…”

Section: Sexual Functionmentioning

confidence: 99%

Overview of Pregnancy in Renal Transplant Patients

Shah

Verma

2016

International Journal of Nephrology

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Kidney transplantation offers best hope to women with end-stage renal disease who wish to become pregnant. Pregnancy in a kidney transplant recipient continues to remain challenging due to side effects of immunosuppressive medication, risk of deterioration of allograft function, risk of adverse maternal complications of preeclampsia and hypertension, and risk of adverse fetal outcomes of premature birth, low birth weight, and small for gestational age infants. The factors associated with poor pregnancy outcomes include presence of hypertension, serum creatinine greater than 1.4 mg/dL, and proteinuria. The recommended maintenance immunosuppression in pregnant women is calcineurin inhibitors (tacrolimus/cyclosporine), azathioprine, and low dose prednisone; and it is considered safe. Sirolimus and mycophenolate mofetil should be stopped 6 weeks prior to conception. The optimal time to conception continues to remain an area of contention. It is important that counseling for childbearing should start as early as prior to getting a kidney transplant and should be done at every clinic visit after transplant. Breast-feeding is not contraindicated and should not be discouraged. This review will help the physicians in medical optimization and counseling of renal transplant recipients of childbearing age.

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“…Üreme çağındaki hemodiyaliz tedavisi alan kadınlarda biyopsi ile "patolojik endometrium morfolojisi"nin çok yaygın olduğu görülmüştür (%80) (19). Hemodiyaliz süresi ve/veya sıklığının uzatılması ile hastaların yaşam süresinde artış yanında yaşam kalitesi, fiziksel ve kognitif fonksiyonlarında iyileşmeler gözlendiği bilinmektedir (20)(21)(22).…”

Section: Turk Neph Dial Transpl 2017; 26 (1): 35-40unclassified

Frequency and Outcomes of Pregnancy on Nocturnal Home Haemodialysis

Demirci¹,

Demirci²,

Aşçı³

et al. 2017

Turk Neph Dial Transpl

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ÖzAMAÇ: Diyaliz tedavisi alan doğurgan çağdaki kadınlarda gebelik nadir gözlenmektedir ve kötü sonuçlar ile birliktedir. 1990'lı yıllarda yayınlanan çeşitli çalışmalarda gebelik oranları 0,3-0,5/100 hasta-yılı olarak saptanmış ve bu gebeliklerde canlı doğum oranları düşük kalmıştır. Daha yeni çalışmalar, intensif hemodiyalizin fertiliteyi ve canlı doğum oranını artırdığını göstermektedir.Amacımız evde haftada üç gün nokturnal hemodiyaliz (NHD) tedavisinin klinik ve biyokimyasal parametrelerdeki değişiklikler ile birlikte başarılı gebelik sonuçları ve canlı doğum oranlarına katkısının olup olmadığını değerlendirmektir. Üç gebe hasta 38, 35 ve 38. haftalarda herhangi bir maternal ve fetal komplikasyon olmadan sezeryanseksiyo ile üç sağlıklı bebek doğurdu. Doğum ağırlıkları sırayla 2.750, 2.550 ve 3.100 g. idi. Dördüncü hasta (sekonder amiloidoz ve multipl spontan abortus öyküsü olan) 25. haftada erken doğum yaptı ve bebek neonatal ikinci günde exitus oldu. GereÇ ve SONUÇ:Çalışmamızda üreme çağındaki kadınlarda evde nokturnal hemodiyaliz tedavisinin yüksek konsepsiyon ve canlı doğum oranları ile birlikte olduğunu gözlemledik. ANAhTAr SÖzCükLer: Ev hemodiyalizi, Gebelik, NokturnalABSTrACT OBJeCTIVe: Pregnancy in women of reproductive age on dialysis is rare and has a poor outcome. Several studies published in the 1990s revealed pregnancy rates of 0.3 to 0.5 per 100 patient-years, but not all pregnancies resulted in live births. More recent studies suggest that intensive haemodialysis increases fertility and successful pregnancies with live births.Our objectives were to evaluate whether nocturnal home haemodialysis (NHHD) three times a week supports successful pregnancies and live births in addition to the changes in clinical and biochemical parameters. mATerIAL and meThODS: Descriptive cohort study analysing pregnancies and their outcomes in 60 women of reproductive age (14-44 years) who

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Endometrial morphology and pituitary-gonadal axis dysfunction in women of reproductive age undergoing chronic haemodialysis--a multicentre study

Cited by 56 publications

References 6 publications

Pregnancy and End-Stage Renal Disease

Pregnancy and End-Stage Renal Disease

Overview of Pregnancy in Renal Transplant Patients

Frequency and Outcomes of Pregnancy on Nocturnal Home Haemodialysis

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