Endogenous Nitric Oxide Generation Linked to Ryanodine Receptors Activates Cyclic GMP / Protein Kinase G Pathway for Cell Proliferation of Neural Stem/Progenitor Cells Derived From Embryonic Hippocampus

In Vivo and In Vitro Treatment With Edaravone Promotes Proliferation of Neural Progenitor Cells Generated Following Neuronal Loss in the Mouse Dentate Gyrus

“…In particular, a recent report provided direct evidence to confirm that edaravone promotes nitric oxide synthesis/ release following acute endothelial damage in peripheral microvessels, thus indicating it to have a beneficial effect on some neurodegenerative disorders (35). In addition, previous reports of ours indicated that endogenous or exogenous nitric oxide promotes the proliferation of NPCs derived from the embryonic mouse hippocampus (28,36) as well as from the dentate gyrus of the adult mouse (data not shown). Hence, the possibility that the promoting effect of edaravone on NPC proliferation was due to enhanced nitric oxide synthesis/release is feasible.…”

L-N-Iminoethyl-lysine after experimental brain trauma attenuates cellular proliferation and astrocyte differentiation

“…NO activates the NO/cGMP/PKG pathway, which has a possible role in survival support in many cells [1,15,16]. In particular, NO appears to promote neuro stem/progenitor cell survival and differentiation [6,7,37,38].…”

Possible Involvement of Caspases in Proliferation of Neocortical Neural Stem/Progenitor Cells in the Developing Mouse Brain

“…[6][7][8] In brief, the neocortex dissected from the fetal Std-ddY mouse, after which its cells were dissociated in 0.02% (w/v) ethylenediaminetetraacetic acid (EDTA) at room temperature for 12 min. The cells were then washed twice with Dulbecco's modified Eagle's medium (DMEM)/F12 supplemented with 10% (v/v) fetal bovine serum and subsequently once with DMEM/F12 containing 0.6% (w/v) glucose, 15 mM sodium bicarbonate, 20 nM progesterone, 30 nM sodium selenite, 60 nM putrescine, and 100 µg/mL apo-transferrin.…”