Endometrial microbiota from endometrial cancer and paired pericancer tissues in postmenopausal women: differences and clinical relevance

Bouteaud, Jeanne; Shaltout, Ola; Christakis, Marie K.; Murtaza, Fahmeeda; Wolfman, Wendy; Shirreff, Lindsay

doi:10.1097/gme.0000000000002053

Cited by 7 publications

(4 citation statements)

References 47 publications

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“…Carcinogenesis may be able to cause local microbiome variation. Wang et al (127) revealed that endometrial cancer tissues differed significantly from the non-cancerous fraction of the microbiome, accompanied by elevated α diversity and enrichment of Prevotella, Atopobium, Anaerococcus, Dialister, Porphyromonas and Peptoniphilus, similar to the dysbiotic state of the vaginal flora (127). The differences in results are related to the method of tissue sampling and the magnitude of contamination potential, the scientific nature of which needs to be confirmed by numerous studies.…”

Section: Gynecological Cancer Microbiomementioning

confidence: 99%

Vaginal and tumor microbiomes in gynecological cancer (Review)

et al. 2023

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Cervical, ovarian and endometrial cancer are the three most common types of gynecologic cancer. As a hub, the vagina connects the site of gynecological cancer with the external environment. Lactobacilli participate in the formation of a healthy vaginal microenvironment as the first line of defense against pathogen invasion; a dysbiotic vaginal microenvironment loses its original protective function and is associated with the onset, metastasis, poor efficacy and poor prognosis of gynecological cancer. The early diagnosis of cancer is the key to improve the survival time of patients with cancer. The screening of Porphyromonas, Sneathia and Atopobium vaginae, and other microbial markers, can assist the diagnosis of gynecological cancer, and screen out the high-risk population as early as possible. With the in-depth study of the microbes in tumor tissues, reasearchers have analyzed the immunological associations of microorganisms in tumor tissues. Due to the structural-functional interconnection between the organ of gynecological tumorigenesis and the vagina, the present study aims to review the relationship between vaginal and tumor microorganisms and gynecological cancer in terms of occurrence, screening, treatment and prognosis. Contents 1. Introduction 2. Vaginal microbes and the acidic vaginal environment 3. Vaginal microbes in gynecological malignancies 4. Tumor microbiome in gynecological malignancies 5. Prospects

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Section: Gynecological Cancer Microbiomementioning

confidence: 99%

Vaginal and tumor microbiomes in gynecological cancer (Review)

et al. 2023

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“…The presence of Porphyromas somerae is the most predictive microbial marker of endometrial cancer and might be useful in detecting endometrial cancer in high-risk, asymptomatic women. Wang et al [ 38 ] revealed the significant differences between the paired endometrial cancer and adjacent non-endometrial cancer endometrial microbiota in their clinical study of 28 menopausal women who were histopathologically diagnosed with endometrioid adenocarcinoma, some of whom underwent hysterectomy using the open surgical approach.…”

Section: Changes In Vaginal Microbiota In Menopausal Womenmentioning

confidence: 99%

Menopausal Changes in the Microbiome—A Review Focused on the Genitourinary Microbiome

Park

Cho

2023

Diagnostics

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A balanced interaction between the host and its microbiome is crucial to health. Research regarding the significance of the gut and vaginal microbiomes in female health is substantial. However, less data regarding the urinary microbiome are available. Interactions between the gut, vaginal, and urinary microbiomes are also currently being researched. Hormone-induced dysbiosis after menopause is believed to have effects on physical changes and health consequences. Postmenopausal changes in the gut microbiome are associated with increased short-chain fatty acids and hydrogen sulfide levels. Increased vaginal pH caused by reduced estrogen alters the vaginal microbiome, resulting in reduced levels of Lactobacillus. Such changes influence the vaginal structure and functions, contributing to the onset of genitourinary syndrome of menopause. A dysbiosis of the urinary microbiome is associated with urgency and urinary incontinence and also related to interstitial cystitis/bladder pain syndrome and neuropathic bladder. As these diseases commonly affect postmenopausal women, hormone-induced changes in the microbiome may play a role. Menopause increases the alpha diversity of the urinary microbiome and lowers the percentage of Lactobacillus in urine, and such changes precede recurrent cystitis. More research regarding the effects of changes in the urinary microbiome due to menopause on urinary tract diseases is needed.

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“…An alteration in the estrobolome (dysbiosis) and its regulatory functions leads to an imbalance of various biological processes, promoting the onset of pathologies such as cancer. Wang et al [89] observed a different microbiota in endometrial cancer (EC) tissues as compared to pericancer tissues. In particular, EC tissues were enriched in the genera Prevotella, Atopobium, Peptostreptococcus, Anaerococcus, Fastidiosipila, Finegoldia, DNF00809, Dialister, Peptoniphilus, Porphyromonas, Anaeroglobus, and Criibacterium, while an abundance of Lactobacillus is found in PC tissues [89].…”

Section: Microbiota and Endometrial Cancermentioning

confidence: 99%

“…Wang et al [89] observed a different microbiota in endometrial cancer (EC) tissues as compared to pericancer tissues. In particular, EC tissues were enriched in the genera Prevotella, Atopobium, Peptostreptococcus, Anaerococcus, Fastidiosipila, Finegoldia, DNF00809, Dialister, Peptoniphilus, Porphyromonas, Anaeroglobus, and Criibacterium, while an abundance of Lactobacillus is found in PC tissues [89]. Furthermore, a high abundance of Prevotella and high levels of D-dimer were observed in EC tissues, often correlating with disease severity and poor prognosis [90].…”

Section: Microbiota and Endometrial Cancermentioning

confidence: 99%

Gynecological Cancers and Microbiota Dynamics: Insights into Pathogenesis and Therapy

Cocomazzi,

Del Pup,

Contu

et al. 2024

IJMS

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In recent years, the relationship between the microbiota and various aspects of health has become a focal point of scientific investigation. Although the most studied microbiota concern the gastrointestinal tract, recently, the interest has also been extended to other body districts. Female genital tract dysbiosis and its possible impact on pathologies such as endometriosis, polycystic ovary syndrome (PCOS), pelvic inflammatory disease (PID), and gynecological cancers have been unveiled. The incursion of pathogenic microbes alters the ecological equilibrium of the vagina, triggering inflammation and compromising immune defense, potentially fostering an environment conducive to cancer development. The most common types of gynecological cancer include cervical, endometrial, and ovarian cancer, which occur in women of any age but especially in postmenopausal women. Several studies highlighted that a low presence of lactobacilli at the vaginal level, and consequently, in related areas (such as the endometrium and ovary), correlates with a higher risk of gynecological pathology and likely contributes to increased incidence and worse prognosis of gynecological cancers. The complex interplay between microbial communities and the development, progression, and treatment of gynecologic malignancies is a burgeoning field not yet fully understood. The intricate crosstalk between the gut microbiota and systemic inflammation introduces a new dimension to our understanding of gynecologic cancers. The objective of this review is to focus attention on the association between vaginal microbiota and gynecological malignancies and provide detailed knowledge for future diagnostic and therapeutic strategies.

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Endometrial microbiota from endometrial cancer and paired pericancer tissues in postmenopausal women: differences and clinical relevance

Cited by 7 publications

References 47 publications

Vaginal and tumor microbiomes in gynecological cancer (Review)

Vaginal and tumor microbiomes in gynecological cancer (Review)

Menopausal Changes in the Microbiome—A Review Focused on the Genitourinary Microbiome

Gynecological Cancers and Microbiota Dynamics: Insights into Pathogenesis and Therapy

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