Endogenous or Exogenous Origin of Vaginal Candidiasis in Polish Women?

Mnichowska-Polanowskai, Magdalena; Wojciechowska‐Koszko, Iwona; Klimowicz, Bogumia; L, Szymaniak; Krasnodębska-Szponder, Barbara; Szych, Zbigniew; Giedrys-Kalemba, Stefania

doi:10.33073/pjm-2013-042

Cited by 4 publications

(3 citation statements)

References 34 publications

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“…Other researchers have found that carriage of rectal Candida was higher during episodes of vulvo-vaginitis than during periods of remission. 8 Dynamic transmission of yeast by autoinoculation has been documented, 16 emphasizing the potential importance of extra-vaginal carriage, and justifying the use of oral fluconazole maintenance therapy to reduce recurrence rates in women with RVVC. 4 5 However, it does not explain why, according to our findings, systemic therapy failed to prevent Candida vulvo-vaginitis relapses in anal Candida carriers.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Is multiple-site colonization with Candida spp. related to inadequate response to individualized fluconazole maintenance therapy in women with recurrent Candida vulvovaginitis?

Donders¹,

Grincevičienė

Bellen³

et al. 2018

Diagnostic Microbiology and Infectious Disease

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Objective. Although most women on fluconazole maintenance therapy for recurrent vulvovaginal candidosis experience a substantial improvement in quality of life, some do not respond to therapy.Is candidal colonization of extragenital sites related to suboptimal response to maintenance therapy?Patients and Methods. Women included in a multi-centre follow up study(ReCiDiF) were evaluated for clinical signs and presence of yeasts in nose, mouth, anus, perineum and urine.Candida was diagnosed by positive microscopy, confirmed by positive culture or PCR. After treatment, women were divided into groups according to their response to a fluconazole maintenance regimen (optimal, sub-optimal and non-responders).Results. The most frequent extra-vaginal Candida spp. were detected in urine (79.5%), perineum (78.6%), and anus (56.4%). Carriers of Candida in the mouth were more likely to have it in the anus (OR 3.2; 95%CI 1.4-7.7). Colonization in anus (OR 3.3; or in multiple extra-vaginal sites (OR 3.0; CI95% 1.2 -7.4) were related to non-response to therapy. Candidal carriage in the anus did not increase anal and perianal symptoms. Conclusion.Women with anal carriage and multiple site candidal colonization are less likely to respond to individualised decreasing dose fluconazole therapy.

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Section: Accepted Manuscriptmentioning

confidence: 99%

Is multiple-site colonization with Candida spp. related to inadequate response to individualized fluconazole maintenance therapy in women with recurrent Candida vulvovaginitis?

Donders¹,

Grincevičienė

Bellen³

et al. 2018

Diagnostic Microbiology and Infectious Disease

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“…yeasts. The ability to colonize tissue and the nature of infections caused by yeasts depends on the strain-specific features including invasiveness, adhesion and biofilm creation abilities, enzymatic activity and the immune status of the host [1][2][3][4][5][6]. Candida albicans is the main pathogenic species and the most frequent cause of candidiasis in humans.…”

