Endogenous Formation of Carbon Monoxide in Newborn Infants: II Rh Haemolytic Disease of the Newborn

Fällström, S. P.; Bjure, J.

doi:10.1111/j.1651-2227.1967.tb15394.x

Cited by 16 publications

(20 citation statements)

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“…Consistent with this was our finding that the two most highly associated variables were HbCO and plasma bilirubin. This observation was supported by the results of our multiple regression analyses and by the work of previous investigators (8,10).…”

Section: Discussionsupporting

confidence: 81%

“…fetal HbCO levels were directly correlated with the severity of fetal anemia. In a study of 26 neonates with immune hemolytic disease, Fallstrom and Bjure (8) also observed an inverse correlation of HbCO and Hb levels during the first 12 h of life. In two other studies, increased CO excretion in expired breath of infants with immune hemolytic disease was demonstrated (9,26).…”

Section: Discussionmentioning

confidence: 98%

“…Similarly, neonates with immune hemolytic disease also demonstrated elevated HbCO levels during the first week of life (8,9,26). However, ours is the first study to report HbCO data in undisturbed mid-to lategestation anemic and nonanemic human fetuses.…”

Section: Discussionmentioning

confidence: 99%

“…Previous investigations have demonstrated that HbCO levels in umbilical cord blood at delivery are increased in fetuses with Rh or ABO hemolytic disease (8,10). Similarly, neonates with immune hemolytic disease also demonstrated elevated HbCO levels during the first week of life (8,9,26).…”

Section: Discussionmentioning

confidence: 99%

“…Elevated concentrations of HbCO have been reported at delivery in cord blood of human fetuses and in postnatal blood of newborn infants with immune hemolytic disease (8)(9)(10). Thus far, studies have focused on term fetuses delivered after variable periods of labor.…”

mentioning

confidence: 99%

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Direct Relationship of Fetal Carboxyhemoglobin with Hemolysis in Alloimmunized Pregnancies

et al. 1994

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ABSTRACT. Because carbon monoxide (CO) is a byproduct of heme degradation and because placental diffusing capacity of CO is limited, we hypothesized that the concentration of CO transported in fetal blood as carboxyhemoglobin (HbCO) would correlate with the severity of fetal hemolytic disease. Fetal blood was obtained by cordocentesis and HbCO was measured by gas chromatography. The two primary study groups included control fetuses (n anemic fetuses who were Coombs negative, three of whom had no evidence of hemolysis, indicated normal HbCO and normal plasma bilirubin levels. A fourth fetus with anemia had viral sepsis and elevated HbCO and plasma bilirubin levels. We conclude that elevated HbCO levels detected in fetuses of nonsmoking mothers with erythrocyte alloimmunization are likely the result of accelerated hemolysis.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%