Endometrial Carcinoma of the Prostatic Utricle: A Tumor of Prostatic Origin

Walther, McClellan M.; Nassar, Victor H.; Harruff, Richard C.; Mann, Bob B.; Finnerty, Donald P.; Hewen-lowe, Karlene O.

doi:10.1016/s0022-5347(17)47433-7

Cited by 17 publications

(7 citation statements)

References 12 publications

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“…The prostatic utricle and the uterus are homologous structures. Rare reports of endometrial carcinoma in the prostatic utricle further highlight the shared embryologic origin [23][24][25]. We hypothesized that homology would be conserved at the molecular level, and PTENP1 would be expressed in the endometrial tissues, as has been described for the prostate.…”

Section: Introductionmentioning

confidence: 88%

Phosphatase and tensin homolog (PTEN) pseudogene expression in endometrial cancer: A conserved regulatory mechanism important in tumorigenesis?

Ioffe

Chiappinelli

Pollock

et al. 2011

Gynecologic Oncology

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Objectives-The PTEN pseudogene, PTENP1, was recently shown to play a role in cell proliferation in a prostate cancer model. In the present study, we sought to determine whether PTENP1 is expressed in endometrial cancer (EMCA) cell lines and primary tumors along with the microRNAs (miRNAs) that are predicted to regulate PTEN and PTENP1 transcript levels. Methods-RNA was prepared from six EMCA cell lines, three normal endometrial samples, and 61 primary tumors. TaqMan ® RT-PCR was used to quantitate PTEN expression in all specimens and PTENP1 expression in cell lines, and normal endometrial (NE) samples. PTENP1 expression was evaluated using conventional RT-PCR in primary tumors. MicroRNA profiling was undertaken using NanoString ™ technology in AN3CA and KLE cell lines. The relationship between PTEN transcript levels, PTENP1 expression, and PTEN mutation status were investigated. Results-All NE samples, cell lines, and primary tumors expressed PTEN. PTENP1 transcript was expressed in NE samples, cell lines, and 34 of 61 (56%) primary tumors. The median relative PTEN level was 2.9 arbitrary expression units in PTENP1-positive tumors and 2.3 in PTENP1negative tumors (p = 0.09). PTEN levels in wild-type and haploinsufficient tumors were variable compared to PTEN-null tumors (p = 0.015). Four microRNAs predicted to bind to PTEN/PTENP1 ranked in the top 20 most abundant microRNA subtypes in the AN3CA and KLE cell lines. Conclusions-PTENP1 is expressed in NE and EMCA cell lines, as are PTEN/PTENP1 targeting inhibitory miRNAs (cell lines). Further studies are needed to evaluate the impact of PTEN/PTENP1/miRNA interactions on tumorigenesis regulation in EMCA.

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Section: Introductionmentioning

confidence: 88%

Phosphatase and tensin homolog (PTEN) pseudogene expression in endometrial cancer: A conserved regulatory mechanism important in tumorigenesis?

Ioffe

Chiappinelli

Pollock

et al. 2011

Gynecologic Oncology

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“…Hence, the tumours were found at an early stage. 5,6,17,18,25,26,32,[63][64][65] Some authors even considered DAC as a tumour with no metastatic potential, 29 although mixed ductal-acinar cases were thought to have a worse prognosis, with the acinar component being the outcomedetermining factor. 11,30,33 Further studies have indicated that DAC has poor outcome.…”

Section: Molecular Profilementioning

confidence: 99%

Ductal adenocarcinoma of the prostate: histogenesis, biology and clinicopathological features

et al. 2016

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“…Neuere Untersuchungen lassen vermuten, daß es sich bei dem erstmals von Melicow u. Pachter (15) beschriebenen Endometriumkarzinom des Utriculus prostaticus nicht um ein von dieser Struktur ausgehendes Karzinom, sondern um ein primäres Prostatakarzinom handelt (4,31). NaciiDhom gehört es zur Gruppe der seltenen atypischen Adenokarzinome der Prostata, die ca.…”

Section: Diskussionunclassified

“…Das durchschnittliche Patientenalter liegt zwischen 61 und 87 Jahren (31). Häufigste Leitsymptome sind irritative oder obstruktive Miktionsbeschwerden, gelegentlich eine Makrohämaturie.…”

Section: Diskussionunclassified

“…Die bildgebenden Verfahren (Sonographie, Ausscheidungsurogramm, Computertomographie) ermöglichen Angaben zur Ausdehnung und Lokalisation und erlauben eine Differenzierung zystischer oder solider Anteile. Trotz multimodaler Bildgebung ist jedoch häufig eine sichere Artdiagnose nicht möglich: bei ausgedehnten Tumoren wie in unserem Fall kann das Epizentrum des Tumors nur vermutet werden, bei organbegrenztem Tumor ist weder computertomographisch noch kernspintomographisch eine Differenzierung zwischen malignen und benignen Geweben möglich (18,27,(30)(31)(32)34). Urethrozystoskopisch imponieren die Tumoren papillär und exophytisch wachsend.…”

Section: Diskussionunclassified

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Das Endometriumkarzinom der Prostata. Primäres Prostatakarzinom oder Karzinom des Utriculus prostaticus?

Weingärtner¹,

Ramaswamy²,

Leppek³

et al. 1994

Aktuel Urol

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Endometrial Carcinoma of the Prostatic Utricle: A Tumor of Prostatic Origin

Abstract: Endometrial carcinoma of the prostatic utricle previously was believed to be of müllerian origin. We report 2 cases studied by ultrastructural and immunoperoxidase techniques. Our results, as well as those presented by others, demonstrate the prostatic origin of this tumor.

Cited by 17 publications

References 12 publications

Phosphatase and tensin homolog (PTEN) pseudogene expression in endometrial cancer: A conserved regulatory mechanism important in tumorigenesis?

Phosphatase and tensin homolog (PTEN) pseudogene expression in endometrial cancer: A conserved regulatory mechanism important in tumorigenesis?

Ductal adenocarcinoma of the prostate: histogenesis, biology and clinicopathological features

Das Endometriumkarzinom der Prostata. Primäres Prostatakarzinom oder Karzinom des Utriculus prostaticus?

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