Endokrinnaya khirurgiya: «Uzkaya» spetsial'nost' ili nasushchnaya neobkhodimost'?

Dedov, I I; Kuznetsov, N S; Мельниченко, Г. А.; Fadeev, V V; Бельцевич, Д. Г.; Vanushko, V E; Grigor'ev, A Yu; Rozhinskaya, Liudmila; Troshina, E A; Galetyan, G R

doi:10.14341/2306-3513-2008-2-3-5

Cited by 4 publications

(5 citation statements)

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“…Studies carried out previously demonstrated the high prevalence of age-related hypogonadism in patients who had suffered a stroke [22]. At that time, only isolated studies investigated the effect of androgen deficiency in men on the development of stroke and its correction.…”

Section: Introductionmentioning

confidence: 99%

Hypogonadism and its treatment following ischaemic stroke in men with type 2 diabetes mellitus

Morgunov¹,

Денисова²,

Rozhkova³

et al. 2018

The Aging Male

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Premature mortality in Russia is a major socio-economic problem, especially from acute cerebrovascular diseases which constitute 21.4% of the total mortality and is a considerable contributor to chronic disability. Risk of vascular catastrophe is higher in males than females, thought, in part, due to anti-atherosclerotic effects of oestrogens in females whilst an associated age-related deficiency of testosterone is observed in men. Clinical symptoms such as high blood pressure, changes in lipid profile, insulin resistance, obesity, and blood coagulation factors often accompany declining testosterone in males and reduced total testosterone is considered a cardiovascular risk factor. In the present study, the prevalence of hypogonadism in men who had suffered ischaemic stroke was evaluated along with the efficacy of testosterone undecanoate injections (TU) in patients with testosterone deficiency and type-2 diabetes (T2DM) in the acute phase of hemispheric ischaemic stroke. Hypogonadism was present in 66.3% of patients with ischaemic stroke, 50% with T2DM, and 26.3% without T2DM, respectively. TU treatment, at both the 2 and 5-year observation points, demonstrated significant improvements in biochemical, physical, and mental parameters. This supports that testosterone deficiency is a contributing factor in ischaemic events and that long-term testosterone therapy could play an important role in patient recovery.

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Section: Introductionmentioning

confidence: 99%

Hypogonadism and its treatment following ischaemic stroke in men with type 2 diabetes mellitus

Morgunov¹,

Денисова²,

Rozhkova³

et al. 2018

The Aging Male

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show abstract

“…Термин «гиперандрогения» подразумевает избыточный синтез андрогенных гормонов [ 1 ]. В настоящее время проведено множество исследований и представлены данные по распространению гиперандрогении у женщин с такими заболеваниями, как синдром поликистозных яичников (СПКЯ) или врожденная дисфункция коры надпочечников (ВДКН).…”

Section: обоснованиеunclassified

Features of steroidogenesis and arterial hypertension in men in different types of "physiological" male hyperandrogenism

Филатова

Роживанов

Bondarenko

et al. 2023

Probl Endokrinol (Mosk)

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AIM. To reveal the peculiarities of steroidogenesis and arterial hypertension in «physiological» hyperandrogenism in men.MATERIALS AND METHODS. One-stage simultaneous study. The groups of men with hyperandrogenism caused by increased total testosterone (n=34) and those with hyperandrogenism caused by increased dihydrotestosterone (DHT) (n=66) were compared. In determining the type of hyperandrogenism and allocating patients to groups, DHT and total testosterone levels were determined by enhanced chemiluminescence. Subgroups of men with and without arterial hypertension were compared in the group of patients with hyperandrogenism due to an increase in total testosterone. Body mass index, waist circumference, systolic and diastolic blood pressure, pulse, and LH, SBHG, estradiol, blood multisteroid levels by isotope dilution liquid chromatography/tandem mass spectrometry, glucose, blood lipid spectrum, uric acid, creatinine, renin, potassium, sodium, and blood chloride were assessed in all patients. Patients with arterial hypertension additionally underwent daily BP monitoring, albuminuria assessment, electrocardiography, ocular fundus examination. The baseline threshold level of significance was p<0.05. For multiple comparisons, the p significance level was calculated using the Bonferroni correction.RESULTS. Statistically significant differences were found in the levels of 17-hydroxypregnenolone, 17-hydroxyprogesterone, and androstenedione, which were higher in men with elevated levels of total testosterone. No statistically significant differences in other laboratory parameters were found. No cases of increased blood pressure were detected in the group of men with elevated DHT. In the group of men with elevated total testosterone, 23,5% of men with arterial hypertension without targetorgan lesions were identified, while hyperandrogenism was associated with 17,6% of cases. Arterial hypertension associated with hyperandrogenism was characterized by a rise in blood pressure in the early morning hours. Estradiol levels, while remaining within normal limits, were statistically significantly lower in patients with arterial hypertension compared with men with elevated testosterone but without hypertension.CONCLUSION. No cases of arterial hypertension were observed in «physiological» hyperandrogenism due to elevated DHT levels, whereas its incidence in «physiological» hyperandrogenism due to elevated total testosterone was 23,5%. The features of steroidogenesis were increased production of 17-hydroxypregnenolone, 17-hydroxyprogesterone, and androstenedione in men with testosterone hyperandrogenism and decreased estradiol production in patients with arterial hypertension compared with patients without testosterone hyperandrogenism.

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“…Исключительно важную роль как в организме в целом, так и в процессах метаболизма костной ткани играет регуляция обмена кальция [12,13] Кальцитонин, наоборот, снижает уровень кальция и стимулирует выработку новой костной ткани. Достаточное количество кальцитонина необходимо для повышения плотности костей [14].…”

Section: проблеми ендокринної патології № 3 2018unclassified

“…В почках под воздействием кальцитонина усиливается выведение из организма натрия, хлоридов, кальция и фосфатов. Кроме того в регуляции обмена кальция участвуют и другие гормоны: гормоны коры надпочечников, половые гормоны, гормоны щитовидной и паращитовидных желез [13][14][15].…”

Section: проблеми ендокринної патології № 3 2018unclassified

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Malova¹,

Komarova²,

Brechka³

et al. 2018

PEP

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The review examines the role of a wide range of hormones, including estrogens and androgens in the regulation of mineral metabolism — from antenatal formation to puberty and on the background of extinction of hormonal activity in old age. It is shown that the problem of osteoporosis concerns not only orthopedists and gerontologists, but also endocrinologists who must develop their own approaches aimed at reducing the frequency of osteoporotic phenomena.

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Endokrinnaya khirurgiya: «Uzkaya» spetsial'nost' ili nasushchnaya neobkhodimost'?

Cited by 4 publications

References 0 publications

Hypogonadism and its treatment following ischaemic stroke in men with type 2 diabetes mellitus

Hypogonadism and its treatment following ischaemic stroke in men with type 2 diabetes mellitus

Features of steroidogenesis and arterial hypertension in men in different types of "physiological" male hyperandrogenism

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