Abstract:Reductive genome evolution is commonly observed among host-associated bacteria including many important pathogens, such as Mycobacterium leprae but its molecular mechanism is not well understood. One of the most widely accepted hypotheses to explain bacterial genome reduction is Muller's ratchet, in which the associated bacteria tend to accumulate deleterious mutations for reduction in the absence of chromosomal recombination inside the eukaryotic host organism. Cardinium species belong to the family Amoebophi… Show more
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