Endogenous opiates and behavior: 2013

Bodnar, Richard J.

doi:10.1016/j.peptides.2014.09.013

Cited by 63 publications

(57 citation statements)

References 1,699 publications

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“…This hormone does not abolish the pain; rather, it promotes changes in perception and tolerance. The inhibition is induced by stress, and norepinephrine and β-endorphin hormones are able to inhibit nociception (Butler & Finn, 2009;Millan, 2002).…”

Section: Discussionmentioning

confidence: 99%

“…Noradrenaline is also related to endogenous analgesia, participating in pain modulation and activating the inhibition of descending pathways (Millan, ). Pain modulation by β‐endorphins occurs during exposure to acute pain or stress, and it is being studied as a biomarker of the endogenous anti‐nociceptive response (Bodnar, ; Neto, ; Rasmussen & Farr, ).…”

Section: Introductionmentioning

confidence: 99%

“…Warming the body surface to approximately 37°C is associated with adaptation to stress (Barbieri, Henrique, Chors, Maia, & Gabrielloni, 2013;Benfield et al, 2010;da Silva, de Oliveira, & Nobre, 2009;Lee, Liu, Lu, & Gau, 2013;), reduces pain and anxiety, improves uterine perfusion, modifies contractions and oxytocin release (Benfield et al, 2010), optimizes birth progress, and reduces early childbirth analgesia (Cluett & Burns, 2009). Hydrotherapy can be associated with neuroendocrine stress changes, such as the release of cortisol, catecholamines (Alehagen et al, 2005), and β-endorphins (Bodnar, 2014;Butler & Finn, 2009), which promote adaptation to stress during childbirth.…”

Section: Introductionmentioning

confidence: 99%

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Non‐pharmacological interventions during childbirth for pain relief, anxiety, and neuroendocrine stress parameters: A randomized controlled trial

Henrique

Gabrielloni

Rodney

et al. 2018

Int J of Nursing Practice

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Non‐pharmacological interventions during childbirth for pain relief, anxiety, and neuroendocrine stress parameters: A randomized controlled trial

Henrique

Gabrielloni

Rodney

et al. 2018

Int J of Nursing Practice

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“…Endogenous opiates are frequently distributed in the CNS and interplay with numerous physiologic functions such as pain regulation, respiration, immune system (Le Merrer et al 2009), and food intake (Bodnar 2014). The intracerebroventricular (ICV) injection of μ-and δ-opioid receptor agonists exerts orexigenic effects in mammals (Kaneko et al 2012).…”

Section: Doi: 1017221/2/2016-cjasmentioning

confidence: 99%

Effect of opioid receptors agonists on feeding behaviour using different diets in ad libitum fed neonatal chicken

Zendehdel¹,

Ebrahimnezhad²,

Ghalehkandi³

et al. 2017

CZECH J ANIM SCI

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Arva S., Zendehdel M., EbrahimNezhad Y., Ghiasi Ghalehkandi J., Hassanpour S., Aghdam Shahryar H. (2017): Effect of opioid receptors agonists on feeding behaviour using different diets in ad libitum fed neonatal chicken. Czech J. Anim. Sci., 62, 98-109.Despite progress in studying the role of opioids in reward, the effect of opioid receptors on feeding behaviour in ad libitum fed meat-type chicken offered different diet types is still unclear. So in this study, 12 experiments (each included 4 groups) were designed to determine the role of μ, δ, and κ receptors with different diets on feeding responses in ad libitum fed neonatal chicken. In Experiment 1, group A chicken were intracerebroventricularly (ICV) injected with saline, groups B-D chicken were ICV injected with DAMGO (µ-opioid receptor agonist; 125, 250, and 500 pmol), then standard diet without fat was offered. In Experiment 2, group A chicken were ICV injected with saline, groups B-D chicken were ICV injected with DAMGO (125, 250, and 500 pmol) and diet with nutrient energy ratio 20% below standard was provided to the birds. Experiments 3-4 were similar to Experiment 1, except after injection, diets containing nutrient energy ratio 20% above standard and standard diet with fat were provided to the birds, respectively. In Experiment 5, chicken were ICV injected with saline, DPDPE (δ-opioid receptor agonist) at doses of 20, 40, and 80 nmol, and then received standard diet without fat. Experiments 6-8 were similar to Experiment 5 in which diet containing nutrient energy ratio by 20% lower than standard, diet containing nutrient energy ratio by 20% higher than standard, and diet containing fat were provided instead of standard diet without fat to the birds, respectively. In Experiment 9, birds received ICV injection of saline and U-50488H (κ-opioid receptor agonist; 10, 20, and 40 nmol) and were provided standard diet without fat. Experiments 10-12 were similar to Experiment 9 but after ICV injection, birds were fed diet containing by 20% lower nutrient energy ratio, diet containing by 20% higher nutrient energy ratio, and standard diet containing fat, respectively. Then the cumulative food intake was measured until 180 min post injection. According to the results, DAMGO decreased while DPDPE and U-50488H increased the food intake (P < 0.05). These findings suggest endogenous governing food preferences via δ-and κ-opioid receptor in ad libitum fed neonatal chicken.

