Endolysosomal channel TMEM175 mediates antitoxin activity of DABMA
Yu Wu,
Jiamin Huang,
Fei Zhang
et al.
Abstract:DABMA is a chemical molecule optimized from the parent compound ABMA and exhibits broad‐spectrum antipathogenic activity by modulating the host's endolysosomal and autophagic pathways. Both DABMA and ABMA inhibit severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) in a cellular assay, which further expands their anti‐pathogen spectrum in vitro. However, their precise mechanism of action has not yet been resolved. TMEM175 is a newly characterized endolysosomal channel which plays an essential role in t… Show more
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