Endogenous opioid blockade and gonadotropin secretion: role of pulsatile luteinizing hormone-releasing hormone administration in anorexia nervosa and weight loss amenorrhea

Giusti, Massimo; Torre, R. La; Traverso, Laura; Cavagnaro, P.; Attanasio, Roberto; Giordano, Giulio

doi:10.1016/s0015-0282(16)59886-0

Cited by 25 publications

(8 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar results of opioid‐mediated inhibition of hypothalamic function were also observed in experiments with fasting rats 28 . However Giusti et al 29 observed no correction of luteinising hormone pulsatility after the administration of another opioid antagonist, naltrexone. Dopamine is also known to inhibit luteinising hormone secretion.…”

Section: Endocrine Mechanisms Of Amenorrhoeasupporting

confidence: 57%

The reproductive endocrine consequences of anorexia nervosa

Katz

Vollenhoven

2000

BJOG

View full text Add to dashboard Cite

Section: Endocrine Mechanisms Of Amenorrhoeasupporting

confidence: 57%

The reproductive endocrine consequences of anorexia nervosa

Katz

Vollenhoven

2000

BJOG

View full text Add to dashboard Cite

“…These necessary comparisons have not been made in many of the previous studies examining the ability of naloxone to reverse the suppression of LH secretion oc curring in periods of chronic undernutrition. Such reports of increased LH secretion in response to naloxone in women with anorexia nervosa [32][33][34] or undernourished rats [35], may therefore reflect antagonism of the normal inhibitory tone of endogenous opioid peptides rather than antagonism of the active suppression of LH secre tion by opioid peptides during undernutrition. In several studies where LH responses to naloxone have been com pared in normally fed and chronically undernourished animals, it has been found that naloxone was unable to restore LH secretion to levels found in fed animals [36,37], The only study with differing results is one by Dyer et al [38].…”

Section: Discussionmentioning

confidence: 99%

Suppression of Luteinizing Hormone Secretion during Food Restriction in Male Rhesus Monkeys (<i>Macaca mulatta</i>): Failure of Naloxone to Restore Normal Pulsatility

Helmreich¹,

Cameron²

1992

Neuroendocrinology

View full text Add to dashboard Cite

Short periods of fasting have been shown to cause a significant slowing of pulsatile LH secretion in men and male rhesus monkeys, which appears to result from a slowing of GnRH drive to the reproductive axis. To determine whether an increased activity of endogenous opioid peptides causes this slowing of pulsatile LH secretion, the ability of naloxone administration to reverse the fasting-induced suppression of LH secretion was tested. For this study, 6 adult male rhesus monkeys, with indwelling femoral and jugular venous catheters, were maintained on tether/swivel systems. Naloxone was administered to monkeys as a continuous infusion (0.25 mg/kg/h, with an initial loading dose of approximately 1.0 mg) for 8 h (16.00 to 24.00 h) on a day of normal feeding and again on a day of fasting. The LH response to naloxone was determined by collecting blood samples every 15 min from 12.00 to 24.00 h. LH pulse frequency on a day of normal feeding was 4.0 ± 0.52 pulses/8 h, and naloxone administration on a day of feeding increased LH pulse frequency to 6.8 ± 0.86 pulses/8 h. On a day of fasting, LH pulse frequency was 1.67 ± 0.67 pulses/8 h, and naloxone administration on a day of fasting slightly, but not significantly, increased LH pulse frequency to 2.5 ± 0.51 pulses/8 h. Similar studies were performed with a higher dose of naloxone (0.625 mg/kg/ h, with an initial loading dose of approximately 2.0 mg) and again naloxone administration did not reverse the effects of fasting on pulsatile LH secretion. These results suggest that the slowing of pulsatile LH release that occurs with short periods of food restriction does not result from increased secretion of endogenous opioid peptides.

show abstract

“…The diurnal and pulsatile variation of gonadotropin secretion in AN resembles that of the prepubertal stage 34 ' 168 (Fig. The immature LH secretion pattern can be induced via experimental starvation of healthy subjects 169 , and in AN it can be normalized by pulsatile administration of low doses of gonadotropinreleasing hormone (GnRH) 35,170 . The immature LH secretion pattern can be induced via experimental starvation of healthy subjects 169 , and in AN it can be normalized by pulsatile administration of low doses of gonadotropinreleasing hormone (GnRH) 35,170 .…”

Section: The Ovarian Axismentioning

confidence: 99%

Update on Endocrine Disturbances in Anorexia Nervosa

Støving¹,

Hangaard²,

Hagen³

2001

Journal of Pediatric Endocrinology and Metabolism

View full text Add to dashboard Cite

The marked endocrine changes that occur in anorexia nervosa have aroused a great deal of interest, and over the last decade much research has been conducted in this field. The endocrine disturbances are not specific to this disorder, as they also occur in starvation states secondary to other causes, and they return to normal upon weight restoration. However, emaciation may have profound effects on psychological processes, establishing an intricate circular interaction whereby somatic and psychological manifestations of starvation may continue to act. The purpose of this paper is to provide an overview of the large body of literature concerning endocrine aspects of anorexia nervosa with the main focus on the latest results, which provide leads for potential etiological theories.

show abstract

Endogenous opioid blockade and gonadotropin secretion: role of pulsatile luteinizing hormone-releasing hormone administration in anorexia nervosa and weight loss amenorrhea

Cited by 25 publications

References 20 publications

The reproductive endocrine consequences of anorexia nervosa

The reproductive endocrine consequences of anorexia nervosa

Suppression of Luteinizing Hormone Secretion during Food Restriction in Male Rhesus Monkeys (<i>Macaca mulatta</i>): Failure of Naloxone to Restore Normal Pulsatility

Update on Endocrine Disturbances in Anorexia Nervosa

Contact Info

Product

Resources

About