“…The popularity of the transcriptional bursting model is evident by the large number of papers that fit the entire RNA and protein distributions to the two‐state model without considering other sources of variability (Skupsky et al , ; Suter et al , ; Molina et al , ; Dey et al , ). In other cases, cell state was considered using dual reporters (Sigal et al , ; Strebinger et al , ), assuming timescale separation (Dar et al , ), or conditioning on forward scatter (Sherman et al , ). However, without multiplexed expression measurements it is difficult to determine whether conditioning on cell state was done to completion.…”