Endometrial Immune-Inflammatory Gene Signatures in Endometriosis

T helper 17 axis and endometrial macrophage disruption in menstrual effluent provides potential insights into the pathogenesis of endometriosis

“…On the basis of global immune transcriptomic profiles of endometriotic lesions, eutopic endometrium of patients, and endometrium from healthy, fertile controls, endometriotic lesions have unique immune gene signatures, specifically in the expression of genes for adhesion, inflammation, and implantation (7,(14)(15)(16). Keeping this in view, we hypothesized that the ME of patients with endometriosis will reveal distinct Tcell subsets and cytokine profiles.…”