Endogenous vascular synthesis of B-type and C-type natriuretic peptides in the rainbow trout

Johnson, Keven R.; Hoagland, Todd M.; Olson, Kenneth R.

doi:10.1242/jeb.052415

Cited by 8 publications

(3 citation statements)

References 47 publications

(77 reference statements)

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“…This possibility is reinforced by our finding a highly significant correlation between NT-proBNP levels and descending aortic diameter, which is relatively dissociated from direct cardiac effects compared to the ascending aorta. Moreover, there is abundant evidence that BNP exerts direct effects on vascular smooth muscle cells from human and rabbit aorta 16 and recent data suggest it may also be produced by the arterial wall 20 .…”

Section: Discussionmentioning

confidence: 99%

N-terminal pro-brain natriuretic peptide levels and aortic diameters

Gutin¹,

Bakalov²,

Rosing

et al. 2012

American Heart Journal

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Background Women with X-chromosome monosomy, or Turner syndrome (TS), are at increased risk for aortic dilation and dissection. To better understand the pathology and develop tools to monitor the risk of aortic disease, we investigated N-terminal pro brain natriuretic peptide (NT-proBNP) levels in women with TS and healthy female controls. Methods We evaluated NT-proBNP levels in women with karyotype-proven TS and healthy female volunteers in relation to ascending aortic diameter (AAD) and descending aortic diameter (DAD) measured by cardiovascular MRI. Results NT-proBNP levels were strongly and positively correlated with AAD and DAD in both cohorts. The TS group (n = 114, age = 37.4 ± 12 yr) had greater BSA-indexed aortic diameters and higher NT-proBNP levels than the control group (n = 27, age = 46.4 ± 11 yr): 88.3 ± 62.7 vs. 53.5 ± 35 pg/mL; P = 0.0003. Within the TS group, NT-proBNP levels were higher in those with dilated ascending aorta (n = 42; 112.4 ± 75.7 pg/mL) compared to those with normal aortic dimensions (n = 72; 74.2 ± 49 pg/mL, P = 0.0014). Abnormally high BNP levels were seen in 3 of 4 TS women that presented with previously undetected aortic aneurysm and/or dissection. Conclusions NT-proBNP levels are positively associated with aortic diameters in women with and without TS, suggesting a role for BNP in arterial wall homeostasis. Further study is necessary to determine whether NT-proBNP measurement may be used to monitor aortic diameter and/or detect aortic pathology in individuals at risk for aortic disease.

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Section: Discussionmentioning

confidence: 99%

N-terminal pro-brain natriuretic peptide levels and aortic diameters

Gutin¹,

Bakalov²,

Rosing

et al. 2012

American Heart Journal

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“…The absence of a training-induced change in the HR response to the stress suggests that the training had no effect on the activity of the sympathetic innervation of the heart in the stressed rats. Collectively, these results may be interpreted as indicating: 1) that the reduction in the stress-induced BP response seen in the trained SHR was mainly due to an attenuated contractility of resistance vessels and, therefore, 2) that the stressinduced activation of the sympathetic nervous system (as 17) , the production of vascular ANP might also be lowered after running training, a possibility that should be tested in the near future.…”

Section: Discussionmentioning

confidence: 85%

Running training attenuates blood pressure and norepinephrine responses to immobilization stress in spontaneously hypertensive rats

Miyoshi

Watanabe

2013

JPFSM

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We investigated the effects of 4 weeks of running training on the progressive changes in resting blood pressure (BP) and heart rate (HR) that occurred during that period, as well as on the increases in cardiovascular variables and catecholamine levels induced by a novel stress (immobilization stress) in spontaneously hypertensive rats (SHR) and control normotensive Wistar-Kyoto rats (WKY). In addition, rat sensitivity to exogenously infused norepinephrine (NE) was investigated by measuring the induced pressor response. BP was measured by a tail-cuff method (without heating), which is reportedly both sensitive and accurate for noninvasive measurement of BP in conscious rats. Increases in resting systolic BP over the 4-week period were significantly smaller in the trained SHR than in the untrained SHR, but the training had no effect on the changes in resting BP seen in WKY. After the 4-week running training, BP and NE responses to immobilization stress were reduced in the SHR, as was the increase in BP induced by intravenous (IV) infusion of NE. In the WKY, however, neither the BP response to the stress nor that to the IV infusion of NE was changed by running training. These results suggest 1) that such training was beneficial in the SHR, and 2) that the immobilization stressinduced activation of the sympathetic nervous system (as evidenced by the increase in plasma NE) and the sensitivity to NE (as evidenced by the increase in BP induced by exogenous NE) were each attenuated after the 4-week running training in the SHR, with a consequent reduction in the BP response to a novel stress.

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“…9 Therefore, it has been hypothesized that the NP system could be involved in the pathobiology of vascular remodelling and plaque formation in humans, with direct production of NPs constituting a biomechanical response to haemodynamic overload. 10 Furthermore, NP concentrations are associated with the extent of coronary and carotid atherosclerotic involvement, as evaluated by CCS 11 and CIMT, respectively. 12 In hypertensive asymptomatic subjects, NPs have been associated with indices of cardiac and vascular remodelling such as left ventricular hypertrophy, 13 diastolic dysfunction, 14 endothelial impairment 15 and vascular stiffness, 16 although their role in vascular remodelling in patients with hypertension remains unclear.…”

Section: Introductionmentioning

confidence: 99%