Endogenous oncornaviral gene expression in adult and fetal mice: quantitative, histologic, and physiologic studies of the major viral glycorprotein, gp70.

Lerner, Richard A.; Wilson, Curtis B.; Villano, Bert C. Del; McConahey, Patricia J.; Dixon, Frank J.

doi:10.1084/jem.143.1.151

Cited by 187 publications

(69 citation statements)

References 29 publications

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“…Expression of genes of the xenotropic viruses seems to occur in differentiating cells. The viral glycoprotein gp70 has been found in differentiating thymocytes (36,37), in the male genital tract, and in sperm (38). Hematopoietic cells (39), embryos and placenta (40), as well as regenerating liver cells (41) probably express these viruses or part of their genes.…”

Section: Discussionmentioning

confidence: 99%

Genetic studies of autoimmunity and retrovirus expression in crosses of New Zealand black mice I. Xenotropic virus.

Datta

Manny

Andrzejewski

et al. 1978

The Journal of Experimental Medicine

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Type C RNA viruses (retroviruses) have been implicated in the autoimmune disease of New Zealand Black (NZB) 1 mice (1, 2). However, the evidence for this is only circumstantial because the retroviruses isolated from NZB mice are xenotropic in host range; this prohibits a direct test of their pathogenicity in mice by, for example, inoculation of filtrates (3, 4). Nevertheless, the relationship between autoimmunization and xenotropic viruses c&n be ascertained by genetic tests because the genes of these agents are an integral part of cellular chromosomes (5) and their expression in NZB mice is governed by two autosomal dominant genes (6, 7). In this paper we describe results of genetic experiments designed to test the hypothesis that expression of xenotropic virus is required for the development of autoimmune disease. The following paper (8) deals with the relationship between autoimmune disease in NZB mice and expression of the major envelope glycoprotein of the virus, gp70. Materials and MethodsMice. NZB, SWR, C57BL/6, B10.A, and AKR mice were obtained from The Jackson Laboratory, Bar Harbor, Maine. Reciprocal crosses were made to produce FI and backcross progeny mice. Because the maternal direction of the cross did not affect the results, all data for a given cross were pooled and presented by a single nomenclature: F~ for (SWR × NZB)F~; (F~ × SWR) for backcross to SWR, and (F~ x NZB) for backcross to NZB. The mice were 11-24 mo old when tested.Retrovirus Assays XI~.NOTROPIC VIRUS. Spleen cell suspensions were prepared and serially diluted as described previously (6, 7, 9). They were assayed by cocultivation on monolayers of the feline 81 cell line

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Section: Discussionmentioning

confidence: 99%

Genetic studies of autoimmunity and retrovirus expression in crosses of New Zealand black mice I. Xenotropic virus.

Datta

Manny

Andrzejewski

et al. 1978

The Journal of Experimental Medicine

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“…Presently there is no evidence that the lymphocyte membrane antigen(s) detected with the extensively absorbed anti-SLE antisera described here have any relationship to virus or cell surface determinants related to any viral genome (37)(38)(39)(40). Considerably more work will be necessary before such a possibility can be resolved.…”

Section: Resultsmentioning

confidence: 94%

Lymphocyte antigens in systemic lupus erythematosus: studies with heterologous antisera.

Williams¹,

Hughes²,

Snaith³

et al. 1980

J. Clin. Invest.

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“…No digestion of gp70, as determined by measuring the size of gp70 by sucrose density gradient analysis, was found in vitro after 1,2, and 3 hours of incubation at 37°C. In addition, the clearance rate of gp70 from tissue cage fluids 6.5 hours), which was determined following the injection of serum gp70 into the tissue cage, was comparable with the clearance rate of gp70 from sera (T1/2 5.5 hours) (20). We tested other biologic fluids for gp70 levels to exclude a peculiarity of our tissue cage model.…”

Section: Resultsmentioning

confidence: 99%

“…First, tissue cage fluids did not exhibit significant proteolytic activities for gp70. Second, kinetrics studies have shown that the disappearance rate of gp70 injected into tissue cages was not significantly different from its clearance rate in sera (20).…”

Section: -mentioning

confidence: 99%

Quantitation of retroviral gp70 antigen, autoantibodies, and immune complexes in extravascular space in arthritic mrl‐lpr/lpr mice. use of a subcutaneously implanted tissue cage model

Dayer

Yoshida

Izui

et al. 1987

Arthritis & Rheumatism

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MRL‐lpr/lpr (MRL/1) mice spontaneously develop a disease that is characterized by glomerulonephritis, diffuse vasculitis, and arthritis associated with high levels of autoantibodies that include IgG rheumatoid factor (RF). To define the immunopathogenic mechanisms that lead to the development of extravascular lesions such as arthritis, we implanted a tissue cage subcutaneously in arthritic MRL/1 mice and compared components of the tissue cage fluid, which resembles the extravascular fluid, with those of sera. When compared with those of sera, tissue cage fluids from arthritic MRL/1 mice had similar levels of RF and one‐third the amount of Clq immune complexes. In contrast, anti‐DNA activities in tissue cage fluids corresponded to only 10% of the serum activities and, most strikingly, nephritogenic retroviral gp70‐anti‐gp70 immune complexes were almost undetectable in tissue cage fluids. This was also the case for another strain of autoimmune mice, (New Zealand black x New Zealand white)F1 mice, although they did not produce RF. The absence of gp70 immune complexes in tissue cage fluids could be due to markedly limited diffusion of gp70 antigen in these fluids. These results strongly suggest that serum proteins, including autoantigen and autoantibodies, appear in extravascular fluid in a selective manner, depending on their size and charge. Their specific properties in sera or extravascular fluid could partly account for the different manifestations of vascular and extravascular lesions observed in autoimmune mice.

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Endogenous oncornaviral gene expression in adult and fetal mice: quantitative, histologic, and physiologic studies of the major viral glycorprotein, gp70.

Cited by 187 publications

References 29 publications

Genetic studies of autoimmunity and retrovirus expression in crosses of New Zealand black mice I. Xenotropic virus.

Genetic studies of autoimmunity and retrovirus expression in crosses of New Zealand black mice I. Xenotropic virus.

Lymphocyte antigens in systemic lupus erythematosus: studies with heterologous antisera.

Quantitation of retroviral gp70 antigen, autoantibodies, and immune complexes in extravascular space in arthritic mrl‐lpr/lpr mice. use of a subcutaneously implanted tissue cage model

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