Endogenous GABA Does Not Mediate the Inhibitory Effects of Gabapentin on Spinal Reflexes in Rats

Shimizu, Shinobu; Honda, Motoko; Tanabe, Mitsuo; Oka, Jun-Ichiro; Ono, Hideki

doi:10.1254/jphs.94.137

Cited by 3 publications

(4 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our previous study indicated that systemically administered gabapentin decreases the amplitude of both the MSR and PSR at the spinal level (8). The present study further showed that the effect of gabapentin applied directly to the ventral horn largely mimics the effect on the spinal reflex of systemically applied gabapentin and can represent the antispastic action and/ or the side effects associated with motor incoordination.…”

Section: Discussionsupporting

confidence: 77%

“…Such increase in the GABAergic system in the spinal dorsal and ventral horn could lead to analgesic effects and reduction in motor output, respectively. In our recent study, however, decreases of the spinal reflexes in spinalized rats did not involve either GABA A receptors or, presumably, endogenous GABA (8). In the study presented here, we investigated further the possible involvement of GABA B receptors in this effect using a typical GABA B -receptor agonist baclofen, which is widely used for the treatment of spasticity, and the specific GABA B receptor antagonist (3-aminopropyl)(diethoxymethyl)phosphinic acid (CGP35348).…”

Section: Introductioncontrasting

confidence: 49%

“…Gabapentin elicits ataxia clinically in about 10% of patients (5,6) and experimentally in rodents (7). We have previously demonstrated that gabapentin decreases the spinal reflexes in rats (8). A reduction in motor output by gabapentin can explain some aspects of the antispastic property and / or the side effect associated with motor incoordination.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

GABAB Receptors Do Not Mediate the Inhibitory Actions of Gabapentin on the Spinal Reflex in Rats

et al. 2004

Self Cite

View full text Add to dashboard Cite

Abstract. The clinical effectiveness of gabapentin for the treatment of epilepsy, spasticity, and neuropathic pain has been established. The mechanisms responsible for those actions, however, are still not clearly understood. We have recently demonstrated that gabapentin reduces the spinal reflex in rats via mechanisms that do not involve g-aminobutyric acid (GABA) A receptors. In the study, we attempted to explore the involvement of GABA B receptors in gabapentin-induced inhibition of the spinal reflexes in spinalized rats. Stimulation of the dorsal root at L5 elicited the segmental mono-(MSR) and polysynaptic reflex (PSR) in the ipsilateral ventral root. The microinjection of gabapentin (1.5 and 5 nmol) into the ventral horn reduced both MSR and PSR, whereas the injection into the dorsal horn only inhibited the PSR, indicating that systemic gabapentin inhibits the MSR at the ventral horn and it inhibits the PSR at both the ventral and dorsal horns. The GABA B -receptor antagonist CGP35348 (0.5 nmol) injected into the ventral horn antagonized the inhibition of the spinal reflexes by the GABA B -receptor agonist baclofen (i.v.) but not by gabapentin (i.v.). Thus, GABA B receptors do not appear to contribute to the gabapentin-induced inhibition of the spinal reflex.

show abstract

Section: Discussionsupporting

confidence: 77%

Section: Introductioncontrasting

confidence: 49%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

GABAB Receptors Do Not Mediate the Inhibitory Actions of Gabapentin on the Spinal Reflex in Rats

et al. 2004

Self Cite

View full text Add to dashboard Cite

show abstract

“…Both gabapentin and pregabalin are structural analogs of GABA, but their mechanisms of action do not include binding to GABA receptors, or affecting GABA uptake or degradation. 13,14 Instead, the pharmacologic action of the agents involve modulating specific voltage-gated calcium channels by binding to its a 2 d-1…”

Section: Anticonvulsantsmentioning

confidence: 99%

Adjuvant Agents in Cancer Pain

McGeeney¹

2008

The Clinical Journal of Pain

View full text Add to dashboard Cite

Cancer-related neuropathic pain derives from peripheral or central lesions of the nervous system and is often associated with the hallmark symptoms of allodynia (pain from a stimulus that does not normally evoke pain) and hyperalgesia (an exaggerated pain response to a normally painful stimulus). Pain is prevalent in patients with cancer and considerably undermines their quality of life, thereby making the development of a comprehensive pain management approach essential. Coanalgesics have been well integrated into cancer pain management strategies and are often used as first-line options for treatment of certain disease processes such as neuropathic pain. These medicines, including antidepressant and anticonvulsant agents, are recommended by evidence-based guidelines, whereas others, such as lidocaine patch 5%, are supported by randomized, controlled, clinical trial data. In addition to understanding which agents are recommended for neuropathic pain, it is useful to know which agents are of limited utility or are to be avoided when prescribing treatment for neuropathic pain. Notwithstanding the need for head-to-head studies before firm statements on comparative efficacy can be made, it is worth considering the numbers needed to treat statistic for the treatment of neuropathic pain with coanalgesics. Potentially harmful treatments are considered, as well as the numbers needed to treat, mechanisms of action, and clinical trial data for agents that can be beneficial for the management of cancer-associated neuropathic pain.

show abstract

Risk Factors Associated with Dizziness and Somnolence in Hospitalized Patients Receiving Pregabalin

Watanabe¹,

Mita²,

Nakamura³

et al. 2014

Jpn. J. Pharm. Health Care Sci.

View full text Add to dashboard Cite

Endogenous GABA Does Not Mediate the Inhibitory Effects of Gabapentin on Spinal Reflexes in Rats

Cited by 3 publications

References 30 publications

GABAB Receptors Do Not Mediate the Inhibitory Actions of Gabapentin on the Spinal Reflex in Rats

GABAB Receptors Do Not Mediate the Inhibitory Actions of Gabapentin on the Spinal Reflex in Rats

Adjuvant Agents in Cancer Pain

Risk Factors Associated with Dizziness and Somnolence in Hospitalized Patients Receiving Pregabalin

Contact Info

Product

Resources

About