Endogenous growth factors as cosmeceuticals

Mehta, Rahul; Fitzpatrick, Richard

doi:10.1111/j.1529-8019.2007.00149.x

Cited by 62 publications

(53 citation statements)

References 63 publications

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“…Growth factors play an important role in reversing the effects of skin aging mediated both by chronological and environmental factors [1]. Active substances such as exogenous growth factors may be used as a strategy to attenuate the signs of aging.…”

Section: Discussionmentioning

confidence: 99%

“…There are some studies reporting that growth factors are a potent antioxidants that inhibits the aging of skin cells, strengthens its defense processes and reduces wrinkles [1]. Some study reports that growth factors are critical for the proliferation of skin cells like keratinocytes and fibroblasts.…”

Section: Efficacy Of Rfgf-1 On Human Skin Cellsmentioning

confidence: 99%

“…On the other hand, it has been suggested that growth factors and cytokines can penetrate through hair follicles, sweat glands or compromised skin, followed by interaction with cells in the epidermis, such as keratinocytes, to produce signaling cytokines that affect cells deeper in the dermis, such as fibroblasts [1].…”

Section: Penetration Through the Skin Barriermentioning

confidence: 99%

“…During the aging process, the proliferative and metabolic activity of fibroblasts decreases, the fibers' functions are impaired and their structure becomes modified and then destroyed. Some of the biochemical effects of intrinsic and extrinsic skin aging are similar to the formation of a wound [1]. Human growth factors (HGF) play the key role in wound healing and they are important for proper cell functionality [2].…”

Section: Introductionmentioning

confidence: 99%

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A study of the activity and effectiveness of recombinant fibroblast growth factor (Q40P/S47I/H93G rFGF-1) in anti-aging treatment

Żerańska¹,

Pasikowska²,

Szczepanik³

et al. 2016

pdia

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A b s t r a c tIntroduction: Fibroblast growth factor 1 (FGF-1) is a powerful mitogen involved in the stimulation of DNA synthesis and the proliferation of a wide variety of cell types. Fibroblast growth factor 1 was genetically modified to improve its thermal stability and resistance to protease degradation without losing its biological activity. Aim: To study the impact of Q40P/S47I/H93G rFGF-1 on skin cells, its penetration through the skin and the evaluation of the rFGF-1-cosmetic product properties. Material and methods:In vitro studies included the examination of primary fibroblast and keratinocyte viability after the incubation with rFGF-1. The penetration abilities of rFGF-1 in various formulations and carrier systems were examined ex vivo by the Raman spectroscopy. In vivo studies -HF Ultrasound and 3D Imaging System -were used to evaluate the anti-aging properties of creams containing rFGF-1. Results:In vitro studies demonstrated that rFGF-1 strongly enhanced the viability of the treated cells. The Raman Spectroscopy analysis indicated that rFGF-1 encapsulated in lipid spheres penetrate through the stratum corneum to the depth of 60 µm, and added to the o/w formulation -could penetrate to a depth of 90 µm. The results obtained from Primos revealed the reduction of the volume and the depth of the wrinkles. Changes in the skin structure in the analyzed areas were evaluated by HF Ultrasonography. Conclusions: Recombinant FGF-1 strongly stimulated fibroblast and keratinocyte proliferation. However, the transition of this protein through the SC required an appropriate carrier system -lipid spheres. All tests -in vitro, ex vivo and in vivo -have proved that rFGF-1 is a substance with a potentially wide spectrum of use.

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Section: Discussionmentioning

confidence: 99%

Section: Efficacy Of Rfgf-1 On Human Skin Cellsmentioning

confidence: 99%

Section: Penetration Through the Skin Barriermentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A study of the activity and effectiveness of recombinant fibroblast growth factor (Q40P/S47I/H93G rFGF-1) in anti-aging treatment

Żerańska¹,

Pasikowska²,

Szczepanik³

et al. 2016

pdia

View full text Add to dashboard Cite

show abstract

“…Growth factors promote collagen synthesis, thus potentially benefit in rejuvenation [13] [14] [15]. Human growth factors are emerging as potential anti-aging agents [16] [17] [18].…”

Section: Discussionmentioning

confidence: 99%

A Single Arm, Monocentric, Prospective, Open Label Study to Evaluate Anti-Ageing Efficacy of Human Growth Factors and Cytokines Containing Cosmetic Skin Serum in Indian Female Population

Sachdev

Chullikana²,

Seetharam³

et al. 2017

JCDSA

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Introduction: The use of growth factors and cytokines in skin rejuvenation and reversal of photo ageing is a novel anti-ageing treatment. These factors provide a microenvironment that seems to favor tissue repair and regeneration. Methods: An open label, monocentric, single arm study to evaluate anti-ageing efficacy of conditioned medium obtained from adult human bonemarrow derived allogenic mesenchymal stromal cells (BMMSC) along with excipients formulated into a cosmetic serum, was conducted in 40 Indian female population aged 35 to 60 years, belonging to skin type IV -VI of Norwood Scale for a duration of 90 days. Parameters-fine lines, wrinkles, crow's feet, evenness of skin tone, skin firmness/laxity, hydration of skin, homogeneity of age spots, and visible pores were used to evaluate the anti-ageing and rejuvenating properties of the test product. Results and Discussion: Improvement was seen in majority of parameters starting from 15 -30 days. Product was safe and well tolerated as per the dermatologist and subjects' self-assessment.

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Growth Factors in Cosmeceuticals

Fabi

Sundaram²

2013

Cosmeceuticals and Cosmetic Practice

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Endogenous growth factors as cosmeceuticals

Cited by 62 publications

References 63 publications

A study of the activity and effectiveness of recombinant fibroblast growth factor (Q40P/S47I/H93G rFGF-1) in anti-aging treatment

A study of the activity and effectiveness of recombinant fibroblast growth factor (Q40P/S47I/H93G rFGF-1) in anti-aging treatment

A Single Arm, Monocentric, Prospective, Open Label Study to Evaluate Anti-Ageing Efficacy of Human Growth Factors and Cytokines Containing Cosmetic Skin Serum in Indian Female Population

Growth Factors in Cosmeceuticals

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