Endometrial carcinoma metastatic to the vulva: A case report and review of the literature

Giordano, Giovanna; Gnetti, Letizia; Melpignano, Mauro

doi:10.1016/j.prp.2005.08.006

Cited by 17 publications

(45 citation statements)

References 12 publications

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“…A systematic English-language literature search on PubMed between 1966 and 2013 using the terms ‘endometrial carcinoma’, ‘skin’, ‘cutaneous’, ‘metastasis’ and ‘spread’ identified only 26 cases of cutaneous metastasis in endometrial cancer [13-19]. Most of these reports emphasize the rarity of this pattern of dissemination.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous metastasis in endometrial cancer: once in a blue moon – case report

et al. 2014

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BackgroundCutaneous metastases from internal malignancies are uncommon. Moreover, endometrial carcinoma rarely metastasizes to the skin, with a reported prevalence of 0.8%. Here, we report the case of a 62-year-old woman who developed cutaneous metastases from an endometrial carcinoma.Case presentationWhen admitted to our department, the patient underwent a biopsy that showed the presence of cutaneous metastasis in relation to her initial endometrial cancer, diagnosed 3 years earlier. Thereafter, she was treated with a bilateral uterine artery embolization and chemotherapy. The patient had complications and survived 5 months after the diagnosis of the cutaneous metastasis. She died from sepsis.ConclusionCutaneous metastases of the endometrial carcinoma are usually incurable and suggest an unfortunate prognosis where palliation is the mainstay of patient management.

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Section: Discussionmentioning

confidence: 99%

Cutaneous metastasis in endometrial cancer: once in a blue moon – case report

et al. 2014

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“…[3][4][5][6][7] Endometrial carcinoma metastasizing to the vulva is a rare occurrence, with only 15 reported cases in the literature. 8,9 However, there have been no reported cases of endometrial carcinoma as a donor tumor of tumor-totumor metastasis. We report a case of a tumor-to-tumor metastasis with endometrial carcinoma as the donor and a squamous cell carcinoma of the vulva as the recipient.…”

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confidence: 99%

Tumor-to-Tumor Metastasis With Endometrial Carcinoma Metastatic to Squamous Cell Carcinoma of Vulva: The First Reported Case

Wimmer

Coffey

Kaplan

et al. 2013

Archives of Pathology &Amp; Laboratory Medicine

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Endometrial carcinoma metastasizing to the vulva is a rare occurrence, with only 15 reported cases in the literature. To our knowledge, no cases of tumor-to-tumor metastasis involving endometrial carcinoma as a donor tumor have ever been published. We report the first case of an endometrial carcinoma as a donor tumor metastasizing to a squamous cell carcinoma of the vulva, a recipient tumor. A 79-year-old woman with a history of endometrioid adenocarcinoma of the uterus presented with a vulvar lesion. Pathologic examination of the excised lesion confirmed the presence of metastatic endometrioid adenocarcinoma; however, it was found within a well-differentiated squamous cell carcinoma of the vulva. Surrounding the squamous cell carcinoma was a background of a high-grade vulvar intraepithelial lesion (vulvar intraepithelial neoplasia 3), and immunohistochemistry confirmed the presence of 2 separate tumors involved in a tumor-to-tumor metastasis. This unique case highlights the importance of awareness of the phenomenon, and expands the current spectrum of tumor-to-tumor metastases.

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“…Nineteen VM-cases were found [5][6][7][8][9][10][11][12][13][14] (Table 1), excluding a case [7] lacking information.…”

Section: Resultsmentioning

confidence: 99%

Solitary Vulvar Metastasis from Early Stage Endometrial Cancer: Case Report and Literature Review

Mandato

Mastrofilippo

Palicelli

et al. 2020

Preprint

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Abstract BackgroundEndometrial cancer is the most common gynaecological malignancy in developed countries. It is usually diagnosed at early-stage and presents a favourable prognosis. Conversely, advanced or recurrent disease result in low response to therapy and poor outcome. Most recurrences occur within two years postoperatively, typically in pelvic and para-aortic lymph nodes, vagina, peritoneum, and lungs; unusual localizations include abdominal organs/wall, bones, brain, muscle. Vulvar metastasis are indeed anecdotal probably because the different regional lymphatic drainage from corpus uterus. Here, we report a case of vulvar metastasis from an early endometrial cancer comprehensive staged by laparoscopy and reviewed the literature discussing the different mechanisms of vulvar metastasis pathogenesis and the prognosis.MethodsWe reported a case of vulvar metastasis from an early stage endometrial cancer. We also collected and analysed articles written in English regarding vulvar metastasis form endometrial cancer published between January 1966 and May 2020. PubMed was used as a database for this search. Clinical and pathological characteristics, treatments and outcomes were assessed.In total, 19 cases of vulvar metastasis from endometrial cancer were found. Patients had a mean age of 66 years and were mostly asymptomatic. Labium major was the most common and usually unique site of metastasis. Vulvar metastasis were mostly nodular/mass-like lesions occurred in patients treated mostly for endometrial cancer at early stage. Median time to vulvar metastasis was ten months. Most of the metastasis were treated with surgery or radiotherapy. One third of patients presented a subsequent recurrence on average 11 months later. 61.1% of patients died of disease and 70 median overall survival was 16 months.Vulvar metastasis can show different appearance, occurring as single or diffuse lesions on healthyor injured skin, in patients treated for both early- and advanced-stage endometrial cancers. Surgicalapproach seems not to influence the risk of subsequent metastasis, but tumor seeding and vaginalinjuries should be avoided. Whether isolated or associated with recurrence in other locations, vulvarmetastasis are characterized by severe prognosis despite radical treatment. Therefore, any suspectedvulvar lesion arisen during endometrial cancer follow-up should be biopsied, despite the vulva represents an unusual metastatic site.ConclusionsVulvar metastasis can show different appearance. Surgical approach seems not to influence the risk of subsequent metastasis. Vulvar metastasis are characterized by severe prognosis despite radical treatment. Therefore, any suspected vulvar lesion arisen during follow-up should be biopsied.

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Endometrial carcinoma metastatic to the vulva: A case report and review of the literature

Cited by 17 publications

References 12 publications

Cutaneous metastasis in endometrial cancer: once in a blue moon – case report

Cutaneous metastasis in endometrial cancer: once in a blue moon – case report

Tumor-to-Tumor Metastasis With Endometrial Carcinoma Metastatic to Squamous Cell Carcinoma of Vulva: The First Reported Case

Solitary Vulvar Metastasis from Early Stage Endometrial Cancer: Case Report and Literature Review

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