Endometrial cancer and obesity: Epidemiology, biomarkers, prevention and survivorship

Fader, Amanda N.; Arriba, Lucybeth Nieves; Frasure, Heidi E.; Gruenigen, Vivian E. von

doi:10.1016/j.ygyno.2009.03.039

Cited by 308 publications

(239 citation statements)

References 45 publications

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“…1 Obesity is known to contribute to increasing rates of commonly occurring cancers including endometrial, where approximately 50-90% of all cases in the United States are attributable to obesity. 2,3 The World Cancer Research Fund published data concluding endometrial cancer to have the highest relative risk (RR = 3.40) of development from obesity with 49% of U.S. diagnoses being preventable. 4 Both premenopausal and postmenopausal obese women have been found to have higher rates of endometrial cancer.…”

Section: Introductionmentioning

confidence: 99%

“…4 Both premenopausal and postmenopausal obese women have been found to have higher rates of endometrial cancer. 3 In addition, increasing rates of obesity appears to be contributing to higher rates of endometrial cancer in the younger age population as well. 5 Many patients who have undergone hysterectomy for endometrial or early-stage cervical cancer require postoperative pelvic radiotherapy with a number of randomized trials showing improvements in local control and progression free survival.…”

Section: Introductionmentioning

confidence: 99%

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Should we customize PTV expansions for BMI? Daily cone beam computerized tomography to assess organ motion in postoperative endometrial and cervical cancer patients

Amini

DeWitt

Vinogradskiy

et al. 2016

Reports of Practical Oncology & Radiotherapy

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Should we customize PTV expansions for BMI? Daily cone beam computerized tomography to assess organ motion in postoperative endometrial and cervical cancer patients

Amini

DeWitt

Vinogradskiy

et al. 2016

Reports of Practical Oncology & Radiotherapy

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“…Endometrial carcinoma is the most common invasive malignant neoplasm of the female genital tract, with an estimated 46,470 diagnosed cases and 8,120 deaths in 2011 in the United States (Cancer Statistics, 2011). Two major types of endometrial carcinoma include type I or endometrioid endometrial carcinoma (EEC) and type II including uterine serous and clear cell carcinomas (Sun et al, 2001;Fader et al, 2009). Cancer is one of the leading causes of death in the world (Zhao et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

The Polymorphism of Hypoxia-inducible Factor-1a Gene in Endometrial Cancer

Kafshdooz¹,

Tabrizi²,

Mohaddes³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: Endometral carcinoma is the most common malignant tumor of the female genital tract and the fourth most common cancer in women after breast, colorectal and lung cancers Hypoxia-inducible factor -1 (HIF-1) is a key transcription factor that regulates cellular response to hypoxia HIF-1 plays important roles in the development and progression of cancer through activation of various genes that are involved in crucial aspects of cancer biology, including angiogenesis, energy metabolism, vasomotor function, erythropoiesis, and cell survival. In this study, we aimed to investigate the association between HIF-1 1772 C/T polymorphisms and endometrial cancer. Materials and Methods: 75 patients with endometrial carcinoma and 75 patients whose underwent hysterectomy for non tumoral indication selected for evaluation of HIF-1 1772 C/T polymorphisms by PCR-RFLP and sequencing. Results: For the 1772 C/T polymorphism, the analysis showed that the T allele and genotype TT were significantly associated with endometrial cancer risk. Conclusions: Our results suggest that the C1772T polymorphism of the HIF-1a may be associated with endometrial cancers.

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“…The incidence of endometrial cancer increases three times in obese women as compared to women with normal weight, a matter that is attributed to the role of obesity in disturbing hormone regulation [40]. Evidence from case studies indicates that fruits and vegetables consumption can reduce the incidence of endometrial cancer in contrast to high fat foods, especially the saturated fat [41].…”

Section: Obesity-cancer Connectionmentioning

confidence: 99%

Obesity and Cancer: What’s the Interconnection?

Faris¹

2015

AOWMC

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Obesity is one of the most prevalent nutritional diseases, associated with chronic morbidity and mortality. Persuasive evidence indicates a striking association between obesity and incidence of common neoplasms, such as those of the esophagus, endometrium, kidney and breast in post menopause women, prostate in men, in addition to colon, rectum and bladder. Such an association has been supported by clinical and laboratory experiments on humans and animals, respectively. The findings have revealed that obesity and increased body fatness, in general and visceral adiposity, in particular, increase the vulnerability to develop different cancers. Although the impact of obesity in cancer progression differs according to the type of cancer, all the obesity-related cancers are centered around body adiposity. This review highlights the different hormonal, biochemical and molecular changes that might be involved in obesity-related cancers. Increased serum insulin, insulin-like growth factor, steroids "sex hormones" and the disturbances in adiponectin and leptin hormones are included. Biochemical and metabolic changes that mediate obesity-related carcinogenesis involving elevated oxidative stress and inflammation levels in the body and the concomitant increment in circulatory proinflammatory cytokines are discussed.

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Endometrial cancer and obesity: Epidemiology, biomarkers, prevention and survivorship

Cited by 308 publications

References 45 publications

Should we customize PTV expansions for BMI? Daily cone beam computerized tomography to assess organ motion in postoperative endometrial and cervical cancer patients

Should we customize PTV expansions for BMI? Daily cone beam computerized tomography to assess organ motion in postoperative endometrial and cervical cancer patients

The Polymorphism of Hypoxia-inducible Factor-1a Gene in Endometrial Cancer

Obesity and Cancer: What’s the Interconnection?

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