Endogenous Serratia marcescens Endophthalmitis with Dark Hypopyon

Equi, Robert A.; Green, W.Richard

doi:10.1016/s0039-6257(01)00263-6

Cited by 45 publications

(43 citation statements)

References 35 publications

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“…marcescens is a known nosocomial pathogen and can cause a variety of infections in humans including blindness in the susceptible host [17,20,52]. It is thus important to understand its proliferative mechanisms in relation to its existence in the DUWL environment to inform the future development of disinfection regimes.…”

Section: Vermiformis Dominates the Duwl Environment [7] And Their mentioning

confidence: 99%

“…marcescens is known to be a nosocomial pathogen which can acquire antimicrobial resistance [27]. This bacterium can cause a variety of infections in the susceptible host including septicaemia, meningitis, endocarditis and blindness [17,20,52]. Previous work from our laboratory on grazing habits of V. vermiformis [14] indicated that small sized bacteria were favoured as a food source.…”

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confidence: 99%

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Risk Assessment for the Spread of Serratia marcescens Within Dental-Unit Waterline Systems Using Vermamoeba vermiformis

et al. 2015

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(2015) Risk assessment for the spread of Serratia marcescens within dental unit waterline systems using Vermamoeba vermiformis. Current Microbiology, 71 (4). pp. 434 442.It is advisable to refer to the publisher's version if you intend to cite from the work.http://dx.doi.org/10.1007/s00284-015-0872-0For more information about UCLan's research in this area go to http://www.uclan.ac.uk/researchgroups/ and search for . Conflict of interest disclosure statementAll named authors declare that there is no conflict of interest.2 Title: Risk assessment for the spread of Serratia marcescens within dental-unit waterline systems using Vermamoeba vermiformis Abstract:Vermamoeba vermiformis is associated with the biofilm ecology of dental-unit waterlines (DUWLs). This study investigated whether V. vermiformis is able to act as a vector for potentially pathogenic bacteria and so aid their dispersal within DUWL systems. Clinical dental water was initially examined for Legionella species by inoculating it onto Legionella selective-medium plates. The molecular identity/profile of the glassy colonies obtained indicated none of these isolates were Legionella species. During this work bacterial colonies were identified as a non-pigmented Serratia marcescens. As the water was from a clinical DUWL which had been treated with Alpron™ this prompted the question as to whether S. marcescens had developed resistance to the biocide. Exposure to Alpron™ indicated that this dental biocide was effective, under laboratory conditions, against S. marcescens at up to 1x10 8 colony forming units/millilitre (cfu/ml). V. vermiformis was cultured for eight weeks on cells of S. marcescens and Escherichia coli. Subsequent electron microscopy showed that V.vermiformis grew equally well on S. marcescens and E. coli (p = 0.0001). Failure to detect the presence of S.marcescens within the encysted amoebae suggests that V. vermiformis is unlikely to act as a vector supporting the growth of this newly isolated, nosocomial bacterium.

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Section: Vermiformis Dominates the Duwl Environment [7] And Their mentioning

confidence: 99%

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confidence: 99%

Risk Assessment for the Spread of Serratia marcescens Within Dental-Unit Waterline Systems Using Vermamoeba vermiformis

et al. 2015

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“…Serratia marcescens is an aerobic, Gram-negative bacillus that is commonly associated with nosocomial infections of the respiratory and urogenital tract in susceptible individuals. [1][2][3] It is a rare but devastating cause of endogenous endophthalmitis due to its multi-drug resistant nature, resulting in blindness or enucleation in a majority of reported cases. [1][2][3] Herein, we report a case of endogenous Serratia marcescens endophthalmitis with a ciliary body abscess presenting initially as acute angle-closure glaucoma, leading to difficult diagnosis.…”

Section: Sir Endogenous Serratia Marcescens Endophthalmitis: An Atypmentioning

confidence: 99%

“…[1][2][3] Ophthalmologists should suspect atypical infections in such patients, [1][2][3] and for Serratia marcescens endophthalmitis, initiate aggressive intra-vitreal aminoglycoside therapy. [1][2][3] Eye ( …”

