Endometrial expression of anti-Müllerian hormone and its type II receptor in women with polycystic ovary syndrome

Paulson, Mariana; Sahlin, Lena; Hirschberg, Angelica Lindén

doi:10.1016/j.rbmo.2020.01.032

Cited by 5 publications

(3 citation statements)

References 31 publications

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“…To date, only one type II receptor named AMHR2 has been found for AMH in humans [31]. AMHR2 is present in several organs, including the prostate, lungs, brains, and the endometrium, suggesting that the biological effects of AMH may be much broader than initially thought [32][33][34]. AMHR2 is upregulated in the endometrium of women with endometriosis when compared to women without the disease [35].…”

Section: Discussionmentioning

confidence: 99%

High anti-Müllerian hormone (AMH) is associated with increased risks of ectopic pregnancy in women undergoing fresh embryo transfer cycle, a cohort study

Hunt

et al. 2023

Reprod Biol Endocrinol

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Background Ectopic pregnancy is more common amongst assisted reproduction cycles and is a cause of significant maternal morbidity. Few predictive markers exist to help identify and modify risk of ectopic pregnancy in preparing for embryo transfer. The relationship between serum and AMH and ectopic pregnancy rate is unknown. Methods This was a retrospective cohort study investigating women who underwent fresh embryo transfer cycles from January 2017 to December 2019 in Peking University Third Hospital. The primary outcome was ectopic pregnancy. Restricted cubic splines with four knots for AMH concentration (0-3, 3-6, 6-12, 12-max) were used to map out the non-linear relationship between the predicted ectopic pregnancy rate and the serum AMH concentration. Log binomial regression was used to test the crude risk ratio (cRR) and the adjusted risk ratio (aRR) after adjustment for confounders with 95% confidence intervals (CI) to determine the difference across various groups. Results A total of 13,718 cycles in women undergoing fresh embryo transfer were eligible for analysis. The ectopic pregnancy rate was 1.3% per embryo transfer cycle initiated and 3.3% per pregnancy. Serum AMH concentrations were higher amongst women with ectopic pregnancy than in women with a confirmed intrauterine pregnancy or heterotopic pregnancy or who did not become pregnant (Mean levels: 4.0 ng/ml vs 3.2 ng/ml, 1.7 ng/ml, and 2.8 ng/ml). An AMH concentration of 7 ng/ml represented the best cut-off value to predict ectopic pregnancy. The ectopic pregnancy rate was 3.4% per cycle and 7.5% per pregnancy in women with AMH levels ≥ 7 ng/ml; and 1.2% per cycle and 2.9% per pregnancy in women with AMH levels < 7 ng/ml. Serum AMH concentration ≥ 7 ng/ml was associated with an increased risk of ectopic pregnancy in all fresh embryo transfer cycles started (aRR = 2.35 (1.45, 3.58)) as well in women who became pregnant (aRR = 2.23 (1.49, 3.33). Conclusions Baseline AMH concentration ≥ 7 ng/ml is associated with an increased risk of ectopic pregnancy in fresh embryo transfer cycles.

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Section: Discussionmentioning

confidence: 99%

High anti-Müllerian hormone (AMH) is associated with increased risks of ectopic pregnancy in women undergoing fresh embryo transfer cycle, a cohort study

Hunt

et al. 2023

Reprod Biol Endocrinol

View full text Add to dashboard Cite

show abstract

“…[ 8 ] Moreover, the AMH signalling pathway was found intact during both proliferative and secretory phases of the menstrual cycle. [ 9 26 ] Signorile et al . proposed that the high AMH concentration could affect endometrial homeostasis through pro-apoptotic effects when using the endometriosis model.…”

Section: Discussionmentioning

confidence: 99%

“…[ 7 ] Several studies have reported that AMH and its receptor AMHRII are expressed in the endometrial stromal and epithelial cells. [ 8 9 10 ] Increased AMH concentrations in cultured endometrial tissue have been shown to decrease cell viability and promote apoptosis. [ 10 ] Similar findings were also reported in cultured endometriosis tissue.…”

Section: Introductionmentioning

confidence: 99%

The impact of high circulating anti-müllerian hormone on endometrial thickness and outcome of assisted reproductive technology in women with polycystic ovarian syndrome: A cohort study

et al. 2022

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The impact of anti-Müllerian hormone on endometrial thickness in gonadotropin stimulation/intrauterine insemination cycles: is there an effect on pregnancy outcomes?

Vagios

Sacha

James

et al. 2023

J Assist Reprod Genet

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Endometrial expression of anti-Müllerian hormone and its type II receptor in women with polycystic ovary syndrome

Cited by 5 publications

References 31 publications

High anti-Müllerian hormone (AMH) is associated with increased risks of ectopic pregnancy in women undergoing fresh embryo transfer cycle, a cohort study

High anti-Müllerian hormone (AMH) is associated with increased risks of ectopic pregnancy in women undergoing fresh embryo transfer cycle, a cohort study

The impact of high circulating anti-müllerian hormone on endometrial thickness and outcome of assisted reproductive technology in women with polycystic ovarian syndrome: A cohort study

The impact of anti-Müllerian hormone on endometrial thickness in gonadotropin stimulation/intrauterine insemination cycles: is there an effect on pregnancy outcomes?

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