Endogenous hydrogen sulphide mediates the cardioprotection induced by ischemic postconditioning

Abstract

Yong QC, Lee SW, Foo CS, Neo KL, Chen X, Bian JS. Endogenous hydrogen sulphide mediates the cardioprotection induced by ischemic postconditioning.

Cardioprotective Pathways During Reperfusion: Focus on Redox Signaling and Other Modalities of Cell Signaling

“…Importantly, both endogenous and exogenous H 2 S induce PostC-like cardioprotection, involving the Akt-eNOS-PKC pathway. Moreover, the PKC inhibitor chelerythrine and the K ATP channel blockers, glibenclamide or 5-hydroxydecanoate, are able to reverse the cardioprotective effects of the H 2 S-donor, NaHS (89,203). While it is not clear whether and=or how H 2 S modifies the activity of RISK=SAFE enzymes involved in PostC, it seems that H 2 S directly alters the activity of K ATP channels.…”

Hydrogen Sulfide Regulates Na+/H+ Exchanger Activity via Stimulation of Phosphoinositide 3-Kinase/Akt and Protein Kinase G Pathways

“…Together with other groups, we have found that both endogenous and exogenous H 2 S protect the heart from isoproterenol-induced myocardial injury by directly scavenging oxygen free radicals (Geng et al, 2004a) and inhibiting the adenylyl cyclase/ cAMP pathway or L-type calcium channel (Yong et al, 2008b). Moreover, researchers have found that preconditioning and postconditioning with H 2 S produced cardioprotective effects against ischemic injury via the regulation of protein kinase C, K ATP channels, cyclooxygenase-2, NO, p42/44-mitogen-activated protein kinase, phosphoinositol-3-kinase (PI3K)/Akt, and GSK3␤ pathways Yong et al, 2008a;Yao et al, 2010). More importantly, endogenous H 2 S was found to contribute to the cardioprotection induced by ischemic preconditioning and postconditioning Pan et al, 2006;Yong et al, 2008a).…”

“…Moreover, researchers have found that preconditioning and postconditioning with H 2 S produced cardioprotective effects against ischemic injury via the regulation of protein kinase C, K ATP channels, cyclooxygenase-2, NO, p42/44-mitogen-activated protein kinase, phosphoinositol-3-kinase (PI3K)/Akt, and GSK3␤ pathways Yong et al, 2008a;Yao et al, 2010). More importantly, endogenous H 2 S was found to contribute to the cardioprotection induced by ischemic preconditioning and postconditioning Pan et al, 2006;Yong et al, 2008a). In addition, H 2 S may produce a proangiogenic effect (Cai et al, 2007) that can contribute to its cardioprotective action.…”

Pharmacological postconditioning against myocardial infarction with a slow-releasing hydrogen sulfide donor, GYY4137

“…there may be reduced H 2 S production (Yong et al, 2008, Han et al, 2015, Islam et 109 al., 2015. The administration of exogenous H 2 S donor compounds or increasing 110 endogenous production of H 2 S has been well documented to reduce ischemia-…”