1989
DOI: 10.1159/000457594
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Endogenous Opioids May Protect the Perinatal Brain in Hypoxia

Abstract: Endogenous opioids are released in great amounts in perinatal asphyxia. The role of this release has been unclear. In a study of cerebral blood flow and oxygen metabolism in 5 hypoxic newborn lambs, naloxone blocking of opioid receptors resulted in a proportional increase in telencephalic cerebral blood flow and oxygen metabolism. It is suggested that endogenous opioid release protects the neonatal brain in hypoxia by diminishing the cerebral metabolic rate of oxygen.

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Cited by 10 publications
(1 citation statement)
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“…b) Psychotropic properties of substances in the contractile-inhibitory system, along with morphinelike opiates (endorphins, enkephalin) produced by brain neurons. The production of these opiates increases progressively during labor, peaking as the baby passes through the vulvar ring [59], [60], [61], [62].…”
Section: Psychological State Of a Woman And Her Child During Childbirthmentioning
confidence: 99%
“…b) Psychotropic properties of substances in the contractile-inhibitory system, along with morphinelike opiates (endorphins, enkephalin) produced by brain neurons. The production of these opiates increases progressively during labor, peaking as the baby passes through the vulvar ring [59], [60], [61], [62].…”
Section: Psychological State Of a Woman And Her Child During Childbirthmentioning
confidence: 99%