Endometrial Dye Instillation: A Novel Approach to Histopathologic Evaluation of Morcellated Hysterectomy Specimens

Tam, Teresa; Harkins, Gerald; Caldwell, Trevor; Zaino, Richard J.; Hazard, Danielle

doi:10.1016/j.jmig.2013.04.009

Cited by 5 publications

(3 citation statements)

References 13 publications

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“…In the morcellated specimens 20% of the malignancies were not detected and oncologic staging was not possible in all cases [ 24 ]. In order to aid the pathologist in identifying the endometrial layer Tam et al described a technique to stain the endometrium before morcellation [ 25 ]. In addition benign disseminated uterine tissue can transform to premalignant and malignant tumors years after the initial surgery.…”

Section: Discussionmentioning

confidence: 99%

Laparoscopic Supracervical Hysterectomy with In-Bag Morcellation in Very Large Uterus

Krentel

Wilde

2017

Case Reports in Medicine

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Laparoscopic supracervical hysterectomy (LASH) is a safe and fast minimally invasive approach in hysterectomy. In order to extract the uterine body from the abdominal cavity, one condition for LASH is the morcellation of the tissue. The intra-abdominal dissemination of benign and occult malignant uterine cells is a possible risk of this method, which can be avoided by the use of special bags for laparoscopic in-bag morcellation. We present a case of laparoscopic supracervical hysterectomy with in-bag morcellation in a uterus of more than 1400 g. and describe that this minimal-access surgery is safe and feasible even in very large uteri. This case report is registered in Research Registry under the UIN researchregistry1810.

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Section: Discussionmentioning

confidence: 99%

Laparoscopic Supracervical Hysterectomy with In-Bag Morcellation in Very Large Uterus

Krentel

Wilde

2017

Case Reports in Medicine

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“…Today, it is officially recognized that endometrial hyperplastic processes are one of the important and potentially health-damaging medical problems that challenge doctors around the world [23,24]. A steady increase in the number of patients suffering from endometrial hyperplastic processes, unclear etiology, variable clinical manifestations and a high recurrence rate and risk of malignancy, as well as low treatment efficacy have led to the fact that in recent years, the scientific interest in this problem has increased significantly [25].…”

Section: T H E O R E T I C a L And E X P E R I M E N Tal M E D I C I N Ementioning

confidence: 99%

Features of Endometrium Structure in Alcohol-Abusing Hiv-Infected Individuals

Lytvynenko

2021

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Background. Patients with comorbid pathology occupy leading positions in the practice of a doctor of any specialty especially in patients with HIV. Reproductive system is known to be the gateway for viruses. This fact could explain the severity of changes developing in the female reproductive system infected with HIV, in particular in the endometrium. The purpose of this study was to assess morphological changes in the endometrium caused by the combined effects of HIV infection and chronic alcoholism. Materials and methods: The study included sectional material taken from 60 women of reproductive age (20-40 years). They were all divided into two groups. The first group (30 people) consisted of HIV-positive individuals who, according to a survey of relatives and according to an autopsy (the main symptom is the presence of alcoholic cirrhosis of the liver), alcohol abuse was confirmed. The following parameters were determined: the average diameter of the endometrial glands (proliferative type), the minimum diameter of the endometrial glands (proliferative type), the maximum diameter of the endometrial glands (proliferative type), wall thickness (proliferative type), the relative volume of the epithelium (proliferative type), the average diameter of the glands (secretory type), the minimum diameter of the glands (secretory type), the maximum diameter of the glands (secretory type), the relative volume of the epithelium (secretory type), the thickness of the epithelium. Results. the average diameter of the endometrial glands (proliferative type) decreased from 51.71 ± 2.90 x 10-6 m in the comparison group to 39.42 ± 2.35 x 10-6 m in the HIV-infected group, which was 23.77%. The minimum diameter of the endometrial glands (proliferative type) reduced from 32.47 ± 1.83 x10-6 m to 27.13 ± 1.73x10-6 m (16.45%), the maximum diameter from 72.14 ± 2.21 x10-6 m to 63.84 ± 3.29 x10-6 m (11.5%). the relative volume of the epithelium (proliferative type) decreased by 5.41% (from 54.43 ± 1.79% in the study group to 49.02 ± 2.65% in the control group). The thickness of the uterine wall was also significantly reduced from 15.18 ± 1.60 x10-6 m to 14.52 ± 1.19 x10-6 m, which was 4.35%. The maximum volume of glands (secretory type) changed from 127.98 ± 2.10 x10-6 m to 97.18 ± 3.12 x10-6 m (24%). Changes by 3.6% were also observed when examining the wall thickness (from 13.02 ± 1.36 x10-6 m to 12.55 ± 1.68 x10-6 m). Conclusion. The study evaluated features of endometrial restructuring in alcohol-abusing HIV-infected women.

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“…In general, it is recommended that in such cases a preoperative endometrial biopsy is performed to exclude such a possibility. Although the use of endometrial dye instillation, either trypan blue or methylene blue 76,77, has been proposed as a useful technique to facilitate the identification of the endometrium in morcellated hysterectomies, this is not commonly done. When an occult cancer is picked up in a morcellated specimen, it may be very difficult to assess the depth of myoinvasion and thus accurate staging of the endometrial cancer may not be possible 78.…”

Section: How Should a Morcellated Hysterectomy Specimen That Containsmentioning

confidence: 99%

Endometrial Carcinoma, Grossing and Processing Issues: Recommendations of the International Society of Gynecologic Pathologists

Malpica

Euscher

Hecht

et al. 2019

International Journal of Gynecological Pathology

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Endometrial cancer is the most common gynecologic neoplasm in developed countries; however, updated universal guidelines are currently not available to handle specimens obtained during the surgical treatment of patients affected by this disease. This article presents recommendations on how to gross and submit sections for microscopic examination of hysterectomy specimens and other tissues removed during the surgical management of endometrial cancer such as salpingo-oophorectomy, omentectomy, and lymph node dissection—including sentinel lymph nodes. In addition, the intraoperative assessment of some of these specimens is addressed. These recommendations are based on a review of the literature, grossing manuals from various institutions, and a collaborative effort by a subgroup of the Endometrial Cancer Task Force of the International Society of Gynecological Pathologists. The aim of these recommendations is to standardize the processing of endometrial cancer specimens which is vital for adequate pathological reporting and will ultimately improve our understanding of this disease.

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Endometrial Dye Instillation: A Novel Approach to Histopathologic Evaluation of Morcellated Hysterectomy Specimens

Cited by 5 publications

References 13 publications

Laparoscopic Supracervical Hysterectomy with In-Bag Morcellation in Very Large Uterus

Laparoscopic Supracervical Hysterectomy with In-Bag Morcellation in Very Large Uterus

Features of Endometrium Structure in Alcohol-Abusing Hiv-Infected Individuals

Endometrial Carcinoma, Grossing and Processing Issues: Recommendations of the International Society of Gynecologic Pathologists

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