Endogenous testosterone and serum lipids in middle-aged men

Mäkinen, Juuso; Perheentupa, Antti; Irjala, Kerttu; Pöllänen, Pasi; Mäkinen, Juha; Huhtaniemi, Ilpo; Raitakari, Olli T.

doi:10.1016/j.atherosclerosis.2007.05.009

Cited by 86 publications

(42 citation statements)

References 38 publications

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“…It has been concluded that in aging men low serum testosterone concentration is associated with a potentially atherogenic lipid profile, characterized by low HDL cholesterol and high triglycerides concentrations [31].…”

Section: Discussionmentioning

confidence: 99%

Decrease in Antioxidant Status of Plasma and Erythrocytes from Geriatric Population

et al. 2012

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Abstract.Background: Ageing is associated with an accumulation of free radical damage, which leads to physiological and clinical modifications. The study aims to find out the status of lipid profile, antioxidant enzymes, malondialdehyde in geriatric population. Patients/methods: The study was conducted on 150 subjects (75 healthy control between the ages of 20-30 years and 75 elderly subjects between ages of 50-70 years as cases). The following parameters were analyzed using the standard reference methods: lipid profile, reduced glutathione, glutathione peroxidase, glutathione reductase, catalase, superoxide dismutase and malondialdehyde.Results: The present study was conducted to estimate the oxidative stress parameters in geriatric population. Highly significant increase in total cholesterol (TC), triglyceride (TG), LDL-cholesterol (LDL-C), VLDL-cholesterol (VLDL-C), malondialdehyde, catalase and decrease in high density lipoprotein cholesterol (HDL-C), reduced glutathione, glutathione peroxidase, glutathione reductase, superoxide dismutase was observed in geriatrics when compared with their younger counterparts. Conclusion: This study concluded that there is enhanced oxidative stress and decreased antioxidant defence in geriatrics as compared to younger subjects which could play an important role in ageing. Dyslipidemia has become one of the important risk factors for the increasing prevalence of cardiovascular diseases. There is lack of awareness on the relationship between blood lipids and the risk of cardiovascular diseases in geriatric population. The strategy of early prevention should be adopted against dyslipidemia.

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Section: Discussionmentioning

confidence: 99%

Decrease in Antioxidant Status of Plasma and Erythrocytes from Geriatric Population

et al. 2012

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“…Subsequently, several nested studies have been carried out on all or selected subpopulations of the TuMAS cohort. [8][9][10][11] sexuAl sympToms, poor life sATisfAcTion AnD increAseD usAge of heAlTh services Are AssociATeD wiTh loh It is generally recognized that androgens, due to their strong anabolic effects, are important not only for the maintenance of male reproductive functions but also for a number of other organ systems such as bone, adipose tissue, muscle, haematopoiesis, brain and skin. The typical symptoms of ageing in men are assumed to be caused by the documented decline of T production with ageing, leading to the array of symptoms of LOH.…”

Section: The Turku Male Ageing Study (Tumas)mentioning

confidence: 99%

“…15,16 All in all, the connections of both endogenous levels of T and T therapy on blood lipids are complicated and evidence exists in both directions. 11,17 The association between T and lipids still lacks strong epidemiological verification. We hypothesised that, in agreement with the increased atherosclerosis in hypoandrogenic men, atherosclerotic alterations could also be found in men with LOH symptoms and decreased T. The objective of the study carried out 11 was thus to determine the association of sex steroid hormones with serum lipids within a subcohort of the TuMAS men.…”

Section: Circulating Testosterone and Serum Lipids In Ageing Menmentioning

confidence: 99%

Late-onset hypogonadism in men. Experience from the Turku Male Ageing Study (TuMAS)

Huhtaniemi

Mäkinen

Perheentupa

et al. 2008

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Interest has arisen during the last 10 years as to the possible connection between the age-related decline in androgen production and symptoms of ageing in men. A new ageing-related syndrome with several descriptive names, such as andropause, male menopause, Partial Androgen Deficiency of the Ageing Male (PADAM) and Late-Onset Hypogonadism (LOH), has been identified. Intensive research into the subject is currently ongoing in multiple, population-based epidemiological studies to explore the connections between testicular endocrine function and the physical, psychic and sexual symptoms of ageing. One of these studies is the Turku Male Ageing Study (TuMAS), conducted in Turku, Finland. This review summarises the recent key findings in this study, with special reference to the correlation of androgen levels with sexual symptoms and cardiovascular risk factors.

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“…Several studies have shown a significant improvement in insulin sensitivity in diabetic men treated with supplemental testosterone [Kapoor et al 2006;Boyanov et al 2003]. Studies have also suggested a link between hypogonadism and cardiovascular disease, which is not surprising given the relationship with hypogonadism and the metabolic syndrome [Basaria, 2008;Makinen et al 2008]. The possibility of a causal relationship between hypogonadism and cardiovascular disease has been demonstrated by finding a direct correlation between low testosterone levels and increased risk of aortic atherosclerosis independent of age, body mass index (BMI), total cholesterol, smoking status, or diabetes [Hak et al 2002].…”

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confidence: 99%

Hypogonadism, ADAM, and hormone replacement

Pinsky¹

2010

Therapeutic Advances in Urology

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Male hypogonadism, or testosterone deficiency syndrome (TDS), results from a failure of the testes to produce adequate androgen. Patients have low circulating testosterone in combination with clinical symptoms such as fatigue, erectile dysfunction, and body composition changes. The cause may be primary (genetic anomaly, Klinefelter's syndrome) or secondary (defect in hypothalamus or pituitary), but often presents with the same symptomatology. In the older patient, androgen deficiency of the aging male (ADAM) is an important cause of secondary hypogonadism because testosterone levels decline progressively after age 40. Hypogonadal patients have alterations not only in sexual function and body composition, but also in cognition and metabolism. Regardless of etiology, hypogonadal patients who are both symptomatic and who have clinically significant alterations in laboratory values are candidates for treatment. The goal of hormone replacement therapy in these men is to restore hormone levels to the normal range and to alleviate symptoms suggestive of hormone deficiency. This can be accomplished in a variety of ways, although most commonly testosterone replacement therapy (TRT) is employed.

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Endogenous testosterone and serum lipids in middle-aged men

Cited by 86 publications

References 38 publications

Decrease in Antioxidant Status of Plasma and Erythrocytes from Geriatric Population

Decrease in Antioxidant Status of Plasma and Erythrocytes from Geriatric Population

Late-onset hypogonadism in men. Experience from the Turku Male Ageing Study (TuMAS)

Hypogonadism, ADAM, and hormone replacement

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