Abstract:Cancer immunotherapies have greatly improved the treatment of several cancers, albeit a large fraction of patients still does not benefit from such treatments. Personalized therapies are envisioned to lead to improved outcomes, yet they have largely been leveraging neoepitopes arising from missense somatic mutations, and as such primarily patients with relatively high tumor mutational burden (TMB) are suitable. With the goal to enhance and broaden its application, we present a pipeline, ObsERV, for the design … Show more
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