Endometrial echo complex thickness in postmenopausal endometrial cancer

Chandavarkar, Uma; Kuperman, Julie; Muderspach, Laila I.; Opper, Neisha; Felix, Juan C.; Roman, Lynda D.

doi:10.1016/j.ygyno.2013.07.109

Cited by 14 publications

(13 citation statements)

References 17 publications

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“…Interestingly, they also reported that 37% of women with type I endometrial cancer had a thin EMS. 16 These findings are comparable to our results in which 28% had an EMS of 5 mm or less. If we apply the more stringent e4-mm EMS criterion to our data, our results are still comparable, with 25.8% of type II patients with a thin/indistinct EMS.…”

Section: Discussionsupporting

confidence: 91%

“…It is interesting to note that in this report 11% of type I endometrial cancers and 7% of type II endometrial cancers, approximately10% for all cancers, had an EMS less than 4 mm. 18 However, it has been well established that type II or high-grade endometrial cancers often arise without hyperplasia and account for 15% to 35% of endometrial cancer 16 had similar results, with 34% of all women with type II EC having an endometrial echogenic complex of 4 mm or less. Interestingly, they also reported that 37% of women with type I endometrial cancer had a thin EMS.…”

Section: Discussionmentioning

confidence: 99%

“…These studies support our findings that a thin or indistinct EMS does not reliably exclude type II endometrial cancer. 2,16,18 Women with type II endometrial cancers may not have classic risk factors such as obesity and may not be identified to have a thickened EMS on ultrasound, which may reduce suspicion for malignancy or further evaluation with histologic sampling. Therefore, counseling women with postmenopausal bleeding that a thin EMS has a false-negative rate ranging from 1% to 34%, which may be associated with a delay in diagnosis, should be performed if TVUS is used alone.…”

Section: Discussionmentioning

confidence: 99%

“…14,15 Furthermore, recent studies have shown that the 5-mm rule may miss up to 35% of patients with type II endometrial cancers. 16 Therefore, the purpose of this study was to examine the validity of the 5-mm rule when applied exclusively to women with type II endometrial cancer, as well as to correlate any additional ultrasound characteristics with type II endometrial cancer.…”

mentioning

confidence: 99%

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The Use of Transvaginal Ultrasound in Type II Endometrial Cancer

Billingsley

Kenne

Cansino

et al. 2015

International Journal of Gynecological Cancer

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Women with type II endometrial cancer had a thin/indistinct EMS on TVUS in approximately 25% of cases. Lack of any ultrasound abnormality, including a thickened EMS, was noted in approximately 10% of patients. The use of TVUS, which has been of value in type I cancer, is limited in type II endometrial cancer. Therefore, endometrial sampling should be included in the evaluation of all women with postmenopausal bleeding, regardless of EMS thickness.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

The Use of Transvaginal Ultrasound in Type II Endometrial Cancer

Billingsley

Kenne

Cansino

et al. 2015

International Journal of Gynecological Cancer

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“…Endometrial cancer is currently the most common malignancy of the female genital tract in Europe, USA, and Hong Kong. Around 90% of women eventually diagnosed with endometrial cancer initially presented with postmenopausal bleeding (PMB) . The aim in the evaluation of PMB is to exclude underlying malignancy .…”

Section: Introductionmentioning

confidence: 99%

Reappraisal of endometrial thickness for the detection of endometrial cancer in postmenopausal bleeding: a retrospective cohort study

Wong

Lao

Cheung

et al. 2015

BJOG

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Objective To estimate the accuracy of transvaginal ultrasound (TVS) measurement of endometrial thickness (ET) in diagnosing endometrial cancer in postmenopausal women with vaginal bleeding (PMB).Design Retrospective cohort study.Setting One-stop PMB clinic in a Hong Kong teaching hospital. Main outcome measures Accuracy data for TVS ET presented as sensitivity, specificity, and area under the receiver operator characteristic (ROC) curve.Results Endometrial cancer was diagnosed in 3.8% of women. The median ET in those with endometrial cancer was significantly higher than those with benign conditions (15.7 versus 3.2 mm, P < 0.001). The area under the ROC curve was 0.92 (95% CI 0.89-0.94). The sensitivity for the detection of endometrial cancer at 3-, 4-, and 5-mm cut-offs were 97.0% (95% CI 94.5-99.6%), 94.1% (95% CI 90.5-97.6%), and 93.5% (95% CI 89.7-97.2%), respectively. The corresponding estimates of specificity at these thresholds were 45.3% (95% CI 43.8-46.8%), 66.8% (65.4-68.2%), and 74.0% (72.7-75.4%).Conclusions Transvaginal ultrasound using a 3-mm cut-off has high sensitivity for detecting endometrial cancer and can identify women with PMB who are highly unlikely to have endometrial cancer, thereby avoiding more invasive endometrial biopsy.

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Association of Endometrial Cancer Risk With Postmenopausal Bleeding in Women

et al. 2018

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IMPORTANCE As the worldwide burden of endometrial cancer continues to rise, interest is growing in the evaluation of early detection and prevention strategies among women at increased risk. Focusing efforts on women with postmenopausal bleeding (PMB), a common symptom of endometrial cancer, may be a useful strategy; however, PMB is not specific for endometrial cancer and is often caused by benign conditions. OBJECTIVE To provide a reference of the prevalence of PMB in endometrial cancers and the risk of endometrial cancer in women with PMB.

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Endometrial echo complex thickness in postmenopausal endometrial cancer

Cited by 14 publications

References 17 publications

The Use of Transvaginal Ultrasound in Type II Endometrial Cancer

The Use of Transvaginal Ultrasound in Type II Endometrial Cancer

Reappraisal of endometrial thickness for the detection of endometrial cancer in postmenopausal bleeding: a retrospective cohort study

Association of Endometrial Cancer Risk With Postmenopausal Bleeding in Women

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