Endogenous Levels of Circulating Androgens Are Not Associated with Risk of Microscopic Colitis

Tracy, Michaela; Challa, Prasanna K.; Canha, Lauren; Burke, Kristin E.; Ananthakrishnan, Ashwin N.; Lopes, Emily W.; Richter, James M.; Chan, Andrew T.; Khalili, Hamed

doi:10.1007/s10620-022-07678-3

Cited by 1 publication

(1 citation statement)

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“…T plays a regulatory role in female menopause and pregnancy (1,4). T can be converted into estradiol under the catalysis of aromatase (5). Abnormal expression of T may lead to infertility (6,7).…”

Section: Introductionmentioning

confidence: 99%

A meta-analysis: Effect of androgens on reproduction in sows

Guo

Liu

et al. 2023

Front. Endocrinol.

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IntroductionThe mechanisms by which male hormones affect the development of ovaries and follicles has been studied by injecting exogenous androgens into sows. This may provide a reference for human polycystic ovary syndrome (PCOS), and can also provide guidance for improving the litter size of sows.MethodsWe present a meta-analysis of studies published in the past 30 years on the effect of androgens on the ovulation rate of sows. A total of 517 papers were analyzed.ResultsThe results showed that both testosterone (T) and dihydrotestosterone (DHT) injected into sows were positively related to the ovulation rate. T did not have a relevant effect on swine in vivo blastocyst survival rate. DHT had a negative phase with respect to blastocyst survival rate. Pig T-androgen receiver affinity was higher than the analogous affinity for DHT; this is different in humans. This suggests that sows are not suitable as human PCOS experimental animal models.DiscussionTo improve the litter size of sows, future research should focus on the mixed use of T and DHT, and the timing of use should be consistent with the periodic changes in androgen levels in sows. In addition, the welfare of experimental sows should be considered with reference to the clinical symptoms of PCOS.

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