Endometrial cancer in Asian and American Indian/Alaskan Native women: Tumor characteristics, treatment and outcome compared to non-Hispanic white women

Mahdi, Haider; Schlick, Cary Jo R.; Kowk, Li-Lian; Moslemi-Kebria, Mehdi; Michener, Chad M.

doi:10.1016/j.ygyno.2013.11.028

Cited by 36 publications

(38 citation statements)

References 32 publications

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“…In agreement with studies in other cancer types, we demonstrate that survival disparities attenuate toward null for black patients when appropriate treatment is delivered (12,18,33). Our study also agrees with previous evaluations that demonstrate no survival disparities for Hispanics after adjustment for age (34)(35)(36), and with literature that show improved survival associated with API race/ethnicity in other types of cancers (29,37). Despite similarities to other studies, our study is novel because it is one of the first to evaluate differences in treatment and the effect on disparities in AML survival using population-based data (23).…”

Section: Discussionsupporting

confidence: 92%

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How Do Differences in Treatment Impact Racial and Ethnic Disparities in Acute Myeloid Leukemia?

Patel

Mitchell

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: We previously demonstrated disparate acute myelogenous leukemia (AML) survival for black and Hispanic patients; these differences persisted despite younger ages and higher prevalence of favorable cytogenetics in these groups. This study determined: (i) whether there are differences in treatment delivered to minorities, and (ii) how these differences affect outcomes in AML. We hypothesize that differences in treatment explain some proportion of survival disparities.Methods: We used California Cancer Registry data linked to hospital discharge abstracts for patients with AML (1998AML ( -2008. Logistic regression models estimated odds of treatment (chemotherapy and/or hematopoietic stem cell transplant) by race/ethnicity. Cox proportional hazard models estimated mortality by race after adjustment for treatment.

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Section: Discussionsupporting

confidence: 92%

“…In agreement with studies of treatment disparities in other cancer types, we found differences in the receipt of treatment for various racial/ethnic groups (12,14,17,18,29). Our results also support the assertion in previously published studies that disparities may be eliminated by equalizing access to services (20,(30)(31)(32).…”

Section: Discussionsupporting

confidence: 92%

How Do Differences in Treatment Impact Racial and Ethnic Disparities in Acute Myeloid Leukemia?

Patel

Mitchell

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…In addition to excess incidence of most nonendometrioid endometrial cancers, NHB women have significantly higher (14,15,26,33). It is somewhat surprising that Hispanic women do not suffer the same excess burden from endometrial cancer, given that rates of obesity and diabetes are similar to NHB women (34).…”

Section: Discussionmentioning

confidence: 99%

The Growing Burden of Endometrial Cancer: A Major Racial Disparity Affecting Black Women

Coté

Ruterbusch

Olson

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

199

148

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Background: In contrast with the decreasing incidence seen for most cancers, endometrial cancer has been increasing in the United States. We examined whether the increasing incidence and mortality from endometrial cancer are equally distributed by race/ethnicity and tumor histologic subtype.Methods: Surveillance, Epidemiology, and End Results (SEER) endometrial cancer incidence and mortality data were obtained from 2000 to 2011. Age-adjusted incidence and incidence-based mortality rates, 95% confidence intervals, and annual percent changes (APC) were calculated. Rate ratios were calculated to compare racial/ethnic groups. Five-year relative survival rates were presented to explore survival by stage at diagnosis.Results: Incidence rates for endometrial cancers are rising across all racial/ethnic groups, with the greatest APC seen among non-Hispanic black (NHB) and Asian women (APC, 2.5 for both).

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“…Ethnicity is one of the risk factors for developing endometrial cancer and black women have a higher incidence of endometrial cancer. However, a study suggested Asian women with endometrial cancer have improved outcomes and better survival rate compared to non-Asian women [21]. This may be associated with higher positivity of ER or PR in Chinese (Asian) population with endometrial cancer.…”

Section: Discussionmentioning

confidence: 99%

“…However, in this study we also found that the positivity of ER or PR in type 2 endometrial cancer was 72% or 65%, suggesting the majority of endometrial cancer were ER or PR positive regardless of cancer types in Chinese population. We do not know the exact reason why the majority type 2 endometrial cancer were ER or PR positive, but ethnicity may be one of the reasons, because study recently reported that Asian women have improved outcomes and better survival rate in endometrial cancer compared to non-Asian women [21]. …”

Section: Discussionmentioning

confidence: 99%

Is the positivity of estrogen receptor or progesterone receptor different between type 1 and type 2 endometrial cancer?

et al. 2016

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Endometrial cancer is a major cancer in women and traditionally divided into type 1 and type 2. It is well known that type 2 endometrial cancer has a poor prognosis. Studies have suggested that estrogen receptor (ER) or progesterone receptor (PR) positive are positively associated with endometrial cancer survive. However whether the positivity of ER or PR is different between cancer types has not been investigated yet. In this retrospective study, the positivity of ER or PR was analysed in 1054 women with primary diagnosed endometrial cancer taking into account cancer types and menopausal status from the largest university teaching women's hospital in China. The positivity of ER or PR (over 90%) was significantly higher in type 1 compared to that in type 2 endometrial cancer (71% or 64%) in both premenopausal and postmenopausal women. There was no different in positivity of ER or PR in type 1 endometrial cancer between premenopausal and postmenopausal women. However, in type 2 endometrial cancer, the positivity of ER or PR in premenopausal women was significantly higher compared to that in postmenopausal women. Our data demonstrate that both ER and PR positivity are significantly higher in type 1 endometrial cancer (92%) compared to type 2 (72% ER positive, 65% PR positive). Menopausal status is not associated with the positivity of ER or PR in type 1 endometrial cancer. Our data may provide some novel insights why Asian women have better outcomes of endometrial cancer which was reported in the literature.

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Endometrial cancer in Asian and American Indian/Alaskan Native women: Tumor characteristics, treatment and outcome compared to non-Hispanic white women

Cited by 36 publications

References 32 publications

How Do Differences in Treatment Impact Racial and Ethnic Disparities in Acute Myeloid Leukemia?

How Do Differences in Treatment Impact Racial and Ethnic Disparities in Acute Myeloid Leukemia?

The Growing Burden of Endometrial Cancer: A Major Racial Disparity Affecting Black Women

Is the positivity of estrogen receptor or progesterone receptor different between type 1 and type 2 endometrial cancer?

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