Endometrial carcinoma in premenopausal women: A clinicopathological study

Endometrial carcinoma in women under 40 years of age: incidence of ovarian carcinoma and ovarian metastasis

“…[1][2][3] Our comparison of the younger with the group aged 40 years or more did not show differences in the distribution of clinical stage I, histopathological differentiation, degree of myometrial invasion, and existence of lymph-vascular invasion. Unlike findings in other reports, [5][6][7][8][9][10][11][12][13][14] we found no increase in lowgrade and minimally invasive carcinoma among the younger patients with endometrial carcinoma. Of the ten patients in group A who had pelvic lymphadenectomy, five had lymph node metastasis, a high lymph node positivity rate, similar to that in the recent reports of Gitsh et al 2 and Evans-Metcalf et al 3 In contrast, the percentage of patients with stage IV disease was significantly higher in the younger patients (21.4% for group A vs 2.2% for group B).…”

“…Contrary to previous reports that younger patients with endometrial carcinoma had a better prognosis, [5][6][7][8][9][10][11][12][13][14] we found that the 5-year survival rate after therapy in our study was 85.7% for patients in group A and 91.4% for those in group B, showing no significant difference. Despite the higher incidence of ovarian carcinoma and ovarian metastasis with endometrial carcinoma in group A, they had a similar prognosis to that in group B.…”

“…[1][2][3][4][5] Previous reports have shown that endometrial carcinomas in younger patients included many low-grade and minimally invasive carcinomas, and thus yielded a better prognosis. [5][6][7][8][9][10][11][12][13][14] Reports by Gitsh et al 2 and Evans-Metcalf et al, 3 however, suggested that there were no significant differences in the distribution of clinical stage and survival rates between aged and younger patients, demanding renewed investigation. The in investigations also revealed a high incidence of malignant ovarian tumor associated with endometrial carcinomas in younger patients.…”

Prognostic Factors for Uterine Cancer in Reproductive-Aged Women

“…To provide a means of comparison with previous reports, we chose age 40 as a cutoff based on these prior publications. [42][43][44] Clearly, there is no specific age group that defines young versus older patients. Due to the large numbers of patients, we were able to divide the study cohort and perform subset analyses stratified by various prognostic factors.…”

Dysfunctional Uterine Bleeding

“…Nearly 40% of premenopausal women with endometrial carcinoma will present with menorrhagia as their only complaint. 7 Systemic diseases are another important group to consider, including coagulation disorders (thrombocytopathies, Von Willebrand's disease, and leukemia), hypothyroidism, systemic lupus erythematosus, and cirrhosis. Only a small proportion of menorrhagia cases are caused by systemic disease, but severe consequences could result if the diagnosis were missed.…”