Endometrial adenocarcinoma with clinical evidence of cervical involvement: Accuracy of diagnostic procedures, clinical course, and prognostic factors

Leminen, Arto; Forss, M.; Lehtovirta, Pentti

doi:10.3109/00016349509009946

Cited by 56 publications

(51 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Negative and positive predictive values of the ECC procedure varied between (87.5%-98.3%) and (15.1%-62.5%) in previous studies [7,10,12,23,25]. These differences can partly be explained by heterogeneity in patient selection and differences in assessment of the curettage.…”

Section: Discussionmentioning

confidence: 81%

“…Numerous studies reported the value of other preoperative staging procedures in diagnosing cervical involvement, such as cervical cytology [7,10,12,22], CT scan [23], transvaginal ultrasonography [12,23] and MRI [23,24]. Cervical cytology, CT and transvaginal ultrasonography showed poor results and are not suitable for detecting cervical involvement [7,10,12,22,23].…”

Section: Discussionmentioning

confidence: 99%

“…In most women endometrial cancer is detected at an early stage as postmenopausal vaginal bleeding is an early presenting symptom. Tumour stage, grade, histological type, depth of myometrial invasion [2][3][4][5][6][7], lymph vascular space invasion (LVSI) [8] and age [4,9] are known prognostic factors in endometrial cancer.…”

Section: Introductionmentioning

confidence: 99%

“…Endocervical curettage (ECC) has been commonly used to assess cervical involvement, but the accuracy of this procedure remains controversial [7,10,11,[14][15][16][17][18][19]. The aim of this study is to investigate the value of ECC as a diagnostic procedure in the preoperative staging of patients with adenocarcinoma of the endometrium prior to primary surgery.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Role of endocervical curettage in the preoperative staging of endometrial carcinoma

Bijen

Bock

Hoor

et al. 2009

Gynecologic Oncology

View full text Add to dashboard Cite

a b s t r a c t a r t i c l e i n f oObjective. The presence of cervical involvement is important to establish a rational treatment for endometrial cancer patients. We investigated the value of preoperative endocervical curettage (ECC) in predicting cervical involvement.Methods. Preoperative ECC of 290 patients with clinical stage I epithelial endometrial cancer was compared with histopathology of the uterus.Results. Amongst all ECCs, 245 (84.5%) were negative and 45 (15.5%) were positive for endometrial cancer. In the uterine specimen, cervical involvement was found in 20% (58/290). PPV and NPV of ECC were 86.7% and 92.2%. False negative and false positive ECC occurred in 6.6% and 2.1%. Of all patients with positive ECC, 46.7% had FIGO stage II disease and 46.7% had extra uterine tumor spread (FIGO III, IV).Conclusion. ECC is an acceptable diagnostic tool to predict the presence or absence of cervical involvement in early stage endometrial cancer patients.

show abstract

Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Role of endocervical curettage in the preoperative staging of endometrial carcinoma

Bijen

Bock

Hoor

et al. 2009

Gynecologic Oncology

View full text Add to dashboard Cite

show abstract

“…Another report analyzing overall survival (OS) in stage II endometrial cancer patients showed that there was no survival benefit in patients treated with RH compared with those treated with TAH [15]. Additionally, a prospective randomized study showed that mRH did not reduce locoregional recurrence [16]. So, the extent of hysterectomy has not been determined in early-stage endometrial cancers.…”

Section: Introductionmentioning

confidence: 99%

Is Modified Radical Hysterectomy Needed for Patients with Clinical Stage I/II Endometrial Cancers? A Historical Control Study

Miyamoto

Takano²,

Aoyama³

et al. 2016

Oncology

View full text Add to dashboard Cite

Objective: The aim of the present study was to assess whether hysterectomy with wider resection could improve survival by preventing local recurrence. Methods: Medical charts of the patients with clinical stage I/II endometrial cancers treated at our hospital between 1990 and 2009 were retrospectively analyzed. The primary endpoint was overall survival (OS), and secondary endpoints were progression-free survival (PFS) and adverse effects according to the type of hysterectomy. Results: A total of 247 patients were identified: 46 patients treated with total abdominal hysterectomy (TAH group) and 201 patients with modified radical hysterectomy (mRH group). No significant differences were observed in OS (p = 0.52) and PFS (p = 0.67) between the two groups. Also, there was no significant difference in the distribution of recurrent sites between the two groups. The patients treated with mRH had a longer operation time and more frequently developed severe adverse events, such as blood loss and lymphedema. Conclusion: In our cohorts, there were no significant differences in both PFS and OS according to surgical procedures, and the mRH group more frequently developed severe adverse events. Overall, clinical benefit was not obtained by mRH in patients with clinical stage I/II endometrial carcinomas.

show abstract

Sensitivity of cervico‐vaginal cytology in endometrial carcinoma: A systematic review and meta‐analysis

Frias-Gomez

Benavente

Ponce

et al. 2020

Cancer Cytopathology

View full text Add to dashboard Cite

Cervico‐vaginal cytology is primarily a cervical cancer screening test. The anatomical continuity of the uterine cavity with the cervix makes the Papanicolaou (Pap) test accessible to evaluate signs of disease shed from the endometrium. Our aim was to determine the sensitivity of routine Pap test in endometrial carcinoma detection and its relationship with clinico‐pathologic factors. We performed a systematic review of studies reporting Pap test results prior to diagnosis of or surgery for endometrial carcinoma between 1990 and 2018 in PubMed or Web of Science. Two independent reviewers extracted data and assessed study quality using an adapted Newcastle‐Ottawa Quality Assessment Scale and Quality Assessment of Diagnostic Accuracy Studies tool. We identified 45 studies including a total of 6599 women with endometrial cancer. Abnormal Pap test results prior to diagnosis of or surgery for endometrial carcinoma were observed in 45% (95% CI, 40%‐50%) of study participants. This percentage was significantly higher among those of non‐endometrioid histology compared with endometrioid subtypes (77% [95% CI, 66%‐87%] vs 44% [95% CI, 34%‐53%], respectively; P heterogeneity <.001). Several clinico‐pathologic factors were related to a higher percentage of abnormal Pap test results, including high‐stage, myometrial invasion >50%, high histological grade, positive peritoneal cytology, presence of lymph node metastasis, cervical involvement, and lymphovascular invasion (P heterogeneity <.05 for all variables). Routine cervical cytology can detect endometrial cancer in almost half of patients, whereas sensitivity is higher among individuals with non‐endometrioid histology or more advanced cancers. This review summarizes the current clinical and prognostic value of cervical cytology in endometrial carcinoma. Recent technological developments using molecular biomarkers may improve accuracy for early cancer detection.

show abstract

Endometrial adenocarcinoma with clinical evidence of cervical involvement: Accuracy of diagnostic procedures, clinical course, and prognostic factors

Cited by 56 publications

References 25 publications

Role of endocervical curettage in the preoperative staging of endometrial carcinoma

Role of endocervical curettage in the preoperative staging of endometrial carcinoma

Is Modified Radical Hysterectomy Needed for Patients with Clinical Stage I/II Endometrial Cancers? A Historical Control Study

Sensitivity of cervico‐vaginal cytology in endometrial carcinoma: A systematic review and meta‐analysis

Contact Info

Product

Resources

About