Endometrial lymphoid tissue in the timed endometrial biopsy: Morphometric and immunohistochemical aspects

Klentzeris, Lucas D.; Bulmer, Judith N.; Warren, Alistair; Morrison, Lynn; Li, Tin-Chin; Cooke, I. D.

doi:10.1016/s0002-9378(11)91568-3

Cited by 90 publications

(44 citation statements)

References 18 publications

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“…Macrophages (CD14-or CD68-positive cells) are present in the non-pregnant endometrium; some studies have not detected any alteration in numbers throughout the menstrual cycle (Rieger et al, 2004) but others have noted increased macrophage numbers in the secretory phase, using both CD14 (Bulmer et al, 1991) and CD68 (Klentzeris et al, 1992). In contrast with uNK cells, macrophage numbers do not alter substantially with increasing gestational age, although the proportion of endometrial leukocytes accounted for by macrophages increases as the number of uNK cells is reduced in the second half of pregnancy.…”

Section: Distribution Of Macrophagesmentioning

confidence: 99%

“…Klentzeris et al (1992) noted an increase in numbers of CD8+ T cells in timed endometrial biopsies between 4 and 7 days after the luteinising hormone surge but others have not noted any difference between proliferative and secretory phases of the cycle (Bulmer et al, 1991). Since numbers of T lymphocytes vary little if any during the menstrual cycle and pregnancy it has been suggested that these cells do not have a key role in the establishment and maintenance of pregnancy (Vassiliadou and Bulmer, 1996), and their role is simply to provide immune protection against external antigens.…”

Section: Distribution Of T Lymphocytesmentioning

confidence: 99%

“…Since numbers of T lymphocytes vary little if any during the menstrual cycle and pregnancy it has been suggested that these cells do not have a key role in the establishment and maintenance of pregnancy (Vassiliadou and Bulmer, 1996), and their role is simply to provide immune protection against external antigens. However, the finding that there is a reversal in the CD8:CD4 T lymphocyte ratio in endometrium, compared with peripheral blood does suggest a specific role for decidual T lymphocytes in pregnancy maintenance (Bulmer et al, 1991;Klentzeris et al, 1992). There is also considerable interest in the balance between Th1 and Th2 type cytokines in pregnancy.…”

Section: Distribution Of T Lymphocytesmentioning

confidence: 99%

“…The large increase in endometrial leukocyte numbers in the mid secretory phase of the menstrual cycle at the expected time of implantation in a fertilized cycle and in early pregnancy (Bulmer et al, 1991;Klentzeris et al, 1992) is one of the major observations implicating endometrial leukocytes as playing a key role in establishment of the fetal-placental unit and the subsequent immunological maintenance of pregnancy. Whether this increase in leukocyte numbers is due to recruitment from other sites or to in situ proliferation in response to direct/indirect hormonal influences and/or locally produced soluble factors is not known.…”

Section: Introductionmentioning

confidence: 99%

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Immune cells in the placental bed

Bulmer¹,

Williams²,

Lash³

2010

Int. J. Dev. Biol.

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313

280

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Section: Distribution Of Macrophagesmentioning

confidence: 99%

Section: Distribution Of T Lymphocytesmentioning

confidence: 99%

Section: Distribution Of T Lymphocytesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Immune cells in the placental bed

Bulmer¹,

Williams²,

Lash³

2010

Int. J. Dev. Biol.

Self Cite

313

280

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“…In normal pregnancy, w30-40% of decidual stromal cells are leucocytes (Bulmer et al 1991); in the first trimester, uterine natural killer (uNK) cells account for up to 70%, macrophages up to 30% (Bulmer et al 1988) and T-lymphocytes fewer than 20% (Bulmer et al 1991) of the total leucocyte population (Bulmer et al 1991, King & Loke 1991, Klentzeris et al 1992. In contrast to first trimester decidua, third trimester decidua has been the subject of less research.…”

Section: Introductionmentioning

confidence: 99%

Altered decidual leucocyte populations in the placental bed in pre-eclampsia and foetal growth restriction: a comparison with late normal pregnancy

Williams¹,

Bulmer²,

Searle³

et al. 2009

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113

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Alterations in the balance of leucocyte populations in uterine decidua may lead to the generation of an unfavourable cytokine environment that is associated with unsuccessful pregnancy. Single and double immunohistochemical labelling was used to examine leucocyte populations in decidua from normal third trimester, foetal growth-restricted and pre-eclamptic pregnancies. Placental bed biopsies from 12 women undergoing elective Caesarean section with no hypertension or foetal growth restriction (FGR), 8 women with FGR without maternal hypertension and 12 women with pre-eclampsia (PE) were used to quantify decidual CD56C uterine NK cells, CD14C macrophages, CD3CT-lymphocytes and CD8C lymphocytes. CD3CCD56C, CD8CCD56C and CD161CCD3C double-labelled cells in decidua were compared in PE and control decidua. Decidual CD3CT-lymphocytes (P!0.01), CD8C cytotoxic T-lymphocytes (P!0.05), CD14C macrophages (P!0.0001) and CD56C uterine natural killer (uNK) cells (PZ0.01) were decreased in placental bed biopsies from women with PE compared with control third trimester decidua. By contrast, only CD56C uNK cells were decreased in FGR decidua (P!0.05). Double-positive CD8CCD56C cells were also decreased in PE compared with control third trimester decidua (P!0.05). The reduction in specific leucocyte subset numbers in PE and uNK cells in FGR suggests that altered local cytokine balance may be important in defective trophoblast invasion and spiral artery transformation in these pathological pregnancies.

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Regulated expression of cadherin-6 and cadherin-11 in the glandular epithelial and stromal cells of the human endometrium

et al. 1998

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The cadherins are key morphoregulators. A switch in the cadherin subtype(s) expressed by a population of cells has been associated with the differentiation and formation of tissues during embryonic development. To date, the role(s) of the cadherins in the highly regulated remodeling processes which occur in the human endometrium in preparation for the implanting embryo remain poorly characterized. Here we report that two atypical cadherins, known as cadherin‐6 and cadherin‐11, are spatiotemporally expressed in the human endometrium during the menstrual cycle. Cadherin‐6 levels are high in both the glandular epithelium and stroma of the endometrium during the follicular phase and decline as the cycle enters the luteal phase. The down‐regulation of cadherin‐6 in the glandular epithelium during the luteal phase does not effect the levels of cadherin‐11 in this cell type. In contrast, the loss of cadherin‐6 expression in endometrial stroma cells is concomitant with an increase in the levels of cadherin‐11. Collectively, these observations suggest that multiple factors regulate the expression of these two endometrial cadherins. As a first step in identifying these factors, we examined the effects of progesterone on cadherin‐6 and cadherin‐11 expression in isolated endometrial stromal cells. Progesterone was capable of differentially regulating the expression of these two stromal cell adhesion molecules. These findings lend further support to our hypothesis that steroids are key regulators of cadherin expression in mammalian tissues. Dev. Dyn. 1998;211:238‐247. © 1998 Wiley‐Liss, Inc.

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Endometrial lymphoid tissue in the timed endometrial biopsy: Morphometric and immunohistochemical aspects

Cited by 90 publications

References 18 publications

Immune cells in the placental bed

Immune cells in the placental bed

Altered decidual leucocyte populations in the placental bed in pre-eclampsia and foetal growth restriction: a comparison with late normal pregnancy

Regulated expression of cadherin-6 and cadherin-11 in the glandular epithelial and stromal cells of the human endometrium

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