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“…These orexigenic peptides include orexin/hypocretin (OX), melanin-concentrating hormone (MCH), and enkephalin (ENK) (Barson et al, 2011, 2012b), which themselves stimulate the intake of a high-fat diet (Barson et al, 2011) as well as drugs of abuse such as alcohol (Barson et al, 2011) and are involved in abuse of nicotine (LeSage et al, 2010, Gold and Lerman, 2012, Plaza-Zabala et al, 2013) and other reinforcing substances (Bodnar, 2014, Khoo and Brown, 2014). Further studies demonstrate that these peptides are also stimulated when dietary fat is introduced early in life, even during gestation (Beck et al, 2006, Chang et al, 2008, Poon et al, 2012), and that their increase in expression, not evident in genetically obese Zucker rats (Cai et al, 2000, Beck et al, 2001) persists possibly with long-term behavioral consequences, including an increase in the intake of and dependence on these substances during adolescence (Chang et al, 2008, Barson et al, 2011, 2012b, Chang et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Prenatal fat exposure and hypothalamic PPAR β/δ: Possible relationship to increased neurogenesis of orexigenic peptide neurons

et al. 2016

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Gestational exposure to a fat-rich diet, while elevating maternal circulating fatty acids, increases in the offspring's hypothalamus and amygdala the proliferation and density of neurons that express neuropeptides known to stimulate consummatory behavior. To understand the relationship between these phenomena, this study examined in the brain of postnatal offspring (day 15) the effect of prenatal fat exposure on the transcription factor, peroxisome proliferator-activated receptor (PPAR) β/δ, which is sensitive to fatty acids, and the relationship of PPAR β/δ to the orexigenic neuropeptides, orexin, melanin-concentrating hormone, and enkephalin. Prenatal exposure to a fat-rich diet compared to low-fat chow increased the density of cells immunoreactive for PPAR β/δ in the hypothalamic paraventricular nucleus (PVN), perifornical lateral hypothalamus (PFLH), and central nucleus of the amygdala (CeA), but not the hypothalamic arcuate nucleus or basolateral amygdaloid nucleus. It also increased co-labeling of PPAR β/δ with the cell proliferation marker, BrdU, or neuronal marker, NeuN, and the triple labeling of PPAR β/δ with BrdU plus NeuN, indicating an increase in proliferation and density of new PPAR β/δ neurons. Prenatal fat exposure stimulated the double-labeling of PPAR β/δ with orexin or melanin-concentrating hormone in the PFLH and enkephalin in the PVN and CeA and also triple-labeling of PPAR β/δ with BrdU and these neuropeptides, indicating that dietary fat increases the genesis of PPAR β/δ neurons that produce these peptides. These findings demonstrate a close anatomical relationship between PPAR β/δ and the increased proliferation and density of peptide-expressing neurons in the hypothalamus and amygdala of fat-exposed offspring.

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Endogenous opiates and behavior: 2013

Cited by 63 publications

References 1,699 publications

Non‐pharmacological interventions during childbirth for pain relief, anxiety, and neuroendocrine stress parameters: A randomized controlled trial

Non‐pharmacological interventions during childbirth for pain relief, anxiety, and neuroendocrine stress parameters: A randomized controlled trial

Effect of opioid receptors agonists on feeding behaviour using different diets in ad libitum fed neonatal chicken

Prenatal fat exposure and hypothalamic PPAR β/δ: Possible relationship to increased neurogenesis of orexigenic peptide neurons

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