Endometrial leukocyte subpopulations in women with endometriosis

Klentzeris, Lucas D.; Bulmer, Judith N.; Liu, D.T.; Morrison, Lynn

doi:10.1016/0301-2115(95)02222-s

Cited by 44 publications

(31 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, other studies have reported no difference between the patients suffering from recurrent pregnancy loss and fertile patients Likewise, the data from studies examining uNK cells in patients with endometriosis are also variable. Some laboratories have reported a lower percentage of CD56 + NK cells and a defect in NK activity in the eutopic endometrium of women with endometriosis . Studies from our laboratory did not observe a difference in the percentage of CD56+ uNK cells when comparing patients with endometriosis to healthy controls.…”

Section: Differences In Uterine Nk Cells Associated With Implantationcontrasting

confidence: 49%

Uterine Leukocyte Function and Dysfunction: A Hypothesis on the Impact of Endometriosis

Parkin

Fazleabas

2016

American J Rep Immunol

View full text Add to dashboard Cite

Endometriosis is a chronic inflammatory disease characterized by the growth of endometrial glands and stroma outside of the uterus. The disease affects approximately 10–15% of women of reproductive age and presents with clinical symptoms of pelvic pain and infertility. Changes in the leukocyte populations within the ectopic tissue and eutopic endometrium have been reported, and data suggest these alterations contribute to the pathology and symptoms of the disease. In this review, we discussed differences when comparing uterine NK cells and regulatory T cells within the eutopic endometrium between patients with endometriosis and healthy patients, and how these differences relate to implantation failure and/or decreased clearance of menstrual tissue in patients with the disease. The data demonstrate a critical need to examine endometrium and menstrual tissue in patients with endometriosis excluded from studies examining unknown causes of infertility and heavy menstrual bleeding. The information gathered from excluded patients will further enhance our understanding of how the immune system contributes to the pathophysiology of endometriosis and help to identify biomarkers for patients at higher risk for developing endometriosis‐associated infertility.

show abstract

Section: Differences In Uterine Nk Cells Associated With Implantationcontrasting

confidence: 49%

Uterine Leukocyte Function and Dysfunction: A Hypothesis on the Impact of Endometriosis

Parkin

Fazleabas

2016

American J Rep Immunol

View full text Add to dashboard Cite

show abstract

“…Although not statistically different, a trend was observed for fewer T-suppressor/cytotoxic (CD8 + ) cells and endometrial granulated lymphocytes but more Thelper/inducer (CD4 + ) cells, CD68 + cells, and CD16 + cells in the endometrium of women with endometriosis. 21 Additional studies of specific endometrial cell types found no difference in defined stromal leukocyte subpopulations 22 yet increased numbers of CD45 + , CD43 + , and CD3 + intraepithelial leukocytes 23 when comparing eutopic endometrium from women with endometriosis with that of controls. While providing semiquantitative information about the leukocyte populations in these tissues, these studies have not provided data about the functional differences of endometrial leukocytes between the two groups.…”

Section: Immune Componentsmentioning

confidence: 96%

“…Wingfield et al 8 Kruitwagen et al 10 Isaacson et al 18 Bartosik et al 17 Odukoya et al 19 Helvacioglu et al 20 Klentzeris et al 21 Jones et al 22 Bulmer et al 23 Oosterlynck et al 26 Ota et al 27 & Nip et al 28…”

Section: Anomalymentioning

confidence: 99%

Endometrial Anomalies in Women with Endometriosis

Sharpe-Timms

2001

Annals of the New York Academy of Sciences

173

View full text Add to dashboard Cite

Endometriotic lesions are defined by extrauterine growth of endometrial glands and stroma. Retrograde menstruation with subsequent attachment, invasion, and neovascularization are believed to give rise to the endometriotic lesions. As most women exhibit some degree of retrograde menstruation, some other unidentified factor(s) must render certain women susceptible to attachment and growth of ectopic endometrial tissue. A variety of theories have been proposed to account for this susceptibility, including genetic predisposition, aberrant immunological response, and an altered peritoneal environment. Ectopic endometriotic lesions are histologically similar to their putative eutopic precursors, yet significant biochemical differences exist between these two tissues. Less information is available regarding differences between eutopic endometrium from women with or without endometriosis. This report describes anomalies in structure, proliferation, immune components, adhesion molecules, proteolytic enzymes and inhibitors, steroid and cytokine production and responsiveness, and gene expression and protein production that have been identified in eutopic endometrium from women with endometriosis.

show abstract

“…Similarly, evidence exists for both an association and lack of association between uNK cell number/function and infertility 15,16,17,18 . Only few studies have examined changes of uNK cell numbers in endometriosis, demonstrating a lower percentage of CD56 + NK cells and a defect in NK activity in the eutopic endometrium of women with endometriosis 19, 20, 21, 22 . However these studies did not focus on endometriosis patients with concomitant infertility disorders.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Uterine NK Cells in Women with Infertility or Recurrent Pregnancy Loss and Associated Endometriosis

Giuliani

Parkin

Lessey

et al. 2014

American J Rep Immunol

139

106

View full text Add to dashboard Cite

Problem Uterine natural killer cells (uNK) have been thought to play a key role in endometriosis and infertility. We investigated the expression of CD56, CD16 and NKp46 in endometrial tissues from 61 women with unexplained recurrent pregnancy loss (uRPL) or infertility (UI), and correlated this with the presence or absence of endometriosis. The results from the patients with sub-fertility were compared to those from 10 fertile patients. Method of study Mid-secretory phase endometrial biopsies were obtained and the endometrial expression of CD56, CD16 or NKp46 was identified by immunohistochemistry and quantified (ImageJ Software). Results The percentage of CD16+ cells was higher in women with uRPL (7.9±3.2) and UI (9.0±5.5), even when these conditions were associated with endometriosis (8.9±5.3), compared to fertile patients (5.6±2.4, p<0.05). Likewise, the ratio of NKp46+:CD56+ cells was higher in women with uRPL (0.28±0.25) and UI (0.21±0.2), even when these conditions were associated with endometriosis (0.19±0.14), compared to fertile patients (0.1±0.1, p<0.05). No differences were observed when comparing CD56. Conclusions Women, with or without endometriosis, who have larger populations of cytotoxic CD16+ uNK cells and/or higher populations of NKp46+CD56+ cells may be at greater risk for infertility disorders resulting from an inflammtory environment occuring during implantation or later during decidualization.

show abstract

Endometrial leukocyte subpopulations in women with endometriosis

Cited by 44 publications

References 34 publications

Uterine Leukocyte Function and Dysfunction: A Hypothesis on the Impact of Endometriosis

Uterine Leukocyte Function and Dysfunction: A Hypothesis on the Impact of Endometriosis

Endometrial Anomalies in Women with Endometriosis

Characterization of Uterine NK Cells in Women with Infertility or Recurrent Pregnancy Loss and Associated Endometriosis

Contact Info

Product

Resources

About