Endogenous α‐calcitonin gene‐related peptide mitigates liver fibrosis in chronic hepatitis induced by repeated administration of concanavalin A

Abstract

Endogenous alphaCGRP mitigates liver fibrosis in chronic hepatitis induced by repeated administration of Con A. alphaCGRP could be a useful therapeutic target for the treatment of chronic hepatitis.

Calcitonin gene-related peptide regulates mitogen-activated protein kinase pathway to decrease transforming growth factor β1-induced hepatic plasminogen activator inhibitor-1 mRNA expression in HepG2 cells

“…9,24) Thus, inhibiting TGFβ1-induced PAI-1 expression may attenuate hepatic fibrosis induced by obesity and diabetes. Kamiyoshi et al 15) showed that endogenous CGRP, which is widely distributed in a variety of tissues, mitigates hepatic fibrosis in chronic hepatitis. However, the mechanism of the effect of CGRP on the alleviation of hepatic fibrosis remains unknown.…”

“…[13][14][15] CGRP receptors are found in the brain, liver, lung, heart, and spleen. 16) Activation of the receptor produces cAMP, a key messenger for various hormones and neuropeptides; the down-stream target of cAMP in neuroblastoma cells is protein kinase A (PKA).…”

Theophylline, an old drug with multi-faceted effects: Its potential benefits in immunological liver injury in rats

“…To establish a chronic hepatitis induced liver fibrosis model, 20 mg/kg Con A was intravenously injected into the rat's tail veins once a week for either 4 weeks or for 8 weeks [24]. Theophylline was administrated in 20 mg/kg/day by gastric gavage from the beginning of the induction of liver injury [26].…”

Pathophysiological Function of Endogenous Calcitonin Gene–Related Peptide in Ocular Vascular Diseases

“…In earlier studies, we and others 14,23,24 clarified the role of CGRP in the regulation of inflammation. We, therefore, used immunohistological analysis to assess inflammatory cell invasion in choroidal flat mounts on day 7 after laser injury.…”