Endogenous Opiates and Behavior: 2018

Bodnar, Richard J.

doi:10.1016/j.peptides.2020.170348

Cited by 19 publications

(11 citation statements)

References 940 publications

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“…The opioid peptides and their receptors are densely expressed in the projections that innervate the amygdala, thalamus, cerebral cortex, and hippocampus, which are considered the primary brain areas implicated in the pathophysiology of neuropsychiatric disorder. , Notably, it seems that the stimulation of MOR initiates several adaptations that occur at the cellular, synaptic, and network levels in the central nervous system, resulting in an antinociceptive behavior, euphoria, and enhanced mood. , Preclinical studies have suggested a role of MOR on the phenotypes related to depression, and therefore, MOR modulators might be a feasible target to treat mood disorders . In this way, a previous study reported that a single morphine injection at a dose of 5 mg/kg reduced the immobility time of mice in the FST, reflecting an antidepressant-like effect …”

Section: Resultsmentioning

confidence: 99%

Contribution of Opioid and Nitrergic Systems to m-Trifluoromethyl diphenyl Diselenide Attenuates Morphine-Induced Tolerance in Mice

Martins

Rosa

Zborowski

et al. 2022

ACS Chem. Neurosci.

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m-Trifluoromethyl diphenyl diselenide (TFDD) has antinociceptive and antidepressant-like properties and attenuates morphine withdrawal signs in mice. This study investigated if TFDD affects the development of morphine tolerance to its antinociceptive and antidepressant-like effects in mice. We also investigated whether TFDD modulates signaling pathways related to morphine tolerance, including the opioid receptors and some parameters of the nitrergic system. Male adult Swiss mice received morphine alone (5 mg/ kg, subcutaneous) and in combination with TFDD (10 mg/kg, intragastric) for 7 days. Mice were subjected to hot plate and forced swim tests on days 1, 3, 5, and 7 of the experimental protocol. Repeated TFDD administrations avoided tolerance development mediated by morphine, including its antinociceptive and antidepressant-like effects. A single morphine dose increased MOR and NOx but decreased iNOS contents in the mouse cerebral cortex. In turn, single morphine and TFDD co-administration restored the MOR and iNOS protein levels. On the other hand, morphine repeated doses enhanced DOR and reduced MOR and NOx contents, whereas the morphine and TFDD association reestablished DOR and NOx levels in the mouse cerebral cortex. In conclusion, some opioid and nitrergic system parameters might contribute to TFDD attenuation of antinociceptive and antidepressant-like tolerance induced by morphine in mice.

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Section: Resultsmentioning

confidence: 99%

Contribution of Opioid and Nitrergic Systems to m-Trifluoromethyl diphenyl Diselenide Attenuates Morphine-Induced Tolerance in Mice

Martins

Rosa

Zborowski

et al. 2022

ACS Chem. Neurosci.

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“…Postoperative patients in our hospital would use non-steroidal anti-inflammatory drugs combined with opioids analgesia. Opioids play an analgesic effect by simulating the physiological role of endogenous opioid peptides ( 28 ). Patients with advanced GC faced low cholesterol levels due to malnutrition.…”

Section: Discussionmentioning

confidence: 99%

Predictive Factors for Acute Postoperative Pain After Open Radical Gastrectomy for Gastric Cancer

