Endometrial microRNAs and their aberrant expression patterns

Tamaru, Shunsuke; Kajihara, Takeshi; Mizuno, Yosuke; Mizuno, Yumi; Tochigi, Hideno; Ishihara, O

doi:10.1007/s00795-020-00252-8

Cited by 12 publications

(7 citation statements)

References 90 publications

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“…It is well documented that miRNA expression in the human endometrium is dependent on the menstrual cycle phase and is regulated by sex steroids [ 106 ]. A broad range of different miRNAs involved in the pathogenesis of endometriosis and ectopic pregnancy has been described and they are summarized in Figure 3 [ 35 , 106 , 107 , 108 ]. In this part of the review, we focus on miRNAs that may constitute a link between these two diseases.…”

Section: The Role Of Micrornamentioning

confidence: 99%

Molecular Mechanisms Underlying the Association between Endometriosis and Ectopic Pregnancy

Załęcka

Pankiewicz²,

Issat³

et al. 2022

IJMS

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Endometriosis is a common inflammatory disease characterized by the presence of endometrial cells outside the uterine cavity. It is estimated that it affects 10% of women of reproductive age. Its pathogenesis covers a wide range of abnormalities, including adhesion, proliferation, and cell signaling disturbances. It is associated with a significant deterioration in quality of life as a result of chronic pelvic pain and may also lead to infertility. One of the most serious complications of endometriosis is an ectopic pregnancy (EP). Currently, the exact mechanism explaining this phenomenon is unknown; therefore, there are no effective methods of prevention. It is assumed that the pathogenesis of EP is influenced by abnormalities in the contraction of the fallopian tube muscles, the mobility of the cilia, and in the fallopian microenvironment. Endometriosis can disrupt function on all three levels and thus contribute to the implantation of the embryo beyond the physiological site. This review takes into account aspects of the molecular mechanisms involved in the pathophysiology of endometriosis and EP, with particular emphasis on the similarities between them.

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Section: The Role Of Micrornamentioning

confidence: 99%

Molecular Mechanisms Underlying the Association between Endometriosis and Ectopic Pregnancy

Załęcka

Pankiewicz²,

Issat³

et al. 2022

IJMS

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“…14; 52 miRNA genes, only paternal allelic expression) that are nearly exclusively expressed in the placenta. C19MC has evolved in the primate lineage and C14MC among eutherians ( Morales-Prieto et al, 2013 ; Tamaru et al, 2020 ). C14MC is one of the largest mammalian miRNA clusters and is located within an imprinted chromosomal region DLK1-DIO3, harboring also either paternally or maternally imprinted genes ( DLK1, RTL1, MEG3 , MEG8 and DIO3 ) and C/D small nucleolar RNAs (SNORDs) ( Seitz et al, 2004 ; Pilvar et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Coordinated Expressional Landscape of the Human Placental miRNome and Transcriptome

Inno

Kikas

Lillepea

et al. 2021

Front. Cell Dev. Biol.

