Endometrial Adenocarcinoma in a 27-Year-Old Woman

Abstract

BackgroundEndometrial adenocarcinoma usually occurs after menopause, but in 2%–14% of cases, it occurs in young patients (less than 40 years of age) who are eager to preserve their fertility. Its treatment includes hysterectomy, bilateral salpingo-oophorectomy and pelvic lymphadenectomy, and, in some cases, radiation therapy.AimTo describe a case of endometrial adenocarcinoma occurring in a young woman and to undertake a literature review of risk factors and therapeutic options proposed for young women wishing to preserve their fertility.CaseWe report a case of endometrial cancer in a 27-year-old woman treated for resistant menorrhagia and cared for in our department as well as in the Salah Azaiez Institute.ConclusionEndometrial adenocarcinoma rarely occurs in young women. In such cases, other therapeutic options can be proposed: progesterone therapy and LH-RH (Luteinzing-Hormone-Releasing-Hormone) agonists therapy in order to preserve fertility in younger patients.

Endometrial adenocarcinoma in a 13-year-old girl

“…The known risk factors for developing endometrial hyperplasia or cancer are obesity, nulliparity, infertility, hypertension and diabetes, and all these factors are also known to be associated with polycystic ovary syndrome [ 8 ]. Our patient also could be diagnosed as polycystic ovary syndrome.…”

“…Hormonal treatment is usually indicated in the case of well differentiated, stage I endometrial cancer, especially in the case with positive progesterone receptors, and the absence of lymphovascular invasion and accompanied ovarian tumor. Medroxyprogesterone acetate (400 to 600 mg/day) and megestrol acetate (160 to 200 mg/day) were usually used for oral treatment [ 8 11 ]. The response rate has been reported as 57% to 75% and the recurrence rate ranges from 11% to 50%.…”

Endometrial adenocarcinoma in two young queens

“…Although conservative treatment with various hormones can be used to preserve fertility in humans (Fadhlaoui and others ), the only recommended treatment for feline uterine neoplasia is ovariohysterectomy. This difference is most likely because (1) failure to routinely evaluate hormone receptors of excised tissues, (2) the rarity of these neoplasms in cats and (3) the lack of a specific staging/classification system for feline uterine neoplasia.…”

Endometrial Carcinoma in a 20 Years Old or Less Female: A Rare Presentation of Four Cases

“…It is relatively rare in the young age group (younger than 40 years old) and accounts only for 2.1-14.4%. Only some cases of younger than 30 years old are published [1][2][3][4][5].…”