Endometrial Adenocarcinoma With Pulmonary Recurrence

Abstract

DesCripTionWe present the case of an 83-year-old woman with a history of grade 1 stage IB endometrial cancer (endometrial adenocarcinoma) (figure 1) involving the lower uterine segment. She underwent robotic hysterectomy with right salpingo-oophorectomy followed by brachytherapy. A year and a half later, she presented with difficulty in breathing. A chest X-ray showed 8 mm nodular density in the right lower lobe. The above finding was confirmed with CT. Given the concern for a malignant lesion, positron emission tomography/CT scan was performed, which revealed two metabolically active lung nodules, measuring 1.2 cm in the right middle lobe and other in the right lower lobe measuring 1.2 cm (figure 2). Video-assisted thoracoscopic wedge resection of the right lower lobe lung nodule was performed. The frozen section and histopathology revealed papillary adenocarcinoma (figures 3 and 4); nuclear staining was positive for oestrogen receptors and negative for thyroid transcription factor-1 (figure 5). Thus, primary lung adenocarcinoma was ruled out and diagnosis of metastatic endometrial carcinoma was established. She was then started on systemic chemotherapy with carboplatin and paclitaxel. The incidence of lung metastasis in patients with endometrial cancer is 2.3-4.6%. 1Patients with stage IVB endometrial carcinoma and deep myometrial invasion are at increased risk for lung metastasis.2 The risk factor associated with lung metastasis in our patient was the deep myometrial invasion.3 Surgical resection followed by systemic chemotherapy is the standard of care. Overall survival in patients with

Multiple pulmonary cavitating nodules in female with endometrium adenocarcinoma history – difficulties in differentiation between metastases, sarcoidosis and sarcoid-like reaction. Case report

“…Seo et al [26] also noticed that the incidence of cavitary nodules in primary lung cancers is more common (9%), while the frequency of their occurrence as metastatic lesions is only 4%. Endometrial adenocarcinoma metastases to a pulmonary location are very rare and mainly solid [27]. In the D'Orsi et al [25] study the incidence of pulmonary metastases varied from 3.2% to 4.7%.…”