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Placenta is a unique organ that serves its own function, and contributes to maternal gestational adaptation and fetal development. Coordination of its transcriptome to satisfy all the maternal-fetal needs across gestation is not fully understood. MicroRNAs are powerful transcriptome modulators capable to adjust rapidly the expression level and dynamics of large gene sets. This MiR-Seq based study presents a multi-omics investigation of the human placental miRNome and its synergy with the transcriptome. The analysis included 52 placentas representing three trimesters of normal pregnancy, and term cases of late-onset preeclampsia (LO-PE), gestational diabetes and affected fetal growth. Gestational-age dependent differential expression (FDR < 0.05) was detected for 319 of 417 tested miRNAs (76.5%). A shared list of target genes of dynamic miRNAs suggested their coordinated action. The most abundant miR-143-3p revealed as a marker for pregnancy progression. The data suggested critical, but distinct roles of placenta-specific imprinted C19MC and C14MC miRNA clusters. Paternally encoded primate-specific C19MC was highly transcribed during first trimester, potentially fine-tuning the early placental transcriptome in dosage-sensitive manner. Maternally encoded eutherian C14MC showed high expression until term, underlining its key contribution across gestation. A major shift in placental miRNome (16% miRNAs) was observed in LO-PE, but not in other term pregnancy complications. Notably, 13/38 upregulated miRNAs were transcribed from C19MC and only one from C14MC, whereas 11/28 downregulated miRNAs represented C14MC and none C19MC. miR-210-3p, miR-512-5p, miR-32-5p, miR-19a-3p, miR-590-3p, miR-379-5p were differentially expressed in LO-PE and cases of small-for-gestational-age newborns, supporting a shared etiology. Expression correlation analysis with the RNA-Seq data (16,567 genes) of the same samples clustered PE-linked miRNAs into five groups. Large notable clusters of miRNA–gene pairs showing directly and inversely correlated expression dynamics suggested potential functional relationships in both scenarios. The first genome-wide study of placental miR-eQTLs identified 66 placental SNVs associated with the expression of neighboring miRNAs, including PE-linked miRNAs miR-30a-5p, miR-210-3p, miR-490-3p and miR-518-5p. This study provided a rich catalog of miRNAs for further in-depth investigations of their individual and joint effect on placental transcriptome. Several highlighted miRNAs may serve as potential biomarkers for pregnancy monitoring and targets to prevent or treat gestational disorders.

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“…In the human endometrium, several studies, including next generation sequencing have identified the expression of several miRNAs. Among those altered include members of the miR-200 family (Alowayed et al, 2016;Tamaru et al, 2020).…”

Section: Sgk1 In the Regulation Of Endometrial Function And Infertilitymentioning

confidence: 99%

The Enigmatic Role of Serum & Glucocorticoid Inducible Kinase 1 in the Endometrium

Läng

Rajaxavier

Singh

et al. 2020

Front. Cell Dev. Biol.

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The serum-and glucocorticoid-inducible kinase 1 (SGK1) is subject to genetic up-regulation by diverse stimulators including glucocorticoids, mineralocorticoids, dehydration, ischemia, radiation and hyperosmotic shock. To become active, the expressed kinase requires phosphorylation, which is accomplished by PI3K/PDK1 and mTOR dependent signaling. SGK1 enhances the expression/activity of various transport proteins including Na + /K +-ATPase as well as ion-, glucose-, and amino acid-carriers in the plasma membrane. SGK1 can further up-regulate diverse ion channels, such as Na +-, Ca 2+-, K +-and Cl − channels. SGK1 regulates expression/activity of a wide variety of transcription factors (such as FKHRL1/Foxo3a, β-catenin, NFκB and p53). SGK1 thus contributes to the regulation of transport, glycolysis, angiogenesis, cell survival, immune regulation, cell migration, tissue fibrosis and tissue calcification. In this review we summarized the current findings that SGK1 plays a crucial function in the regulation of endometrial function. Specifically, it plays a dual role in the regulation of endometrial receptivity necessary for implantation and, subsequently in pregnancy maintenance. Furthermore, fetal programming of blood pressure regulation requires maternal SGK1. Underlying mechanisms are, however, still ill-defined and there is a substantial need for additional information to fully understand the role of SGK1 in the orchestration of embryo implantation, embryo survival and fetal programming.

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Endometrial microRNAs and their aberrant expression patterns

Cited by 12 publications

References 90 publications

Molecular Mechanisms Underlying the Association between Endometriosis and Ectopic Pregnancy

Molecular Mechanisms Underlying the Association between Endometriosis and Ectopic Pregnancy

Coordinated Expressional Landscape of the Human Placental miRNome and Transcriptome

The Enigmatic Role of Serum & Glucocorticoid Inducible Kinase 1 in the Endometrium

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