volume 89, issue 10, P1566-1574 2011
DOI: 10.1002/jnr.22702
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Shin Kato, Mineyoshi Aoyama, Hiroki Kakita, Hideki Hida, Ineko Kato, Tetsuya Ito, Tatenobu Goto, Mohamed H. Hussein, Kazunobu Sawamoto, Hajime Togari, Kiyofumi Asai

Abstract: The hypoxia-responsive cytokine erythropoietin (EPO) provides neuroprotective effects in the damaged brain during ischemic events and neurodegenerative diseases. The purpose of the present study is to evaluate the EPO/EPO receptor (EPOR) endogenous system between astrocyte and oligodendrocyte precursor cell (OPC) under hypoxia. We report here elevated EPO mRNA levels and protein release in cultured astrocytes following hypoxic stimulation by quantitative RT-PCR and ELISA. Furthermore, the EPOR gene expressions…

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