Endoluminal Repair of Aneurysms Containing Ostia of Essential Branch Arteries: An Experimental Model

Wisselink, Willem; Abruzzo, Frederick M.; Shin, Chung K.; Ramirez, José; Rodino, William; Kirwin, Jon D.; Panetta, Thomas F.

doi:10.1583/1074-6218(1999)006<0171:eroaco>2.0.co;2

Cited by 14 publications

(3 citation statements)

References 18 publications

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“…Vários estudos já desenvolveram modelos de aneurisma de aorta, principalmente em cachorros e porcos. Esses aneurismas foram criados mediante sutura de um remendo de material sintético (PTFE ou Dacron ® ), fáscia, peritônio, intestino e também pela interposição de um seguimento de veia jugular interna bovina conservado em glutaraldeído após a ressecção do segmento de aorta infra-renal [8][9][10][11][12][13] . A vantagem deste último mo-…”

Section: Resultsunclassified

Modelo experimental de aneurisma sacular de artéria ilíaca comum com pericárdio bovino em suínos

et al. 2005

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OBJETIVO: Desenvolver um novo modelo experimental de pseudoaneurisma sacular de artéria ilíaca comum com o uso de remendo de pericárdio bovino em suínos. MÉTODO: Foram utilizados dois suínos da raça Landrace, com peso de 30 kg e do sexo feminino. Os animais foram submetidos a anestesia geral e a laparotomia com acesso extraperitoneal da aorta infra-renal e artérias ilíacas. Após heparinização sistêmica e pinçamento, foram efetuadas arteriotomia longitudinal e sutura do pericárdio bovino em formato de bolsa previamente confeccionada. Os animais permaneceram confinados por 3 semanas e então foram submetidos a arteriografia para avaliação da perviedade do aneurisma e, posteriormente, sacrificados. RESULTADO: Os animais sobreviveram ao experimento e apresentaram aneurismas pérvios no momento do sacrifício. Não houve ocorrência de ruptura de aneurismas. CONCLUSÃO: O modelo proposto é viável e tem potencial para ser utilizado no estudo e desenvolvimento de novas próteses endovasculares.

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Section: Resultsunclassified

Modelo experimental de aneurisma sacular de artéria ilíaca comum com pericárdio bovino em suínos

et al. 2005

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“…In all others, endothelization was incomplete. Some abdominal and iliac aorta models that have been described underwent endothelization 27 , 28 , while others had formation of neointima 29 , 30 . The different flow characteristics of the thoracic aorta, the interval between surgical intervention and data collection and the format of the aneurysm may be responsible for this variation.…”

Section: Discussionmentioning

confidence: 99%

Thoracic aortic aneurysm. An experimental model in pigs

2021

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Purpose To describe an unpublished experimental model of descending thoracic aortic aneurysm in pigs. Methods Ten Landrace female pigs aged 10 to 12 weeks old and with initial weights from 17 to 25 kg were anesthetized and their descending thoracic aortas exposed by fifth intercostal space left thoracotomy. The thoracic aorta was isolated. A 2-cm wide × 2-cm long patch of ready-made bovine pericardium was sewn onto the left anterolateral side of the aorta. After three weeks’ follow-up, a control aortography was taken, and the animals were euthanized. The segment of thoracic aorta containing the aneurysm and the adherent tissues were explanted en bloc. The specimens were stained for histological examination. Results One hundred percent of the animals survived the procedure, and after sacrifice a patent aneurysm was observed in all of them. There were no defects on the suture lines. Weight gain during follow-up was normal. All specimens exhibited intense adventitial reaction with myofibroblasts. There were no complications related to the thoracotomy. Conclusions The descending thoracic aortic aneurysms induced experimentally appear to be stable, were of easy execution, with null mortality and no influence on the animals’ normal development. Furthermore, they have similar characteristics to those observed in human degenerative aneurysms.

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“…The surgical procedure of creating an aneurysm was previously described in a dog model. 4 In short, a longitudinal aortotomy was made and an elliptic artificial patch was sewn onto the aortotomy proximally starting above or at the level of the renal arteries (Fig. 5).…”

Section: Creation Of the Aneurysmmentioning

confidence: 99%

Endovascular Grafting of Complex Aortic Aneurysms with a Modular Side Branch Stent-graft System in a Porcine Model

Linsen

Wisselink

et al. 2004

European Journal of Vascular and Endovascular Surgery

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Endoluminal Repair of Aneurysms Containing Ostia of Essential Branch Arteries: An Experimental Model

Abstract: In an acute animal model, suprarenal aortic aneurysms can be excluded from the circulation with preservation of renal flow using an endoluminally placed aortic stent-graft with separate branch grafts.

Cited by 14 publications

References 18 publications

Modelo experimental de aneurisma sacular de artéria ilíaca comum com pericárdio bovino em suínos

Modelo experimental de aneurisma sacular de artéria ilíaca comum com pericárdio bovino em suínos

Thoracic aortic aneurysm. An experimental model in pigs

Endovascular Grafting of Complex Aortic Aneurysms with a Modular Side Branch Stent-graft System in a Porcine Model

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