Section: Introductionmentioning

confidence: 99%

Occurrence of Candida Spp. In Healthy Oral Microbiota

Kimsa¹,

Tokarska-Rodak²

2020

hpc

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Authors' contribution Wkład autorów:A. Study design/planning zaplanowanie badań B. Data collection/entry zebranie danych C. Data analysis/statistics dane -analiza i statystyki D. Data interpretation interpretacja danych E. Preparation of manuscript przygotowanie artykułu F. Literature analysis/search wyszukiwanie i analiza literatury G. Funds collection zebranie funduszy Summary Background. Candida is a strain of fungi that is found on the surface of healthy mucous membranes of the oral cavity. Yet, Candida may also be considered opportunistic microorganisms. The pathogenicity of Candida spp. depends on strain-specific characteristics including, invasiveness, adhesion, and production of biofilm abilities as well as the production of enzymes allowing the colonization of tissue. The aim of the paper was to evaluate the frequency of Candida spp. occurrence in the oral microbiota of healthy adults, and its relation with risk factors and colonization. Material and methods. This study consisted of 72 healthy participants (from the Lubelskie Voivodeship between 19 and 73 years of age). Medical history was collected to determine potential relationships to risk factors affecting oral microbiota (past oral cavity diseases, chronic diseases, and smoking). The participants who were qualified had no oral cavity infections during the study. The collected clinical samples (oral cavity swabs) were disseminated on the chromogenic base for isolation and differentiation of Candida spp. Results. The frequency of Candida spp. occurrence was at the level of 63.8%. C. albicans was the most frequently identified species (56.5%). C. glabrata (45.6%) and C. tropicalis (23.9%) were identified less often. In 21.7% of swabs, two species of Candida were identified and in 2.2% of swabs three species identified. The most common colonization risk factor was associated with smoking (32.6%). Conclusions. Yeasts of Candida species are part of the healthy microflora of the oral cavity in people of different ages and may occur as single species or coexist with other species. The coexistence of chronic diseases, propensity for oral cavity infections and smoking significantly influence the Candida colonization. This may result in future clinical consequences, for example in cases of immunodepression.

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“…Candida albicans is responsible for 80% -92% of all vulvovaginal candidiasis cases (VVC) [5]- [7]. However, the frequency of other species as causative agents for this disease is increasing, particularly those with different susceptibility profiles to antifungal agents, possibly because of the indiscriminate use or misuse of these drugs, which may result in recurrent infections [8]- [11].…”

Section: Introductionmentioning

confidence: 99%

Alpha Defensins Genes and Vulvovaginal Candidiasis: A Study of Cases

Boatto¹,

Francisco²,

Kleine³

et al. 2015

OJOG

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Objective: To evaluate the alpha-defensin (α-DF) genes polymorphism in women with vulvovaginal candidiasis and recurrence. Methods: This observational study included clinical vaginal secretion samples collected over four years from 88 women, ranging in age from 18 to 65 years, from medical centers of São Paulo and Mogi das Cruzes, Brazil. Thirty-six of these women were asymptomatic (control group) and 52 presented clinical condition compatible with vulvovaginitis (38 primary or episodic as non-recurrent forms, and 14 recurrent vulvovaginal candidiasis). A portion of each sample was plated on Sabouraud dextrose agar with chloramphenicol and grown on CHROMagar Candida for presumptive characterization. The identification of the species was obtained by sequencing of the ITS1 region of rDNA. α-DF genes were amplified for subsequent evaluation of polymorphisms by endonuclease restriction assay. Results: From 88 samples were isolated 60 Candida albicans and 28 non-albicans Candida spp. Resistant C. albicans strains and non-albicans Candida spp. were more prevalent in recurrence. In all groups, the number of resistant non-albicans Candida spp. was most high than susceptible strains. α-DF1, α-DF3 and α-DF1/α-DF3 genotypes were found in 32 (36.4%), 17 (19.3%), 6 (6.8%) vaginal samples, respectively. About 33 samples were not amplified. Recurrence and severe disease were more observed in homozygous population. Conclusions: Non-albicans Candida spp. and homozygotic α-DF genotipes (α-DF1 and α-DF3) were more related with severe clinical signs and recurrence. Further studies about vulvovaginal candidiasis and α-DF genes are necessary to access the more comprehen-* Corresponding author.

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Endogenous or Exogenous Origin of Vaginal Candidiasis in Polish Women?

Cited by 4 publications

References 34 publications

Is multiple-site colonization with Candida spp. related to inadequate response to individualized fluconazole maintenance therapy in women with recurrent Candida vulvovaginitis?

Is multiple-site colonization with Candida spp. related to inadequate response to individualized fluconazole maintenance therapy in women with recurrent Candida vulvovaginitis?

Occurrence of Candida Spp. In Healthy Oral Microbiota

Alpha Defensins Genes and Vulvovaginal Candidiasis: A Study of Cases

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