Endogenous opiates and behavior: 2001

Bodnar, Richard J.; Hadjimarkou, Maria M.

doi:10.1016/s0196-9781(02)00306-6

Cited by 34 publications

(3 citation statements)

References 754 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These chemicals have effects within the brain (broadly), which are almost the exact opposite of allostatic load. [65][66][67][68][69][70] It is thus arguable that if a worker's response to acute work stress and fatigue includes a progressive reduction in exercise and creative and social activities, there is a commensurate loss of important sources of personal fulfillment, which might otherwise stimulate the release of pleasure-reward neurotransmitters with their stress-reducing, allostatic load-opposing potential. This behavioral change may lead to a prolongation of work stress spillover effects in non-work time, thereby increasing the overall period of allostatic load in any 24-hour sequence.…”

mentioning

confidence: 99%

An Investigation of the Role of Non–Work-Time Behavior in Buffering the Effects of Work Strain

Winwood

Bakker

Winefield

2007

Journal of Occupational &Amp; Environmental Medicine

View full text Add to dashboard Cite

Active and fulfilling non-work-time behaviors are more significant in maximizing recovery from work strain than is commonly recognized. This effect is arguably due to the downregulation of stress-induced brain arousal, and stimulation of the pleasure-reward brain neurophysiology. Consistent recovery from work strain between work periods may represent a crucial factor in avoiding work-related "loss spirals" leading to maladaptive health outcomes, which can be particularly relevant to workers in inherently stressful occupations.

show abstract

mentioning

confidence: 99%

An Investigation of the Role of Non–Work-Time Behavior in Buffering the Effects of Work Strain

Winwood

Bakker

Winefield

2007

Journal of Occupational &Amp; Environmental Medicine

View full text Add to dashboard Cite

show abstract

“…Endogenous opioid peptides participate in the regulation of reproductive functions at multiple sites (Fabbri et al, 1985; Bodnar and Hadjimarkou, 2002). However, it is presently unclear whether and how these peptides exert a direct effect on the function of sperm cells.…”

mentioning

confidence: 99%

Enkephalin‐Degrading Enzymes in Normal and Subfertile Human Semen

Irazusta

Valdivia

et al. 2004

Journal of Andrology

View full text Add to dashboard Cite

Opioid peptides have been reported to have important functions in human reproduction. Indeed, very high concentrations of enkephalins and their degrading enzymes have been reported in human semen. In the present paper, we compare the activity of two enkephalin-degrading enzymes, aminopeptidase N and neutral endopeptidase 24.11, in different fractions of semen from normozoospermic, fertile men and from subfertile patients with different abnormalities revealed by spermiogram analysis (asthenozoospermia, necrozoospermia, and teratozoospermia). High levels of activity of aminopeptidase N were found in the soluble and particulate sperm fractions of semen from patients presenting asthenozoospermia with necrozoospermia. In contrast, lower aminopeptidase N activity was measured in the soluble sperm fraction of asthenozoospermic semen. The percentage of dead spermatozoa was positively correlated with aminopeptidase N activity in both soluble and particulate sperm fractions. In contrast, the percentage of immobile spermatozoa was negatively correlated with aminopeptidase activity in soluble and particulate sperm, and in prostasome fractions. Levels of activity of neutral endopeptidase were found to be unaltered among the different conditions. In summary, the results of the present study indicate that alterations in the activity of aminopeptidase N may be one of the molecular components that contribute to male human subfertility.

show abstract

“…Mercer and Holder [75] also implicitly advocate consideration of the search problem with their emphasis of the role of the endogenous opioids in food cravings. 47 For a review of these findings, see Bodnar [15], p. 2324.…”

Section: Foreseeing Addictionmentioning

confidence: 99%

A theory of natural addiction

Smith

Tasnádi

2007

Games and Economic Behavior

View full text Add to dashboard Cite

Economic theories of rational addiction aim to describe consumer behavior in the presence of habit-forming goods. We provide a biological foundation for this body of work by formally specifying conditions under which it is optimal to form a habit. We demonstrate the empirical validity of our thesis with an in-depth review and synthesis of the biomedical literature concerning the action of opiates in the mammalian brain and their effects on behavior. Our results lend credence to many of the unconventional behavioral assumptions employed by theories of rational addiction, including adjacent complementarity and the importance of cues, attention, and self-control in determining the behavior of addicts. Our approach suggests, however, that addiction is "harmful" only when the addict fails to implement the optimal solution. We offer evidence for the special case of the opiates that harmful addiction is the manifestation of a mismatch between behavioral algorithms encoded in the human genome and the expanded menu of choices-generated for example, by advances in drug delivery technology-faced by consumers in the modern world.

show abstract

Endogenous opiates and behavior: 2001

Cited by 34 publications

References 754 publications

An Investigation of the Role of Non–Work-Time Behavior in Buffering the Effects of Work Strain

An Investigation of the Role of Non–Work-Time Behavior in Buffering the Effects of Work Strain

Enkephalin‐Degrading Enzymes in Normal and Subfertile Human Semen

A theory of natural addiction

Contact Info

Product

Resources

About