Section: Commentmentioning

confidence: 99%

Endogenous Serratia marcescens endophthalmitis: an atypical presentation

Tan

Galvante

Chee

2013

Eye

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“…1,7 Conjunctival infections caused by P. aeruginosa, S. marcescens, and Neisseria spp., all Gram-negative bacteria, are of concern to eye care practitioners due to their severity and potential for sequelae, if not successfully treated. 5,[10][11][12][13][14][15] P. aeruginosa is an opportunistic pathogen and a well-known risk factor for bacterial keratitis; as many as one-third of cases associated with contact lens wear are attributed to P. aeruginosa. [16][17][18] S. marcescens, like P. aeruginosa, is another ubiquitous opportunistic pathogen associated with contact lens-associated keratitis as well as some cases of endophthalmitis.…”

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confidence: 99%

Clinical outcomes with besifloxacin ophthalmic suspension 0.6% in the treatment of bacterial conjunctivitis due to potentially consequential pathogens

Comstock¹,

Morris²,

Gearinger³

et al. 2014

OPTO

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Purpose: Besifloxacin is a chlorofluoroquinolone approved for use in the treatment of bacterial conjunctivitis. This study assessed the clinical efficacy of besifloxacin ophthalmic suspension 0.6% against conjunctivitis infections caused by potentially consequential pathogens. Design: Post hoc analysis of clinical outcomes for patients with conjunctival infections due to Pseudomonas aeruginosa, Serratia marcescens, Neisseria spp., methicillin-resistant Staphylococcus aureus (MRSA), and methicillin-resistant Staphylococcus epidermidis (MRSE) who were treated with besifloxacin in four multicenter, double-masked, randomized clinical trials. Methods: Minimum inhibitory concentrations (MICs) of besifloxacin against potentially consequential pathogens were pooled. Clinical outcome data for patients treated with besifloxacin with baseline infections due to these pathogens were pooled and summarized. Bacterial eradication was defined as the absence of ocular bacterial species present at or above threshold at baseline. Results: A total of 1,317 patients had culture-confirmed bacterial conjunctivitis across the four studies, and 151 infections were due to the aforementioned pathogens (P. aeruginosa n=9; S. marcescens n=10; Neisseria spp. n=16; MRSA n=35; MRSE n=81). Among MRSA and MRSE infections, 48.3% demonstrated concurrent ciprofloxacin resistance (ciprofloxacinresistant [CipR]-MRSA n=24; CipR-MRSE n=32). The MIC 90 (MIC for 90% of isolates) for besifloxacin was 1 µg/mL for S. marcescens, 0.25 µg/mL for Neisseria spp., 0.06 µg/mL for both ciprofloxacin-sensitive MRSA and ciprofloxacin-sensitive MRSE, and 4 µg/mL for both CipR-MRSA and CipR-MRSE. Against P. aeruginosa, the MIC range was 1-4 µg/mL. Bacterial eradication rates in patients treated with besifloxacin were 100% by the first follow-up visit for infections due to P. aeruginosa, S. marcescens, and Neisseria spp. and 87.8% by the second follow-up visit for infections due to MRSA and MRSE. Conclusion: The use of besifloxacin ophthalmic suspension 0.6% in the treatment of conjunctival infections due to potentially consequential pathogens resulted in high rates of bacterial eradication.

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Endogenous Serratia marcescens Endophthalmitis with Dark Hypopyon

Cited by 45 publications

References 35 publications

Risk Assessment for the Spread of Serratia marcescens Within Dental-Unit Waterline Systems Using Vermamoeba vermiformis

Risk Assessment for the Spread of Serratia marcescens Within Dental-Unit Waterline Systems Using Vermamoeba vermiformis

Endogenous Serratia marcescens endophthalmitis: an atypical presentation

Clinical outcomes with besifloxacin ophthalmic suspension 0.6% in the treatment of bacterial conjunctivitis due to potentially consequential pathogens

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