Endometrial abnormalities in three sisters from a family with hereditary non‐polyposis colorectal cancer syndrome

Hysteroscopic findings in women at risk of HNPCC. Results of a prospective observational study

“…In the general population, the risk of failure due to cervical stenosis is small in premenopausal women; in postmenopausal women, preparing the cervix ensures success in most cases. Baxter reported a familial case illustrating the usefulness of diagnostic hysteroscopy as a screening tool for endometrial cancer in women at risk of HNPCC [13]. The feasibility of diagnostic hysteroscopy in women at risk of HNPCC was similar to that in the overall population in an earlier study [9].…”

Does a “one-stop” gynecology screening clinic for women in hereditary nonpolyposis colorectal cancer families have an impact on their psychological morbidity and perception of health?

“…The screening protocol used in this study included OPH in addition to the recommended tests (TVS, EB, and CA125). This was justified by the knowledge that HNPCC EC can be present in endometrial polyps and that OPH is superior to TVS alone at detecting focal endometrial lesions (13,27,28) . However, the danger of increasing the complexity of a screening protocol is that the specificity of the process is reduced which increases the number of false positive tests.…”

Cancer de l’endomètre du syndrome HNPCC

“…Cette technique est faisable chez ces patientes [37,38]. Le rationnel de cette méthode repose sur les performances reconnues de l'hystéroscopie pour le diagnostic des cancers, mais aussi des hyperplasies ; ainsi que sa réalisation facile en consultation.…”