Endogenous Nociceptin System Involvement in Stress Responses and Anxiety Behavior

Fulford, Allison

doi:10.1016/bs.vh.2014.12.012

Cited by 7 publications

(3 citation statements)

References 181 publications

(230 reference statements)

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“…Although not entirely consistent, the present results and the findings of Chae et al (2013) confirm that mechanical stimulation caused by the therapeutic tool during needling activates sensorimotor network, which is caused by acupuncture itself. Consistent with previous studies ( Hui et al, 2000 ), this study also found evidence that acupuncture at Hegu triggers extensive deactivation of the cerebral cortex, including the anterior cingulate cortex (ACC) and superior temporal gyrus that overlap with the limbic system ( Catani et al, 2013 ; Fulford, 2015 ). Furthermore, the limbic system has been shown to play an important role in the acupuncture effects of multiple acupoints ( Fang et al, 2009 ).…”

Section: Discussionsupporting

confidence: 91%

Activation likelihood estimation identifies brain regions activated during puncturing at Hegu in healthy volunteers: A meta-analysis

et al. 2022

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BackgroundHegu is the most commonly used acupoints for pain relief. Recently, several functional neuroimaging studies have been performed on acupuncture at Hegu in healthy volunteers, but these studies have yielded diverse findings. Therefore, there is an urgent need to understand the brain response characteristics of acupuncture at Hegu.MethodsNeuroimaging studies on acupuncture at Hegu published before October 2022 were collected from PubMed, Web of Science, Google Scholar, Embase, and CNKI (China National Knowledge Infrastructure) databases, and were screened by strict inclusion and exclusion criteria. The extraction of brain coordinates was performed by two independent researchers, and the results were analyzed using activation likelihood estimation (ALE) analysis based on quantitative coordinates.ResultsIn total, 338 studies were searched, of which 19 studies were included in the final analysis after a rigorous double-blind screening review. Activation likelihood estimation showed that postcentral gyrus in the left brain were activated, whereas the anterior cingulate in the left brain and superior temporal gyrus in the right brain were deactivated.ConclusionAcupuncture at Hegu in healthy volunteers did not reveal specific brain regions. This finding implies that organismal status of the study subjects may have an important impact on the effect of acupoints.Systematic review registration[https://www.crd.york.ac.uk], identifier [CRD42020197296].

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Section: Discussionsupporting

confidence: 91%

Activation likelihood estimation identifies brain regions activated during puncturing at Hegu in healthy volunteers: A meta-analysis

et al. 2022

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“…The neurons producing the precursor have a slightly more restricted distribution (Reinscheid et al 2000), with strong expression in the BNST, the medial pre-optic area, the lateral septum and the medial and central amygdala (CeA). This distribution strongly suggests a role of the N/OFQ system at the interface between the control of stress and emotions (Fulford 2015;Gavioli and Calo 2013;Witkin et al 2014) and memory processes (Andero 2015;Noda et al 2000;Ouagazzal 2015) that are the main focus of this review article.…”

Section: Introductionmentioning

confidence: 90%

The Nociceptin/Orphanin FQ System and the Regulation of Memory

Moulédous

2018

Handbook of Experimental Pharmacology

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Nociceptin/Orphanin FQ (N/OFQ) is an endogenous neuropeptide of 17 amino acids, related to opioid peptides but with its own receptor, distinct from conventional opioid receptors, the ORL1 or NOP receptor. The NOP receptor is a G protein-coupled receptor which activates Gi/o proteins and thus induces an inhibition of neuronal activity. The peptide and its receptor are widely expressed in the central nervous system with a high density of receptors in regions involved in learning and memory. This review describes the consequences of the pharmacological manipulation of the N/OFQ system by NOP receptor ligands on learning processes and on the consolidation of various types of long term memory. We also discuss the role of endogenous N/OFQ release in the modulation of learning and memory. Finally we propose several putative neuronal mechanisms taking place at the level of the hippocampus and amygdala and possibly underlying the behavioral amnestic or promnesic effects of NOP ligands.

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“…Many studies have confirmed that depression is relevant to dynorphin [37][38][39], but few studies supported the relationship between anxiety and dynorphin and some researchers even found genetic inactivation of κ Opioid Receptor (KOR)-Dynorphin signaling resulted in increased anxiety-like behavior [40]. Anxiety may also act on NERD through other opioid-related peptide like nociceptin/orphanin FQ (N/OFQ) rather than dynorphin [41].…”

Section: Discussionmentioning

confidence: 99%

Dynorphin participates in interaction between depression and non-erosive reflux disease

et al. 2022

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Background To explore the relationships between anxiety/depression and NERD, we focused on dynorphin (Dyn), an important member of visceral hypersensitivity, and its related pathways. Methods Pearson’s correlation analysis on patients with NERD and in vivo experiment on NERD rat model. Part 1: Pearson’s correlation analysis among serum levels of Dyn, clinical symptoms and HADS scores of NERD patients were carried on. Part 2: Wistar rats were randomly divided into 2 groups: control group and model group. The data of pH value, immobility time, serum Dyn concentration, NMDAR1 and SP expression were, respectively, derived from automatic pH recorder, tail suspension test, enzyme-linked immunosorbent assay, immunohistochemistry and immunofluorescence. Results Part 1: Pearson’s correlation analysis showed that there was a linear correlation between Clinical Symptom (CS) score and HADS score (HAD-A, HAD-D), and the correlation coefficients were 0.385 and 0.273 respectively; the correlation coefficient between lg (Dyn) and lg (CS score) was r = 0.441, P = 0.002; the correlation coefficient between lg(Dyn) and lg (HAD-D score) was r = 0.447, P = 0.002. Part 2: The pH value of the lower esophagus in the model group was lower than that in the control group (P < 0.01). The tail suspension immobility time of model group was significantly longer than that of control group (P < 0.01). The serum Dyn concentration and the expression level of NMDAR1 in spinal cord and SP in lower esophageal mucosa of model group were significantly higher than those of control group (P < 0.05). Conclusion Increased serum dynorphin level may be a sign of correlation between depression and NERD.

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Endogenous Nociceptin System Involvement in Stress Responses and Anxiety Behavior

Cited by 7 publications

References 181 publications

Activation likelihood estimation identifies brain regions activated during puncturing at Hegu in healthy volunteers: A meta-analysis

Activation likelihood estimation identifies brain regions activated during puncturing at Hegu in healthy volunteers: A meta-analysis

The Nociceptin/Orphanin FQ System and the Regulation of Memory

Dynorphin participates in interaction between depression and non-erosive reflux disease

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