Endometrial injury in women undergoing in vitro fertilisation (IVF)

Lensen, Sarah; Armstrong, Sarah; Gibreel, Ahmed; Nastri, C.O.; Raine‐Fenning, Nick; Martins, W.P.

doi:10.1002/14651858.cd009517.pub4

Cited by 27 publications

(30 citation statements)

References 88 publications

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“…A recent meta-analysis suggested that the effect of endometrial biopsy/injury on live birth and clinical pregnancy among women undergoing IVF is unclear (Lensen et al, 2021). Notably, our study indicated that the clinical pregnancy and live birth rates of participants in the CE non-re-examination group were similar to those in the CE-negative and improved-CE groups, which suggests that antibiotic therapy is highly effective.…”

Section: Discussionsupporting

confidence: 46%

New biopsy after antibiotic treatment: effect on outcomes of assisted reproduction in patients with infertility and chronic endometritis

Liu

JuHuang²,

Li³

et al. 2022

Reproductive BioMedicine Online

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Section: Discussionsupporting

confidence: 46%

New biopsy after antibiotic treatment: effect on outcomes of assisted reproduction in patients with infertility and chronic endometritis

Liu

JuHuang²,

Li³

et al. 2022

Reproductive BioMedicine Online

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“…Bashiri et al 10 , who reviewed on recurrent implantation failure (RIF), suggested a new initial step in approach to patients with RIF, as in this study. A 2022 Cochrane review 11 calls for more trials, suggesting that there is only moderate-quality evidence that endometrial injury done between day 7 of the previous cycle and day 7 of the embryo transfer cycle can lead to increased clinical pregnancy and live birth rates in women with previous embryo transfer 12,13 . Our results of clinical characteristics in endometrial biopsy between the groups less than 90 days and the time between 90 and 180 days did not show differences between the groups with the characteristics of mother's age, BMI, type of endometrial preparation, natural cycle, and progesterone supplementation.…”

Section: Discussionmentioning

confidence: 99%

“…Embryo implantation, which is an important requirement for a successful pregnancy, can only occur in a receptive uterus. In humans, the uterus becomes favorable to embryo implantation between days 19 and 23 of the menstrual cycle, a period known as the implantation window 2 . At present, implantation is the critical step that limits the success of in vitro fertilization (IVF) techniques 3 .…”

Section: Introductionmentioning

confidence: 99%

Is the length of time between endometrial scratching and embryo transfer important for pregnancy success? An observational study

Ueno

Salgado

Ejzenberg

et al. 2023

Rev. Assoc. Med. Bras.

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OBJECTIVE: This study sought to evaluate the influence of time (early <90 days and late >90 days) and endometrial injury on pregnancy success. METHODS: This is a retrospective study in which all infertile women who underwent at least one in vitro fertilization cycle at Clinica Gera between 2010 and 2015 were considered for inclusion. We included patients with a normal ovarian reserve and regular menses at intervals of up to 30 days. A total of 315 patient files were reviewed, and the study group was composed of patients who faced fertility issues and had male-caused infertility or idiopathic infertility. Also, women with male or unknown cause of infertility who have performed endometrial biopsy and have undergone embryo transfer up to 180 days after this procedure between 2010 and 2015 were included. The patients were divided into two groups according to the interval between biopsy and embryo transfer: group 1 (early-an interval of <90 days) and group 2 (late-an interval of >90 days and up to 180 days). RESULTS: The results were superior for the group with an interval of less than 90 days relative to the group with an interval of more than 90 days (p<0.04). The pregnancy rates for group 1 and group 2 were 58.5% and 43.4%, respectively. The odds ratio for pregnancy success was 1.63 (95% confidence interval: 1.04 to 2.55). CONCLUSION: The early transfer of embryos (<90 days) may produce better results with a high rate of pregnancy. Further studies are necessary to identify the mechanism involved in this phenomenon.

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“…A recent, lengthy (125 pages) Cochrane review 56 included only 37 studies. No GRADE evaluation for the quality of evidence was performed.…”

Section: Discussionmentioning

confidence: 99%

Endometrial scratch injury in infertile women undergoingin vitrofertilization cycles: a systematic review and meta-analysis

et al. 2023

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Objective This study aimed to evaluate the effect of endometrial scratch injury (ESI) in infertile women undergoing in vitro fertilization (IVF). Methods We screened MEDLINE, CENTRAL, EMBASE, Web of Science, and the Cochrane Central Register from inception to April 2023 using keywords related to endometrial scratch, implantation, infertility, and IVF. We included 41 randomized, controlled trials of ESI in IVF cycles (9084 women). The primary outcomes were the clinical pregnancy, ongoing pregnancy, and live birth rates. Results The clinical pregnancy rate was reported in all 41 studies. The odds ratio (OR) for the clinical pregnancy rate had an effect estimate of 1.34 with a 95% confidence interval (CI) of 1.14 to 1.58. The live birth rate was reported in 32 studies with 8129 participants. The OR for the live birth rate had an effect estimate of 1.30 with a 95% CI of 1.06 to 1.60. The multiple pregnancy rate was reported in 21 studies with 5736 participants. The OR for the multiple pregnancy rate had an effect estimate of 1.35 with a 95% CI of 1.07 to 1.71. Conclusion ESI increases the clinical pregnancy, ongoing pregnancy, live birth, multiple pregnancy, and implantation rates in women undergoing IVF cycles.

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Endometrial injury in women undergoing in vitro fertilisation (IVF)

Cited by 27 publications

References 88 publications

New biopsy after antibiotic treatment: effect on outcomes of assisted reproduction in patients with infertility and chronic endometritis

New biopsy after antibiotic treatment: effect on outcomes of assisted reproduction in patients with infertility and chronic endometritis

Is the length of time between endometrial scratching and embryo transfer important for pregnancy success? An observational study

Endometrial scratch injury in infertile women undergoingin vitrofertilization cycles: a systematic review and meta-analysis

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