Endogenous G-CSF and CD34+ cell mobilization after acute myocardial infarction

Leone, Antonio Maria; Rutella, Sergio; Bonanno, Giuseppina; Contemi, Anna Maria; Ritis, Daniela Giovanna De; Giannico, Maria Benedetta; Rebuzzi, Antonio Giuseppe; Leone, Giuseppe; Crea, Filippo

doi:10.1016/j.ijcard.2005.06.043

Cited by 116 publications

(80 citation statements)

References 14 publications

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“…Kollet et al (22) demonstrated that osteoclast activation following stress and hemorrhage also mobilized progenitor cells into peripheral blood. When comparing patients suffering from acute myocardial infarction to those with stable angina, there is also a differential release of progenitor cells into peripheral blood, 8.6 cells/ μl vs. 3.4 cells/μl (23). Current data supports the finding that the severity of the injury plays a key role in the egress and mobilization of progenitor cells from the BM.…”

Section: Discussionsupporting

confidence: 72%

Beta Blockade Protection of Bone Marrow Following Trauma: The Role of G-CSF

Baranski

Offin

Elhassan

et al. 2011

Journal of Surgical Research

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Background-Following severe trauma there is a profound elevation of catecholamines that is associated with a persistent anemic state. We have previously shown that beta blockade (BB) prevents erythroid growth suppression and decreases hematopoietic progenitor cell (HPC) mobilization following injury. Under normal conditions, granulocyte colony stimulating factor (G-CSF) triggers the activation of matrix metalloprotease-9 (MMP-9), leading to the egress of progenitor cells from the bone marrow (BM). When sustained, this depletion of BM cellularity may contribute to BM failure. This study seeks to determine if G-CSF plays a role in the BB protection of BM following trauma.

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Section: Discussionsupporting

confidence: 72%

Beta Blockade Protection of Bone Marrow Following Trauma: The Role of G-CSF

Baranski

Offin

Elhassan

et al. 2011

Journal of Surgical Research

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“…14,25) Similar to G-CSF, transcription of SDF-1α mRNA is transiently upregulated early after an MI or under hypoxic conditions. 21,26,27) However, our study showed that the change in SDF-1α levels was in contrast to the change in G-CSF levels in a setting of AMI. Immediately after a totally occluded IRA was reperfused, SDF-1α levels decreased relative to the controls and baseline.…”

Section: )contrasting

confidence: 63%

“…Collectively, these data underline the pivotal role of the interplay between the systemic mobilizing effect of G-CSF and the local contribution to engraftment by SDF-1α. 21) VEGF and SCF: In the current study, there were no significant differences in changes of VEGF and SCF levels between the groups. Previously, we showed that tissue VEGF expression peaked approximately 24 hours after ischemic stress.…”

Section: )contrasting

confidence: 52%

“…Previous reports showed that blood G-CSF levels increased after an AMI. 21,22) The G-CSF levels in peripheral blood were significantly correlated with circulating CD34 + angiogenic stem cell amounts. 21) Furthermore, G-CSF not only accelerates stem-cell mobilization but also has roles in protecting cells from injury and facilitating re-endothelialization in injured vessels.…”

Section: Discussionmentioning

confidence: 97%

“…As suggested by the lack of a correlation between CD34 + cell and SDF-1α levels, SDF-1α seems to be a prevalent local mediator for engraftment of stem/progenitor cells rather than a systemic one. 21) Other systemic effectors, such as G-CSF, are needed to mobilize stem/progenitor cells towards the ischemic myocardium. Collectively, these data underline the pivotal role of the interplay between the systemic mobilizing effect of G-CSF and the local contribution to engraftment by SDF-1α.…”