Xie

Wei

et al. 2022

Front. Public Health

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BackgroundPain has become an important factor in evaluating patients' quality of life and clinical treatment. For gastric cancer (GC) patients, open radical gastrectomy (OG) causes significant trauma to the body, increases patients' pain after operation, and delays early recovery. The aim of this study was to investigate the predictive factors of acute pain after OG within postoperative 72 h.MethodsFrom March 2020 to September 2021, 307 patients who underwent OG were included in the study in Nanjing Drum Tower Hospital. The predictors included demographic predictors, pathological data, surgical predictors, and intraoperative predictors. The pain scores at 12, 24, 48, and 72 h after operation were evaluated by numeric rating scale (NRS). The predictors of acute pain were determined by univariate and multivariate analysis.ResultsThe average pain score (NRS) of patients showed a downward trend over time within 72 h after OG. Multivariate analysis indicated that total gastrectomy (OR 1.823, 95% CI 1.094–3.040, P < 0.05), AJCC TNM stage (II) (OR.232, 95% CI 0.062–0.872, P < 0.05), AJCC TNM stage(III) (OR.185, 95% CI 0.049–0.698, P < 0.05), BMI (kg/m2) (OR 1.75, 95% CI 1.029–2.976, P < 0.05), distant metastasis (OR 3.054, 95% CI 1.019–9.155, P < 0.05), intraoperative transfusion (OR 2.246, 95% CI 1.267–3.982, P < 0.01) were significant predictive factors for acute pain after OG.ConclusionReasonable postoperative acute pain control was the prerequisite for accelerating the postoperative rehabilitation of patients. In order to reduce the occurrence of excessive or insufficient analgesia, it was necessary for patients who underwent OG to formulate appropriate analgesics according to risk factors.

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“…Sowohl die PTBS als auch Substanzkonsumstörungen (allgemein, speziell) zeichnet eine vielfältige genetische Basis aus, die je für sich eine besondere Vulnerabilität versus Resilienz unter definierten Umwelteinflüssen epigenetisch mitbestimmt ( PTBS : [ 48 , 81 , 122 , 137 , 170 ]; Substanzkonsumstörungen allgemein : [ 11 , 23 , 64 , 71 , 189 ]; Alkohol: [ 43 ] Nikotin : [ 148 ]; Cannabis : [ 131 ]; Psychostimulantien : [ 89 , 149 ]); Opiate : [ 24 , 202 ]). Die genetische Forschung hat bisher zur Koexistenz/Komorbidität von PTBS und definierten Substanzkonsumstörungen erst einige wenige Studien vorgelegt: Für die Koexistenz von PTBS und Alkoholabhängigkeit konnte in Zwillingsstudien eine hohe genetische Überlappung nachgewiesen werden.…”

Section: Genetische Und Epigenetische Faktoren Als Gemeinsame Basis V...unclassified

Zur Komorbidität von Posttraumatischer Belastungsstörung und Sucht in biopsychosozialer Perspektive

Kapfhammer

2021

Neuropsychiatr

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ZusammenfassungPosttraumatische Belastungsstörung und Substanzkonsumstörungen treten im medizinischen Versorgungssystem häufig koexistent auf. Ihre Komorbidität geht mit schwerwiegenderen akuten klinischen Symptombildern, mit zahlreichen, oft notfallmäßigen Hospitalisierungen und geringeren Behandlungserfolgen einher. Ihre Komorbidität trägt zu dramatisch ungünstigeren Verläufen auf allen biopsychosozialen Ebenen bei. Das Thema Komorbidität von PTBS und Sucht wird auf mehreren Ebenen untersucht: in den Perspektiven von Epidemiologie, Substanzkonsumstörung als Risikofaktor für Trauma und PTBS, Trauma und PTBS als Risikofaktor für Substanzkonsumstörung, neurobiologischen Konsequenzen einer Substanzkonsumstörung für die Neurobiologie von PTBS, gemeinsam geteilten Faktoren der Genetik/Epigenetik, Persönlichkeitsdimensionen und aversiven/traumatogenen Einflüssen in der frühen Entwicklung. Der Hauptfokus der Analyse liegt auf den wechselseitig sich verstärkenden Mechanismen, die der Entwicklung und dem Verlauf beider Störungsbilder inhärent sind.

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Endogenous Opiates and Behavior: 2018

Cited by 19 publications

References 940 publications

Contribution of Opioid and Nitrergic Systems to m-Trifluoromethyl diphenyl Diselenide Attenuates Morphine-Induced Tolerance in Mice

Contribution of Opioid and Nitrergic Systems to m-Trifluoromethyl diphenyl Diselenide Attenuates Morphine-Induced Tolerance in Mice

Predictive Factors for Acute Postoperative Pain After Open Radical Gastrectomy for Gastric Cancer

Zur Komorbidität von Posttraumatischer Belastungsstörung und Sucht in biopsychosozialer Perspektive

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