2001
DOI: 10.1002/jcp.1095
|View full text |Cite
|
Sign up to set email alerts
|

Endoglin: An accessory component of the TGF‐β‐binding receptor‐complex with diagnostic, prognostic, and bioimmunotherapeutic potential in human malignancies

Abstract: Endoglin (CD105) is a cell membrane glycoprotein over-expressed on highly proliferating endothelial cells in culture, and on endothelial cells of angiogenetic blood vessels within benign and malignant tissues. CD105 binds several factors of the Transforming Growth Factor (TGF)-b superfamily, and its over-expression modulates cellular responses to TGF-b1. The complex of experimental ®ndings accumulated in the last few years strongly indicate that CD105 is a powerful marker of angiogenesis, and that it might pla… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

5
165
0
1

Year Published

2002
2002
2017
2017

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 158 publications
(171 citation statements)
references
References 43 publications
5
165
0
1
Order By: Relevance
“…CD105 or endoglin is a more recently recognised endothelial antigen that is strongly expressed on proliferating EC, but little or not on resting EC. Therefore, CD105 represents a powerful marker of neovascularisation (Fonsatti et al, 2000(Fonsatti et al, , 2001). Blood vessel counts using CD105 are a better prognostic factor than CD34 in patients with breast cancer (Kumar et al, 1999).…”
Section: Anti-vegf Mab Reduces Tumour Vdmentioning
confidence: 99%
“…CD105 or endoglin is a more recently recognised endothelial antigen that is strongly expressed on proliferating EC, but little or not on resting EC. Therefore, CD105 represents a powerful marker of neovascularisation (Fonsatti et al, 2000(Fonsatti et al, , 2001). Blood vessel counts using CD105 are a better prognostic factor than CD34 in patients with breast cancer (Kumar et al, 1999).…”
Section: Anti-vegf Mab Reduces Tumour Vdmentioning
confidence: 99%
“…35,36 In CIMF, TGF-b is strongly expressed by megakaryocytes, 37,38 a large proportion of which express CD105.…”
Section: Endoglin In Myelofibrosismentioning
confidence: 99%
“…The genes in Group 1 included a number of protein phosphatases that may act to down-regulate signal transduction pathways that promote cell growth, 56 TGF-␤1, a potent inhibitor of cellular proliferation, 57 and endoglin, a member of the TGF-␤ superfamily of receptors. 58 The genes in Group 1 of Table 4 also include two members of the AP-1 (activating protein-1) family of transcription factors that con- sists of homodimers and heterodimers of Jun (v-Jun, c-Jun, JunB, JunD), Fos (v-Fos, c-Fos, FosB, Fra1, Fra2), Jun dimerization partners (JDP1 and JDP2), or activating transcription factor (ATF2, ATF3, B-ATF) proteins. 59 In contrast to c-Jun, a well-known promoter of cell proliferation, JunB and JunD are both potent negative regulators of proliferation.…”
Section: Expression Profiling Of T(14;18)-positive Cell Lines 131mentioning
confidence: 99%