Section: )mentioning

confidence: 99%

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Late Reperfusion of A Totally Occluded Infarct-Related Artery Increases Granulocyte-Colony Stimulation Factor and Reduces Stroma-Derived Factor-1.ALPHA. Blood Levels in Patients With Ongoing Ischemia After Acute Myocardial Infarction

et al. 2009

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SummaryAfter acute myocardial infarction (AMI), reopening of a totally occluded infarct-related artery (IRA) at a subacute stage is still controversial in symptom-free patients. However, in patients with persistent ischemic symptoms and inadequate collaterals to the infarct area, recanalization is thought to provide beneficial effects. In addition to augmenting myocardial perfusion, we hypothesized that the benefit of recanalization involves the manipulation of circulating stem cell-mobilizing cytokines. This study included 30 patients with a totally occluded IRA and ongoing ischemic symptoms (the study group) and 30 patients with a partially occluded IRA (the control group). All patients underwent successful angioplasty and/or stenting. Before and immediately after the coronary intervention, blood granulocyte-colony-stimulating factor (G-CSF), stem-cell factor (SCF), vascular endothelial growth factor (VEGF), and stroma-derived factor-1 (SDF-1α) were measured. After recanalization, G-CSF levels significantly increased in the study group compared to the control group (P = 0.03). SDF-1α levels in the study group decreased relative to the controls (P = 0.02). However, no significant changes in VEGF or SCF levels between the two groups were found. In the multivariate analysis, reopening of a totally occluded IRA was independently and significantly associated with changes in G-CSF and SDF-1α levels after recanalization. In conclusion, our data suggest that the benefits of late reperfusion of a totally occluded IRA in patients with ongoing myocardial ischemia may involve mechanisms associated with stem cell-mobilizing and plaque-stabilizing cytokines. This study provides the rationale to investigate serial changes in cytokines and the numbers of circulating progenitors after reperfusion in the future. (Int Heart J 2009; 50: 433-444)

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WKYMVm-Induced Activation of Formyl Peptide Receptor 2 Stimulates Ischemic Neovasculogenesis by Promoting Homing of Endothelial Colony-Forming Cells

et al. 2014

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Endothelial colony-forming cells (ECFCs) are recruited to the sites of ischemic injury in order to contribute to neovascularization and repair of injured tissues. However, therapeutic potential of ECFCs is limited due to low homing and engraftment efficiency of transplanted ECFCs. The Gprotein-coupled formyl peptide receptor (FPR) 2 has been implicated in regulation of inflammation and angiogenesis, while the role of FPR2 in homing and engraftment of ECFCs and neovascularization in ischemic tissues has not been fully defined. This study was undertaken to investigate the effects of WKYMVm, a selective FPR2 agonist isolated by screening synthetic peptide libraries, on homing ability of ECFCs and vascular regeneration of ischemic tissues. WKYMVm stimulated chemotactic migration, angiogenesis, and proliferation ability of human ECFCs in vitro. Small interfering RNA-mediated silencing of FPR2, but not FPR3, abrogated WKYMVm-induced migration and angiogenesis of ECFCs. Intramuscular injection of WKYMVm resulted in attenuation of severe hind limb ischemia and promoted neovascularization in ischemic limb. ECFCs transplanted via tail vein into nude mice were incorporated into capillary vessels in the ischemic hind limb, resulting in augmented neovascularization and improved ischemic limb salvage. Intramuscular injection of WKYMVm promoted homing of exogenously administered ECFCs to the ischemic limb and ECFCmediated vascular regeneration. Silencing of FPR2 expression in ECFCs resulted in abrogation of WKYMVm-induced in vivo homing of exogenously transplanted ECFCs to the ischemic limb, neovascularization, and ischemic limb salvage. These results suggest that WKYMVm promotes repair of ischemic tissues by stimulating homing of ECFCs and neovascularization via a FPR2-dependent mechanism. STEM CELLS 2014;32:779-790

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Endogenous G-CSF and CD34+ cell mobilization after acute myocardial infarction

Cited by 116 publications

References 14 publications

Beta Blockade Protection of Bone Marrow Following Trauma: The Role of G-CSF

Beta Blockade Protection of Bone Marrow Following Trauma: The Role of G-CSF

Late Reperfusion of A Totally Occluded Infarct-Related Artery Increases Granulocyte-Colony Stimulation Factor and Reduces Stroma-Derived Factor-1.ALPHA. Blood Levels in Patients With Ongoing Ischemia After Acute Myocardial Infarction

WKYMVm-Induced Activation of Formyl Peptide Receptor 2 Stimulates Ischemic Neovasculogenesis by Promoting Homing of Endothelial Colony-Forming Cells

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