Endometrial blood flow is impaired in women with polycystic ovarian syndrome who are clinically hyperandrogenic

Abstract

Objectives To quantify endometrial and subendometrial blood flow in Caucasian women with polycystic ovarian syndrome (PCOS) (VI: 0.57% vs. 1.11% and 0.86%, respectively, both P = 0.01; VFI: 0.14 vs. 0.42 and 0.28, respectively, both P = 0.02) and subendometrial (VI: 1.59% vs. 3.17% and 2.47%, P = 0.01 and 0.02, respectively; VFI: 0.50 vs. 1.67 and 0.96, P = 0.01 and 0.02, respectively)

Effects of Cabergoline administration on uterine perfusion in women with polycystic ovary syndrome

“…14 Pathologic uterine blood flow in PCOS cases caused reduced endometrial receptivity, therefore increased chances of abortion. Accordingly, in PCOS patients, role of certain medication is more important.…”

Effect of metformin treatment on endometrial vascular indices in anovulatory obese/overweight women with polycystic ovarian syndrome using three‐dimensional power doppler ultrasonography

“…This was in agreement with other studies that reported impaired uterine perfusion with elevated impedance to the uterine arterial blood flow in women with PCOS, as well as in women with unexplained infertility and unexplained recurrent pregnancy loss. [20][21][22][23] Metformin has been introduced as a therapeutic option for PCOS, targeting reproductive and cardiometabolic abnormalities on the basis of its action in reduction of glucose levels and attenuation of insulin resistance, as well as its molecular mechanism involving the liver, the muscles, the endothelium, and the ovary. 24 Jakubowicz and coworkers 25 noted that insulin reduction with metformin increases follicularand luteal-phase serum glycodelin and IGFBP-1 concentrations and enhances luteal-phase uterine vascularity and blood flow in PCOS women as demonstrated by a 20% reduction in vascular resistance in spiral arteries.…”

“…In fact, ET-1 is expressed in human endometrium and inversely related to plasma estradiol levels, 19 suggesting that ET-1 and estradiol could operate in concert, modulating endometrial blood flow. It is possible that metformin acts on uterine perfusion by reducing androgen levels 23,30 and thus their vasoconstrictive effect on vascular tissues. 22 Furthermore, metformin administration improves endothelial function in women with PCOS as it improves markers of endothelial activation and coagulation, eg, soluble intercellular adhesion molecule, plasma plasminogen activator inhibitor-1, soluble vascular adhesion molecule, plasma endothelin-1, and E-selectin.…”

Concomitant ovarian drilling and oocyte retrieval by laparoendoscopic single‐site surgery led to live birth using in vitro maturation of oocyte and transfer of frozen–thawed blastocyst in woman with polycystic ovary syndrome

“…In addition, several conditions in women with recurrent pregnancy loss include high level of serum LH and free testosterone, low luteal progesterone and delayed endometrial development, which are also seen in women with PCOS . Endometrial blood flow was reported to be impaired in hyperandrogenic women with PCOS . In view of these reports, LOD may improve the endometrial development and the subsequent pregnancy outcome after FET by reducing serum androgen level.…”

“…12 Endometrial blood flow was reported to be impaired in hyperandrogenic women with PCOS. 13 In view of these reports, LOD may improve the endometrial development and the subsequent pregnancy outcome after FET by reducing serum androgen level. In this case, oocyte retrieval, LOD and chromotubation were performed by LESS.…”