Endogenous Nitric Oxide in the Nasal Airways of Healthy Term Newborn Infants in Taiwan

Chang, Chia-Wei; Liu, Tao-Yuan; Hua, Yi-Ming; Lee, Chuen-Ming; Yuh, Yeong‐Seng

doi:10.1016/s1875-9572(09)60003-6

Cited by 4 publications

(13 citation statements)

References 23 publications

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“…Compared to the large number of nNO studies in school‐aged children and adolescents, the literature on nNO measurement in young children is less extensive. Several studies demonstrated that nNO measurement can be obtained from uncooperative children during tidal breathing with nasal aspiration technique . In this case, the child is seated either on a chair, or on parent's knees.…”

Section: Introductionmentioning

confidence: 99%

“…Table summarizes individual and environmental factors that may affect nNO values . Compared to velum closure techniques, tidal breathing results in significantly reduced nNO levels . In a study of preschool Italian children, Piacentini and colleagues reported that nNO was significantly lower in uncooperative subjects aging less than 12 months than in cooperative school‐aged children, with some values overlapping those reported in PCD .…”

Section: Introductionmentioning

confidence: 99%

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Clinical application of nasal nitric oxide measurement in pediatric airway diseases

Manna

Montella

Maniscalco³

et al. 2014

Pediatric Pulmonology

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Nitric oxide plays an important role in several physiological and pathophysiological processes in the respiratory tract. Different ways to measure nasal nitric oxide levels in children are currently available. The possibility of obtaining nasal nitric oxide measurement from relatively young children, combined with the availability of portable devices that can be used even in the office setting, opens new perspectives for nasal nitric oxide analysis in the pediatric daily practice. This review presents a synopsis about the current clinical applications of nasal nitric oxide measurement in the pediatric clinical practice. A total of 3,775 articles on the topic were identified, of which 883 duplicates were removed, and 2,803 were excluded based on review of titles and abstracts. Eighty-nine full text articles were assessed for eligibility and 32 additional articles were obtained from the reference lists of the retrieved studies. Since very low nasal nitric oxide levels are found in the majority of patients with primary ciliary dyskinesia, most publications support a central role for nasal nitric oxide to screen the disease, and indicate that it is a very helpful first-line tool in the real-life work-up in all age groups. Decreased nasal nitric oxide concentration is also typical of cystic fibrosis, even though nasal nitric oxide is not as low as in primary ciliary dyskinesia. In other upper airway disorders such as allergic rhinitis, rhinosinusitis, nasal polyposis, and adenoidal hypertrophy, clinical utility of nasal nitric oxide is still critically questioned and remains to be established. Since nNO determination is flow dependent, a general consensus from the major investigators in this area is highly desirable so that future studies will be performed with the same flow rate. A shared nNO methodology will enable to overcome the challenges that lie ahead in incorporating nNO measurement into the mainstream clinical setting of pediatric airway diseases.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical application of nasal nitric oxide measurement in pediatric airway diseases

Manna

Montella

Maniscalco³

et al. 2014

Pediatric Pulmonology

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“…Most studies have been cross‐sectional; a few examined repeated measures during the first days or week; only three studies performed longitudinal eNO measurements during the first month of life comparing neonates with and without CLD/BPD. The studies were either small ( n = 15‐24) or the numbers of neonates measured on each Day varied between 0% and 100% ( n = 80) …”

Section: Discussionmentioning

confidence: 99%

“…It includes off‐line or online measurements, adapted for research by counting and removing irregular breaths; hence, not applicable in a daily clinical setting. Measurements of eNO in premature mechanically ventilated neonates have been performed in the tube as well as in spontaneously breathing infants with a nasal prong or a facemask . The method widely used is counting 100 breaths and excluding sighs and apneas.…”

Section: Discussionmentioning

confidence: 99%

Tidal breath eNO measurements in a cohort of unsedated hospitalized neonates—A method validation

Schmidt

Reim

Jensen

et al. 2018

Pediatric Pulmonology

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“…NO concentration in exhaled air is highly air flow-dependent and originates primarily in the nose and the paranasal sinuses, with some also originating in the lower part of the respiratory tract [21,22]. Therefore, in adults and older children the measurement conditions have been standardized [23].…”

Section: Introductionmentioning

confidence: 99%

Effect of intubation and mechanical ventilation on exhaled nitric oxide in preterm infants with and without bronchopulmonary dysplasia measured at a median postmenstrual age of 49 weeks

et al. 2014

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BackgroundExhaled nitric oxide (eNO) is a marker of established airway inflammation in adults and children, but conflicting results have been reported in preterm infants when postnatal eNO is measured during tidal breathing. This study investigated the extent to which intubation and mechanical ventilation (MV) affect eNO and NO production (V’NO) in preterm infants with and without bronchopulmonary dysplasia (BPD).Patients and methodsA total of 176 very low birth weight (VLBW) infants (birth weight <1500 g), including 74 (42%) with and 102 (58%) without BPD, were examined at a median postmenstrual age of 49 weeks. Of the 176 infants, 84 (48%) did not require MV, 47 (27%) required MV for <7 days and 45 (26%) required MV for ≥7 days. Exhaled NO and tidal breathing parameters were measured in sleeping infants during tidal breathing, respiratory mechanics were assessed by occlusion tests, and arterialized capillary blood gas was analyzed.ResultseNO was significantly correlated with tidal breathing parameters, while V’NO was correlated with growth parameters, including age and body length (p < 0.001 each). Infants who were intubated and received MV for <7 days had significantly lower eNO (p < 0.01) and V’NO (p < 0.01) than non-ventilated infants. In contrast, eNO and V’NO did not differ significantly in non-ventilated infants and those receiving MV for ≥7 days. Multivariate analysis showed that independent on the duration of MV eNO (p = 0.003) and V’NO (p = 0.018) were significantly increased in BPD infants comparable with the effects of intubation and MV on eNO (p = 0.002) and V’NO (p = 0.017).ConclusionsPreterm infants with BPD show only weak postnatal increases in eNO and V’NO, but these changes may be obscured by the distinct influences of breathing pattern and invasive respiratory support. This limits the diagnostic value of postnatal eNO measurements in the follow-up of BPD infants.

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Endogenous Nitric Oxide in the Nasal Airways of Healthy Term Newborn Infants in Taiwan

Abstract: We conclude that nasal NO increased significantly in the first 3 days of life.

Cited by 4 publications

References 23 publications

Clinical application of nasal nitric oxide measurement in pediatric airway diseases

Clinical application of nasal nitric oxide measurement in pediatric airway diseases

Tidal breath eNO measurements in a cohort of unsedated hospitalized neonates—A method validation

Effect of intubation and mechanical ventilation on exhaled nitric oxide in preterm infants with and without bronchopulmonary dysplasia measured at a median postmenstrual age of 49 weeks

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