Endogenous retroelement activation is implicated in IFN-α production and anti-CCP autoantibody generation in early RA
Faye AH Cooles,
Gemma V Pedrola,
Najib Naamane
et al.
Abstract:Objectives: Endogenous retroelements (EREs) stimulate type 1 interferon (IFN-I) production but have not been explored as potential interferonogenic triggers in Rheumatoid Arthritis (RA). We investigated ERE expression in early RA (eRA), a period where IFN-I is increased. Methods: ERE expression in DMARD naive eRA whole blood (LINE1, RT-PCR) and bulk synovial tissue (LTR5, LINE1, SINE, Nanostring) was examined alongside IFN-alpha activity. Circulating lymphocyte subsets, including B cell subsets, from eRA patie… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.